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MRPsych- Clinical psychopharmacology > Modes of action > Flashcards

Modes of action Flashcards

1
Q

Mirtazapine

A 
Antidepressant- 
Noradrenaline and serotonin specific antidepressant (NaSSa) 
5HT2 antagonist, 5HT3 antagonist, 
H1 antagonist, 
alpha 1 and 2 antagonist, 
moderate muscarinic antagonist
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2
Q

Venlafaxine

A

Antidepressant-

Serotonin and noradrenaline reuptake inhibitor (SNRI)

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3
Q

Duloxetine

A

Antidepressant-

Serotonin and noradrenaline reuptake inhibitor (SNRI)

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4
Q

Roboxetine

A

Antidepressant-

Noradrenaline reuptake inhibitor (NaRI)

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5
Q

St John’s wort

A

Antidepressant-
Weak MAOI
Weak SNRI
(also considered to be a weak SSRI)

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6
Q

Trazodone

A

Antidepressant-

Serotonin antagonist and reuptake inhibitor (SARI)

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7
Q

Moclobemide

A

RIMA/MAOI Antidepressant-

Reversible inhibitor of monoamine oxidase type A

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8
Q

Agomelatine

A 
Atypical Antidepressant-
Melatonergic agonist (MT1 and MT2 receptors) and 5-HT2C antagonist
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9
Q

Bupropion (Zyban)

A

Antidepressant-

Norepinephrine and Dopamine reuptake inhibitor (NDRI) and nicotinic acetylcholine receptor antagonist

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10
Q

Donepezil

A

Antidementia-

Reversible anticholinesterase inhibitor

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11
Q

Rivastigmine

A

Antidementia-

Reversible anticholinesterase inhibitor and butyrylcholinesterase inhibitor

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12
Q

Galantamine

A

Antidementia-

Reversible acetylcholinesterase inhibitor and binds allosterically to nicotinic acetylcholinesterase inhibitor

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13
Q

Tacrine

A

Antidementia-

Reversible acetylcholinesterase inhibitor

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14
Q

Memantine

A

Antidementia-

Non-competitive NMDA antagonist

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15
Q

Valproate

A

Mood stabiliser-

GABA agonist and NMDA antagonist

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16
Q

Gabapentin

A

Mood stabiliser-
Mode of action unclear, known to bind to voltage activated calcium channels, unclear if this is how it exerts therapeutic effect

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17
Q

Topiramate

A

Mood stabiliser-

GABA agonist, NMDA antagonist and Na channel stabiliser

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18
Q

Carbamazepine

A

Mood stabiliser-

Stabilises Na channels

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19
Q

Phenytoin

A

Mood stabiliser-

stabilises Na channels

20
Q

Lamotrigine

A

Mood stabiliser-

NMDA antagonist and stabilises Na channels

21
Q

Pregabalin

A

Mood stabiliser-

Potent ligand for alpha-2-delta subunit of voltage-gated calcium channels

22
Q

Diazepam

A

Benzodiazepine/ GABA-A agonist

23
Q

Lorazepam

A

Benzodiazepine/ GABA-A agonist

24
Q

Temazepam

A

Benzodiazepine/ GABA-A agonist

25
Q

Clonazepam

A

Benzodiazepine/ GABA-A agonist

26
Q

Midazolam

A

Benzodiazepine/ GABA-A agonist

27
Q

Zolpidem

A

Z drug/ GABA-A agonist

28
Q

Zopiclone

A

Z drug/ GABA-A agonist

29
Q

Buspirone

A

anxiolytic / 5HT1A partial agonist

30
Q

Ketamine

A

NMDA antagonist

31
Q

Phencyclidine

A

Drug of abuse (PCP) NMDA antagonist

32
Q

Lofexedine

A

Aids with opiate withdrawal / Alpha 2 agonist

33
Q

Clonidine

A

ADHD tx, Aids with opiate withdrawal / Alpha 2 agonist

34
Q

Buprenorphine

A

Aids with opiate withdrawal / Partial agonist of mu opioid receptor

35
Q

Naloxone

A

Tx for opiate OD / Pure opioid antagonist

36
Q

Atomoxetine

A

ADHD tx / Noradrenaline reuptake inhibitor

37
Q

Varenicline

A

Nicotine withdrawal aid / Nicotonic receptor partial agonist

38
Q

Disulfiram

A

Induces acute sensitivity to alcohol for tx of alcoholism
Binds to acetaldehyde dehydrogenase causing acetaldehyde to accumulate. This leads to flushing, severe headache, respiratory distress, nausea and vomiting

39
Q

Acamprosate

A

treatment for alcoholism / metabotropic glutamate receptor antagonist and GABA-A agonist

40
Q

Selegiline

A

Treatment for parkinsonianism and as an adjunct to co-beneldopa or co-careldopa to reduce end of dose deterioration / selective, irreversible inhibition of monoamine oxidase type B (also inhibits MAO-A at higher doses

41
Q

Sildenafil

A

Erectile dysfunction / Inhibits cGMP-specific phosphodiesterase type 5 (PDE5)

42
Q

Amisulpride

A

2/D3 selective antagonist (low affinity selective antagonist of ‘D2 like’ receptors (D2=D3>D4) it has little affinity for D1 like’ receptors (D1 and D5) or non dopaminergic receptors (serotonin, histamine, adrenergic, and cholinergic)

43
Q

Olanzapine

A

Dopamine and 5HT2 antagonism

44
Q

Aripiprazole

A

Partial agonist at 5HT1A and D2, and 5HT2A antagonist

45
Q

Clozapine

A

High affinity for D4, (to a lesser extent D1, D2, D3, D5) also 5 HT 1A partial agonist and 5HT2 antagonist

MRPsych- Clinical psychopharmacology (3 decks)

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