Module 1 Flashcards

1
Q

_____________ communicated physically, using electrochemical
signals between the brain and other organs, such as muscle group, or signals
from one organ to another, as in a ___________

A

Nervous System
Reflex arc

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2
Q

____________ communicated via chemical blood-borne messengers, for instance between the ____________and the ______________.

A

Endocrine System
Pituitary Gland and Adrenal Cortex

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3
Q

its communication via ___________ is very rapid

A

nervous system

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4
Q

its communication via ____________ is slower

A

endocrine system

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5
Q

It is customary and convenient to categorize _____________, _____________, ______________,
_______________, _____________, and _____________ functions
into physiological systems, anatomic and functional components of thesesystems overlap to lesser or greater degrees.

A

Cardiovascular
Respiratory
Reproductive
Gastrointestinal
Nervous
Endocrine

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6
Q

it is significantly dependent on hormones from the endocrine system for normal function

A

nervous system

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7
Q

considered a component of
the endocrine system, ishighly integrated
with the nervous system

A

adrenal medulla

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8
Q

What is Endocrinology?

A

it is the study of communication
within a living organism by means of hormones.

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9
Q

What is hormone?

A

are the chemical messengers of the
endocrine system

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10
Q

The discipline of endocrinology includes the?

A

✓ study of hormones
✓ the anatomy and physiology of the cells,tissues, and organs that produce these
hormones
✓ the way that hormones are transported
and action target cells
✓ clinical abnormalities of hormonal deficiencies and overproduction.

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11
Q

In the classical sense, a hormone was described as a?

A

chemical messenger secreted from a ductless gland, emptied directly into the circulation, and transported by the blood

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12
Q

Components of the endocrine system that
communicate by routes other than blood vessels
are characterized as;

A

✓ Paracrine
✓ Autocrine
✓ Neurocrine
✓ Solinocrine

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13
Q

hormones
are secreted locally into the extracellular
space only to self-regulate thevery cells that
released them

A

Autocrine communication

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14
Q

involves secretion of hormones from a cell directly into the
surrounding extracellular space; the hormone then interacts with adjacent or nea-rby cells without being transported by blood

A

Paracrine communication

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15
Q

delivers very high concentrations of the hormone
to its target site.

A

Paracrine communication

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16
Q

involving
secretion of peptides or other neurotransmitter molecules by neurons,is a specialized form of paracrine function in which
the chemical messenger is transferred to a
target cell via asynapse or neuromuscular
junction

A

Neurocrine communication

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17
Q

Several hormones are secreted directly into the lumen of the gastrointestinal, respiratory and
reproductive tracts. This type of communication is called?

A

Solinocrine

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18
Q

example of solinocrine

A

gastrin, somatostatin, vasoactiveintestinal peptide, calcitonin, secretin, and serotonin

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19
Q

Functions of Hormones

A

✓ A single hormone can affect a single function
✓ single hormones having
multiple actions
✓ multiple hormones having single actions
✓ multiple hormones producing multiple
actions

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20
Q

Example of A single hormone can affect a single function

A

✓ erythropoietin on hemoglobin synthesis by erythrocytes, but this one-on-one action is very rare.

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21
Q

example of multiple hormones having single actions

A

✓ regulation
of lactation by prolactin, placental lactogens ,corticosteroids, thyroxine, sex steroids, and oxytocin

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22
Q

Example of multiple hormones producing multiple
actions

A

reproductive steroids, oxytocin,
and corticosteroids on pregnancy, fetal development, and parturition.

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23
Q

it depends on the effects of
hormones on gametogenesis as well as development of sexual characteristics and elicitation of behaviors that culminate in the fertilization of
an oocyte by a spermatozoon and the production
of offspring

A

Reproduction

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24
Q

Many hormones play important functions
for the maintenance of pregnancy, such as?

A

✓ embryo and fetus
✓ development of the reproductive tract for pregnancy
✓ and initiation of parturition

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25
are also important in timing the cessation of growth
hormones
26
Example of why hormone are important in timing the cessation of growth?
hormone-mediated closure of the epiphyses of long bones after maturity is necessary for proper adult body conformation
27
Maintenance of an animal’s internal environment requires metabolic energy generated from nutrients processed by enzymes regulated by hormones. Such as.
✓ Production ✓ storage ✓ utilization of energy-require complex endocrine-regulated ingestive, digestive, anabolic, catabolic, and excretory processes.
28
protein hormones include?
Prolactin and growth hormone
29
Glycoprotein hormones include?
✓ thyrotropin or thyroid stimulating hormone (TSH) ✓ luteinizing hormone (LH) ✓ follicle-stimulating hormone (FSH)
30
Peptide hormones include?
✓ insulin ✓ insulin-like growth factor-1 (IGF-1) ✓ adrenocorticotropic hormone (ACTH)
31
hormones that are derivatives of amino acids?
✓ Triiodothyronine (T3) ✓ catecholamines such as epinephrine and norepinephrine
32
The large category of lipidic hormones includes the subcategories of steroids;
✓ progesterone ✓ estrogens ✓ androgens ✓ glucocorticoids ✓ mineralocorticoids
33
Example of eicosanoids
✓ prostaglandin ✓ thromboxanes ✓ leukotrienes
34
chemical nature of hormone
present in the blood and other extracellular fluids in low concentrations
35
The range of hormone concentration from in extracellular fluids;
10^-11 to 10^-9 M
36
The range of concentrations of nonhormonal amino acids, peptides, and lipids:
10^-5 to 10^-3 M
37
synthesized by Leydig cells of the testis, diffusesonly a short distance to Sertoli cells and to the adluminal compartment ofthe seminiferous epithelium to promote spermatogenesis
testosterone
38
the hormonally active form of testosterone in the male, is produced by androgen-sensitive target cells such as those of the prostate
Dihydrotestosterone
39
is converted to T3 within cells of the pituitary glandto play a major role in the regulation of TSH secretion
Thyroxine (T4)
40
one anatomic feature that efficiently dir- ects hormones to their target tissues is the so- called?
portal circulation
41
consists of blood flow from capillaries in one organ to a vein and then to capillaries in another organ.
Portal circulation
42
Adrenocorticotropin (ACTH) is a 39-amino acid peptide derived from a much larger precursor (235 amino acids) called?
proopiomelanocortin (POMC)
43
Other peptides with hormonal activity derived from POMC include :
(i) melanocyte-stimulating hormone (ii) beta-endorphin (iii)beta-lipotropin.
44
is synthesized as part of a larger precursor by the chief cells of the parathyroid gland.
parathyroid hormone
45
other prohormones
(i) proinsulin (ii) proglucagon (iii) progastrin (iv) procalcitonin.
46
a prohormone, is converted to the hormone triiodothyronine (T3) in the liver,kidney, brain, and pituitary gland.
Thyroxine (T4)
47
produced from androgen precursors, primarily androstenedione in females and testosterone in males, by enzymes present in peripheral nonendocrine tissues
Estrogens
48
synthesize the hormone at faster rates, efficiently process prohormones, and havemechanisms for releasing the hormone in a controlled manner
endocrine glands
49
Water-soluble hormones
Proteins and peptides
50
do not require additional carrier proteins for transport
water-soluble hormones
51
the ___________ hormones such as ____________ and ___________ require carrier proteins
insoluble iodothyronines and steroids
52
found within the sequence of a larger gastrointestinal form of glucagon called enteroglucagon, glicentin, or glucagon-like immune reactivity.
Pancreatic glucagon
53
require carrier proteins.
insoluble proteins Ex. iodothyronines and steroids
54
means regulation of hormonal secretion from an endocrine gland by an effect of the circulating hormone that the gland itself produces.
feedback control
55
negatively controls PTH secretion, glucose negatively controls glucagon and positively controls insulin secretion, and the volume of extracellular fluid negatively controls aldosterone production by feedback mechanism
ionized calcium
56
A few hormones are produced without feedback regulation. Those produced by the placenta, such as;
equine chorionic gonadotropin progesterone estrogens
57
All hormone receptors are proteins and have two functional domains;
✓ recognition domain ✓ coupling domain
58
that regulates post-binding biochemical events
coupling domain
59
General principles of hormone action
✓ Intracellular Action of Steroid Hormones ✓ Intracellular Action of Iodothyronines ✓ Intracellular Actions of Protein and Polyp- eptide Hormones
60
Second messenger for hormonesthat bind to cell surface receptor include
cyclic AMP (cAMP)
61
Concentrations of cyclic AMP increaseor decrease in response to many hormones, including;
ACTH, LH, FSH, calcitonin, and PTH
62
a process mediated by a family of stimulatory and inhibitory regulatory proteins.
adenylate cyclase
63
Changes in ionized calcium within the cell regulate a protein
Calmodulin
64
The four criteria for assay validity are;
(i) specificity (ii) accuracy (iii) precision (iv) sensitivity.
65
defined as freedom from interference by substances other than the one intended to be measured
specificity
66
the extent to which a set of measurements of a substance agrees with the exact amount ofthe substance that is present
accuracy
67
the extent to which a given set of measurements of the same sample agrees with the mean
precision
68
defined as the smallest amount of unlabeled hormone that can be distinguished from havingno hormone in the sample.
sensitivity
69
is often the result of an autoimmune process whereby the thyroid gland isinvaded by immune cells and the hormone-secreting cells are destroyed
Primary Hypothyroidism
70
can be due to insufficient secretion of TSH, but it should be distinguishedfrom “hypothyroxinemia”, which can be produced by concurrent disease, e.g., hyperadren- ocorticism,malnutrition, and certain drugs.
Secondary Hypothyroidism
71
in dogs, can occur as a result of a developmental defect whereby hormone-secretingcells of the anterior pituitary gland fail to differentiate completely, leading to multiple deficiencies
panhypopituitarism
72
owing to diminished FSH and LH secretion
hypogonadism
73
caused by reduced ACTH secretion
secondary hypoadrenocorticism
74
young puppies will express the condition as _____________ because there is a lack ofgrowth hormone secretion
pituitary dwarfism
75
caused by excessive production of cortisol by the adrenal cortex
Hyperadrenocorticism
76
results from excessive secretion of ACTH by the pituitary gland, causing morphologic and functional hyperplasia ofthe adrenal cortex.
Secondary hyperadrenocorticism (Cushing’s disease)
77
is due to excessive autonomous secretion of parathyroid hormone
Primary hyperparathyroidism
78
is one of the most common endocrinopathies in cats and is related to the excessive secretion of iodothyronines by proliferative lesions of the follicular cells of the thyroid gland
hyperthyroidism
79
caused by neoplasia of the pancreatic beta cells, leading to hypoglycemia.
Hyperinsulinemia
80
is an unfavorable responseto therapy caused by the therapeutic effort itself
iatrogenic disease
81
The disease shows the same manifestation as _____________, which is the spontaneous disease
Cushing's syndrome
82
which can be produced by concurrent disease, e.g., hyperadrenocorticism,malnutrition, and certain drugs.
hypothyroxinemia