Module 1

Question 1

Basic studies of chemistry and physics shifted from the greco roman to arabian alchemist. Paracelsus glorified

Answer 1

Middle ages

Question 2

Morphine extracted from poppy by serturner

Answer 2

1805

Question 3

Organon der rationellen helikunde published by samuel hahneman on his unproven principle similia similibus curantur cures homeopathy

Answer 3

1810

Question 4

Isolation of emetine from ipecacuanha by pierre pelletier

Answer 4

1816

Question 5

Purification of caffeine quinine and colchicine

Answer 5

1820

Question 6

Mass production of pharmaceutical natural product pelletier factory processed 150,000kg of cinchona bark annually to produce 3600kg quinine sulfate

Answer 6

1826

Question 7

Adolph kolbe synthesis of acetic acid

Answer 7

1845

Question 8

First alkaloid synthesis coniine

Answer 8

1886

Question 9

Ehrlich described sidechain theory germicidal capability of a molecule depend on its structure

Answer 9

1897

Question 10

The first mass produced synthetic drug aspirin Bayer

Answer 10

1898

Question 11

Single most important break through in psychiatric treatment

Answer 11

Chlorpromazine

Question 12

Discovery of antidepressant effect

Answer 12

on iproniazid

Question 13

First dibenzazepine

Answer 13

Imipramine

Question 14

First commercially successful SSRI 1 billion

Answer 14

Fluoxetine

Question 15

First pure hormone to be isolated

Answer 15

Epinephrine

Question 16

Henry Dale discovered oxytocin

Answer 16

1904

Question 17

Frederick banting and charles best discovered insulin

Answer 17

1921

Question 18

Edward kendall isolated thyroxine from the thyroid gland

Answer 18

1914

Question 19

First genetically engineered drug approved by US FDA

Answer 19

Humulin by eli lily

Question 20

For type 1 diabetes inhaled insulin

Answer 20

Symlin 2005

Question 21

Russel marker was able to convert diosgenin to progesterone

Answer 21

1930

Question 22

Carl djerassi synthesized norethindrone norminest first orally contraceptive

Answer 22

1950

Question 23

1956 john rock

Answer 23

Progesterone plus norethindrone

Question 24

Mifepristone abortion pill

Answer 24

1980

Question 25

Mifepristone plus misoprostol

Answer 25

1994

Question 26

Morning after pill

Answer 26

Aka plan B Emergency contraceptive Levonorgestrel

Question 27

Dentist who administered nitrous oxide during tooth extraction

Answer 27

Horace wella

Question 28

Used ether as an anesthetic agent

Answer 28

Crawford long

Question 29

Gave the first successful public demonstration of surgical anesthesia 1846

Answer 29

William morton

Question 30

Used as an anesthetic agent at St bartholomews hospital

Answer 30

Chloroform

Question 31

Induce sleep

Answer 31

Laudanum

Question 32

1864 adolph von beyer synthesized

Answer 32

5,5- diethylbarbituric acid Barbital

Question 33

Bayer pharmacy company introduced

Answer 33

Phenobarbital Luminal

Question 34

Modification of the barbituric acid molecule led to the development of

Answer 34

Hydantoins

Question 35

diphenylhydantoin

Answer 35

Phenytoin (Dilantin®)

Question 36

1860 – Albert Niemann isolated

Answer 36

cocaine (Erythroxylon coca)

Question 37

Found that cocaine numbed the tongue § First to use cocaine for topical anesthesia in ophthalmological surgery

Answer 37

Carl Koller (“Coca Koller”)

Question 38

determined the structure of cocaine and atropine

Answer 38

Richard Willstater

Question 39

Structural analog of cocaine

Answer 39

Benzocaine, procaine, tetracaine and lidocaine

Question 40

discovered Digitalis purpurea was beneficial to those suffering from abnormal fluid buildup

Answer 40

1775 – William Withering

Question 41

isolated digitoxin

Answer 41

1841 – E. Humolle and T. Quevenne

Question 42

isolated digoxin

Answer 42

1929 – Sydney Smith

Question 43

Discovered the first anticholesterol drug – Compactin (Mevastin) – Penicillium citrinum

Answer 43

1973 Akira Endo

Question 44

discovered a substance nearly identical to Endo’s and named Lovastatin (Mevacor®)

Answer 44

1987 – Merck

Question 45

First FDA - approved statin

Answer 45

Atorvastatin (Lipitor®)

Question 46

Sulfur mustard (WW1) and nitrogen mustard (WW1) -

Answer 46

leukemia therapy

Question 47

George Hitchings and Gertrude Elion developed

Answer 47

6-mercaptopurine – The first effective leukemia drug

Question 48

Inorganic; the gold standard against which new medicines are compared – Carboplatin – 2nd gen

Answer 48

1893 - Cisplatin

Question 49

discovered Paclitaxel (Taxol)

Answer 49

1963 – Moeroe E. Wall and Masukh C. Wani

Question 50

A scientific discipline at the intersection of chemistry and pharmacy involves designing, synthesizing, and developing pharmaceutical drugs.

Answer 50

Organic Pharmaceutical Chemistry

Question 51

involves the identification, synthesis, and development of new chemical entities suitable for therapeutic use.

Answer 51

Medicinal chemistry

Question 52

focused on quality aspects of medicines and aims to assure fitness for medicinal products.

Answer 52

Pharmaceutical chemistry

Question 53

(QSAR)

Answer 53

Quantitative Structure-Activity Relationships

Question 54

Is a strategy of essential importance for chemistry and pharmacy, based on the idea that when we change the structure of a molecule then the activity or property of the substance will be modified.

Answer 54

Quantitative Structure-Activity Relationships (QSAR)