Module 1 Flashcards

1
Q

Osteoarthritis (OA), also known as

A

degenerative joint disease (DJD) or “wear and tear” arthritis, is the most common articular disease in adults older than age 45. It is the most widespread form of arthritis and is a significant cause of functional impairment, chronic pain, and disability in the older population.

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2
Q

OA risk factors

A

In addition to age, risk factors include genetics, female sex, joint injury, past trauma, advancing age, obesity, and mechanical stress

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3
Q

Principal sites for OA are

A

the distal interphalangeal (DIP) joints, the proximal interphalangeal (PIP) joints, and the carpometacarpal (CMC) joint of the thumb in the hand; the first metatarsophalangeal or great toe joint; and the hips, knees, and cervical and lumbar spine.

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4
Q

OA symptoms

A

Osteoarthritis affects the distal interphalangeal joints (Heberden’s nodes) and PIP joints (Bouchard’s nodes) and presents with swelling, stiffness, pain, and deformity.

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5
Q

RA symptoms

A

usually presents as bilateral pain, swelling, and stiffness of the metacarpophalangeal and PIP joints with characteristic deformities and spares the DIP joints. Generally, other systemic complaints will occur, and joints other than just those in the hand will be affected as well

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6
Q

OA subjective presentation

A

slowly developing, localized gradual pain in affected joints
early morning stiffness which subsides after 30 mins “gel phenemenon”

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7
Q

OA objective presentation

A

minimal or no swelling of affected joints
tenderness on direct palpation
reduced passive/active ROM
crepitus
often asymmetrical

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8
Q

OA DI

A

Primarily clinical dx
Can use plain XR to r/o other condition- may reveal bony cysts, sclerosis, asymmetrical joint space narrowing

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9
Q

OA tx focus

A

Control pain
Manage symptoms
Maximize functional independence/mobility
minimize disability

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10
Q

core tx for all OA pts

A

land based exercise
strength training
weight management
water based exercise
self management
education

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11
Q

non pharm OA tx

A

Education
weight loss
physical therapy, OT
heat, ice, US
accupuncture, supplements

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12
Q

OA hand pharm tx

A

*Topical capsaicin

*Topical NSAIDs

*Oral NSAIDs

*Tramadol

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13
Q

knee OA pharm tx

A

*Acetaminophen

*Oral NSAIDs

*Topical NSAIDs

*Tramadol

*Intra-articular corticosteroid injections

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14
Q

hip OA pharm tx

A

*Obesity management (moderate evidence)

*Nonnarcotic management (strong evidence): oral NSAIDs improve short-term pain function

*Physical therapy (strong evidence)

*Intra-articular corticosteroid injections (strong evidence)

*Mental health disorder (moderate evidence): management of depression, anxiety, and psychosis impact pain relief, function, and ADL

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15
Q

tramadol contra

A

etoh, hypnotics, other narcotics, SSRI

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16
Q

steroid injection OA

A

knee, hip if under fluro
lidocaine typically mixed with steroid
rest joint x1 day, limit activity for 2-3 days
no more than 3-4/yr
can accelerate joint deterioration, increase risk of avascular necrosis

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17
Q

OA most affective sx intervention

A

total joint replacement

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18
Q

Osteoporosis is a

A

generalized skeletal disorder characterized by normal bone mineralization but low bone mass (bone mineral density [BMD]) and disruption of the bony architecture, both of which result in an increased risk of fractures

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19
Q

osteoporosis clinical manifestations

A

vertebral, hip fractures

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20
Q

osteomalacia

A

, which denotes a decrease in actual bone mineralization

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21
Q

of women older than 50 in USA who will experience hip, spine, wrist fracture

A

4 in 10

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22
Q

Women have a two to four times greater lifetime risk of sustaining an osteoporotic fracture than men do because

A

of the loss of BMD following the cessation of ovarian estrogen production at menopause

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23
Q

most rapid bone loss women age

A

decade after menopause

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24
Q

risk for repeat fracture if already had one

A

5x

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25
dietary risk factor for osteoporosis
lack of adequate calcium intake throughout life
26
osteoporosis risk factor
female smoking low calcium intake sedentary lifestyle long term steroid use testosterone deficiency
27
only "early" symptom of osteoporosis
gradual development of upper/mid thoracic back pain associated with activity or long periods of standing/sitting
28
vertebral compression fracture presentation
sudden, severe onset of pain, point tenderness, "dowagers hump"
29
osteoporosis risk assessment tools
SCORE, FRAX
30
osteoporosis screening
DEXA- utilize Z scores and T scores BAP (bone alkaline phosphatase) most commonly available serum indicator of osteoblastic activity
31
Medicare-approved indications for BMD testing include
(1) estrogen-deficient women at risk for osteoporosis, (2) patients with vertebral abnormalities, (3) patients receiving or needing to be on long-term glucocorticoids, (4) patients with primary parathyroidism, and (5) patients being monitored for response or efficacy of an approved osteoporosis drug therapy.
32
osteoporosis management goals
prevent fractures stabilize/improve bone mass maximize physical functioning relieve symptoms
33
osteoporosis lifestyle management
smoking cessation moderation of etoh weight bearing exercise adequate calcium, vitamin D eliminate fall hazards in home
34
calcium, vitamin D intake daily for osteoporosis
calcium 1200mg daily-- however best source is from dietary sources 800 iu vitamin d
35
type of calcium suggested for osteoporosis
calcium carbonate less expensive, more easily absorbed with meals
36
first line pharm tx osteoporosis
bisphosphonates
37
bisphosphonate limitations
pharm therapy for 5 years with no bone density monitoring
38
bisphosphonate side effects
irritate upper GI mucosa must be taken whole in the morning with glass of water before other food/drink, remain upright x30 minutes
39
repeat BMD testing for tx response every
2 years
40
obesity associated comorbidities
ted public health problems. It is associated with multiple comorbidities, including an increased risk of cancer, cardiovascular disease, disability, diabetes mellitus, gallbladder disease, high blood pressure, osteoarthritis, sleep apnea, and cerebrovascular accident (stroke).
41
two types of obesity
central (apple shaped) lower body (pear shaped)
42
Patients with central obesity have excessive body fat in the abdomen and flank areas and are at a greater risk for
type 2 diabetes mellitus, coronary artery disease (CAD), stroke, and early death,
43
% of adults overweight or obese
70.2%
44
overweight BMI
25-29.9
45
obesity class 1 bmi
30-34.9
46
obesity class 2 bmi
35-39.9
47
obesity class 3 bmi
>40
48
extragenetic causes of obesity
cultural/environmental factors suboptimal nutrition/physical inactivity disrupted sleep cycle med side effect stress neuro dysfunction viral infection gut microbiome alterations
49
cancer risk increase obesity males
colon, rectal, prostate
50
cancer risk increase obesity females
uterine, gallbladder, biliary tract, breast, ovarian
51
most common genetic syndromes with obesity
Prader-Willi syndrome Bardet-Biedel syndrome
52
obesity subjective symptoms
fatigue, decreased energy, weakness, joint pain, SOB, daytime sleepiness, depression
53
bmi not accurate in
muscular individuals
54
methods to measure for central obesity
waist circumference measurment calculate waist-hip ratio
55
obesity labs
TSH, glucose, Hga1c, FLP, liver function, alk phos, bili, vitamin D, CBC
56
Metabolic syndrome is a constellation of risk factors including
hypertension, hyperlipidemia, insulin resistance, and overweight/obesity that significantly increases an individual’s risk of cardiovascular disease and diabetes mellitus
57
tx obesity
combo of diet, exercise, behavioral intervention
58
weight loss goal obesity
10% decrease in weight over 6 months
59
weight loss calorie deficit
500-750 calorie/day deficit
60
obesity pharm management
orlistat lorcaserin phentermine contrave saxenda
61
obesity surgery
BMI over 40 or BMI over 35 with comorbid conditions must fail conventional weight loss therapies
62
most common obesity surgery
roux-en Y gastric bypass
63
gout
metabolic disease produces inflammatory arthritis
64
risk factor gout
male use of diuretics
65
hyperuricemia definition
uric acid above 7 in men 6 in women
66
Most individuals (90%) with gout have
inappropriate underexcretion of uric acid.
67
mechanisms that trigger acute attack of gout
trauma surgery
68
gout stages
asymptomatic acute phase intercritical chronic tophaceous
69
acute phase
inflammatory phase extremely painful joints, red/swollen elevated wbc, temp, serum uric acid
70
intercritical phase
interval b/tw phases asymptomatic
71
chronic tophaceous
results from recurrent attacks restrict movement of affected joints
72
gout subjective
pain tenderness erythema swelling of affected joints mono articular, joint most frequently affected first joint of big toe excruciating pain that awakens pt at night not relieved with rest
73
gout objective
affected area warm or hot to touch pain on palpation limited rom podagra most affecte
74
gout testing
serum uric acid definitive test= microscopic observation of urate crystals in aspirated joint fluid
75
gout tx initial
NSAIDs- indomethacin or naproxen, steroids, rest,
76
colchicine
effective to terminate acute attack of gout if given within 36 hours of onset of symptoms 1-1.2mg given at first sign of attack, followed by 0.5-0.6 every 1 until pain relieved
77
meds to lower uric acid levels
probenecid allopurinol febuxostat not to be started during or within 1 month of acute attack
78
dietary modifications gout
avoid purine rich foods (meats, seafood, yeast, beer, beans) adequate fluid intake moderate etoh
79
physical activity during acute gout attack
restricted, bedrest x24 hours
80
linea nigra
, a brownish black pigmented vertical stripe along the midline skin,
81
The uterus increases in weight from approximately
70 g at conception to almost 1,100 g at delivery, when it accommodates from 5 to 20 L of fluid
82
anteverted
(forward-leaning)
83
retroverted
backward leaning
84
retroflexed
backward bent
85
chadwick sign
vagina and cervix blue color
86
leukorrhea of pregnancy
normal vaginal secretions become thick, white and more profuse
87
hegar sign
palpable softening of cervical isthmus
88
breast changes during pregnancy
moderately enlarged more nodular nipples larger, more erectile darker areola, more pronounced montgomery glands
89
EDD
add 7 days to LMP, then add 9 months
90
Gravidity refers to
the number of times that a woman has been pregnant,
91
parity is the
number of times that she has given birth to a fetus to a viable age (≥24 gestational weeks), regardless of whether the child was born alive or was stillborn.
92
prenatal visits
initial visit q 4 weeks until 28 weeks q2 weeks until 36 weeks q1 week until delivery
93
weight loss due to nausea/vomiting that exceeds
5% is considered excessive, aka hyperemesis gravidarum
94
Gestational hypertension
is systolic blood pressure (SBP) >140 mm Hg or diastolic blood pressure (DBP) >90 mm Hg first documented after 20 weeks, without proteinuria or other evidence of preeclampsia, that resolves by 12 weeks postpartum.
95
mammary souffle
increased blood flow through breast vasculature cause strongest in 2nd or 3rd intercostal space
96
fetal movement
can be felt externally @24 weeks by patient at 18-24 weeks
97
if fundal height 4 cm larger than expected consider
multiple gestation large fetus extra amniotic fluid uterine leiomyoma
98
if fundal height 4 cm smaller than expected consider
low level amniotic fluid missed abortion IUGR fetal anomaly
99
Adnexal tenderness or masses early in gestation
require ultrasound evaluation to rule out ectopic pregnancy. Acute pelvic inflammatory disease is rare in pregnancy, especially after the first trimester, because the adnexa are sealed by the gravid uterus and mucus plug.
100
unilateral severe edema with calf tenderness
warrants prompt eval for DVT
101
Leopold maneuvers
used to determine fetal position in maternal abdomen in 2nd trimester, greatest accuracy after 36 weeks
102
pregnant pt to avoid these foods
Unpasteurized milk and foods made with unpasteurized milk Raw and undercooked seafood, eggs, and meat Refrigerated paté, meat spreads, and smoked salmon Hot dogs, luncheon meats, and cold cuts unless served steaming hot
103
weight gain in pregnancy
determined by BMI prior to pregnancy
104
acog physical activity recommendations
<30 min moderate exercise most days of week unless contraindications
105
leading cause of preventable mental disability in USA
fetal alcohol syndrome
106
vaccines safe during pregnancy
pneuococcal meningococcal hep B inactivated flu
107
vaccines not safe during pregnancy
mmr live attenuated flu polio zoster varicella
108
prenatal lab screening
ABO and Rh (D) type RPR bacteruria hep b HIV iron deficiency gestational diabetes screening
109
diabetes screening test in pregnancy
50g oral glucose tolerance test glucose checked 1 hour after glucose load, threshold of 130-140. If positive, then must do 100g 3 hour diagnostic OGTT screen 24-28 weeks
110
prenatal vitamins
folate, b12 iron