Module 10: OCD-related disorders Flashcards

1. Module background 1-9, 2. Lecture 10-64 3. Jassi & Krebs 65-69 (69 cards)

1
Q

Nowadays OCD belongs to what category in the DSM-5? where did it belong before?

A

now: obsessive-compulsive and related disorders

before: anxiety disorders

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2
Q

what are obsessive compulsive and related disorders characterized by?

A
  • irresistible urge to perform distressing and time consuming compulsive behaviors
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3
Q

Hoarding disorder

A

persistent difficulty of disposing of belongings due to a strong need to save objects + suffering associated with disposing of them

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4
Q

Body dysmorphic disorder

A

Preoccupation with one or more subjectively perceived defects or imperfections in one’s appearance that are not perceived by others or are considered by them to be insignificant.

This is associated with repetitive body-oriented behavior (e.g., grooming, seeking reassurance) or psychological activity (e.g., comparing one’s own appearance with that of others).

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5
Q

Trichotillomania

A

Repeated pulling of the hair despite attempts to stop it.

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6
Q

Skin picking disorder

A

Repeated plucking of the skin causing skin lesions, despite attempts to stop it.

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7
Q

4 other types of o-c disorders

A
  • O-C or related disorder due to substance/medication
  • O-C or related disorder due to a somatic condition
  • Otherwise specified O-C or related disorder
  • The unspecified O-C or related disorder
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8
Q

What suggests that there is a common genetic and neuropsychological processes underlie these different disorders

A

There is a lot of comorbidity between different compulsive disorders within individuals and families

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9
Q

Overlap in the neuropsychological basis

A

cognitive impairments in motor inhibition and cognitive flexibility underlie not only OCD but also OC-related disorders albeit to different degrees

e.g., impaired response inhibition is demonstrated in trichotillomania but not cognitive flexibility

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10
Q

O-C and related disorders in DSM-5 and ICD-11. In ICD these 3 disorders are included on top of the ones already in DSM-5

A
  1. Hypochondriasis
  2. Olfactory reference syndrome
  3. Tourette syndrome
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11
Q

Body dysmorphic disorder: core symptom

A

Belief that you are ugly -> when others only see small differences
- it is about beauty and beauty matters

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12
Q

BDD symptoms: there is a focus on (4)

A
  • facial features (80%)
  • But can be any body part –> in many patients its multiple 5-7 different body parts
  • Suicidal ideation 80%, attempts 24-28%
    (adolescents 44%)
  • Shame & self-disgust even higher in OCD
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13
Q

compulsive behavior in the context of BDD

A

Engagement in all kinds of compulsive behaviors to get rid of blemishes or insecurities
E.g., checking social media, checking behavior in general, excessive surgery, exercise etc.

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14
Q

DSM-5 criteria of BDD (5)

A
  • Preoccupation with one or more perceived defects or flaws in physical appearance that are not observable or appear slight to others
  • Repetitive behaviors (e.g., mirror checking) or mental acts (e.g., comparing his or her appearance concerns
  • The preoccupation causes clinically significant distress or impairment in social, occupational or other areas of functioning
  • The appearance preoccupation is not better explained by concerns with body fat or weight in an individual whose symptoms meet criteria for an eating disorder
  • specifier: muscle dysmorphia & insight
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15
Q

Difference to OCD

A
  • At least 80% of patients have poor or absent insight
  • they believe the way they experience symptoms is the way it is

other differences listed later in another card

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16
Q

Similarity to OCD: there is a lot of comorbidity in BDD (6)

A
  • Personality disorders: 57% (aovidant & dependent)
  • misuse of drugs, alcohol etc. (up to 50%)
  • up to 80% have depression
  • social anxiety disorder up to 70%
  • up to 17% OCD (perfectionistic)
  • ED’s up to 32% (AN up to 9%)

in clinical practice we see:
lots of rejection sensitivity and anxiety (SAD)
perfectionism (OCD)

(- gender dysphoria? & - ASS?, these are not elaborated on)

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17
Q

BDD vs OCD

BDD features (5)

A
  • little or no insight
  • single (e.g., due to lots of issues with sexuality and sexual intimacy)
  • sexual emotional past traumatic events
  • depression-suicidal ideation-SUD-social phobia
  • avoidant personality disorder
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18
Q

BDD vs OCD

Common features (5)

A
  • genetic overlap (82% shared genetic vulnerability)
  • physical past traumatic events
  • sex ratio
  • trait of perfectionism
  • body image disturbance
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19
Q

BDD vs OCD

OCD features (3)

A
  • better insight
  • OCD symmetry concerns
  • obsessive-compulsive personality disorder
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20
Q

BDD vs AN (similarities) (4)

A
  • body image disturbance
  • perfectionism and deficits in body size estimation
  • higher intensities or negative emotions, greater utilization of worrying
  • abnormalities in visuospatial processing and reward processing
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21
Q

BDD vs AN (differences) (5)

A
  • Body weight/shape vs any other body part / more body parts (face)
  • BDD: more hopelessness, psychosocial impairment & familial burden
  • BDD: higher delusionality, poorer QoL
  • AN: lower self-esteem and increased levels of MDD
  • increased insula-orbitofrontal cortex connectivity in AN, and increased occipital cortex connectivity in BDD
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22
Q

Bigorexia nervosa / muscle dysmorphia

A

closer to AN than BDD
* obsessions about the smallness and weakness of own body
* excessive physical exercise and changes in diet +/- anabolic steroid abuse

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23
Q

Prevalence of BDD

A

Quite similar to OCD
* General pop. 1-2%
* Adult comm. Samples: more in women
* Psychiatric setting: equal sex ratio

  • McGrath: meta-analysis
    pooled prevalence: 11,3%
    cosmetic/dermatology settings: 20%
    mental health settings: 7,4%
    students and ballet dancers: 6,7%
  • McLean (2022): significant BI dissatisfactions: 13% of Australian population
  • BDD is under-recognized in mental health care and it takes 5-10 years to get a diagnosis after onset of symptoms
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24
Q

Screening questionnaires for BDD, where to use and why?

A

Many patients do not go to a psychiatrist, of course, their symptoms are somatic and therefore they think that they need to go to a dermatologist, cosmetologist, a surgeon etc.

We therefore need good questionnaires to screen in different outpatients clinics.

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25
BDD screening in Utrecht
* New patients at the outpatient clinic of dermatology, plastic surgery and maxillofacial surgery * BDDQ-DV * Severity of defect scored by surgeon, dermatologist, or cosmetic doctor --This was important to find because if there was a severe defect, then patient did not meet criteria for BDD
26
Salari (2022) meta-analysis prevalence of BDD
combined all studies on prevalence and replication studies of the Utrecht study Results: One in three patients visiting clinics of rhinoplasty has BDD - quite serious because this is a high prevalence
27
Tros (2023): prevalence of BDD in adolescents
* BDD DSM-5 criteria * 105 adolescents with acne (13-24 years old) * 12% BDD
28
# pathophysiology of BDD Visual information processing: Feusner (2024)
found that: * Ppl with BDD have a much more detailed visual information processing compared to controls * They focus on details instead of being able to look at the bigger picture these correlated with brain activation * Overactivity in the VVS vs in the DVS * These correlate to enhanced detail processing and to severity of BDD symptoms
29
# Pathophysiology in BDD Neurotransmitters and brain circuits: Vulink (2016)
DA in BDD: * higher dopaminergic signal in the brain compared to controls * similar to OCD also seen in the serotonin system
30
# Pathophysiology in BDD Genes (3)
* family members with BDD 8% * People who have OCD are more likely to have close family members who also have BDD, compared to people without OCD * Twin studies: 64% shared genetic vulnerability between BDD and OCD
31
# Pathophysiology in BDD Psychological factors (3)
Biases in selective attention * Focused on specific details (disorder relevant stimuli and self referent and aesthetic details like symmetry) * Others try to avoid details (e.g., looking in the mirror) Distorted cognition * Perfectionistic thinking and maladaptive beliefs (e.g., about importance of attractiveness), tendency to form conclusions without sufficient information and misinterpret ambiguous social scenarios as negative and threatening Memory deficits * inaccurate coding and recall of face and body stmiuli
32
# Pathophysiology in BDD Personality factors (5)
* Perfectionistic tendencies * Neuroticism * Behavioral/social inhibition * Unassertiveness * Rejection sensitivity
33
Cultural, familial and identity factors (6)
* Higher prevalence of BDD symptoms: exposure to unrealistic beauty standards * High levels of family dysfunction/overprotection in families of individuals with obsessive compulsive and related disorders * Family accommodation can reinfroce the disorder, particularly in pediatric BDD * Gender: Women: focus on more areas of the body, increased distress, less illness insight, more sfaety behaviors, earlier age of onset Men: worse overall functioning * Greater rates of BDD symptomatology in queer individuals and in racial/ethnic minority individals * Suicidality is also increased - Esp.committing suicide In males with BDD
34
The role of trauma: early childhood adversity (4)
* physical abuse/neglect: 14-55% * Sexual trauma /abuse: 22-35% * Emotional neglect /abuse: 28-68% * Appearance and competence teasing
35
the role of social media and BDD
* "upward comparison" & BDD (judgement bias) -- People focus on those that "look better" Only a few studies: They show increased/worsened symptoms with social media use
36
Why is the most often used treatment intervention for BDD, cosmetic treatment?
with poor insight, patients do not feel they need psychiatric treatment, they want cosmetic treatments as they believe this is the only solution
37
# treatment A) cosmetic treatment (4)
* 48-76% of patients with BDD get cosmetic treatment before psychological treatment * 26-66% different cosmetic procedures * Little satisfaction in the long term * More procedures -> worse prognosis
38
# treatment are cosmetic surgeries actually useful?
Studies show mixed results in terms of improvement after cosmetic treatments -> no definitive answer BUT a lot of studies showing improvement have methodological limitations (only questionnaire) + the FU is really low (few weeks)
39
# treatment what did Brown (2024) find regarding cosmetic procedures and their usefulness + what is a useful progression that followed?
Only 8% developed BDD after a cosmetic procedure and all others improved on BDD * Now every professional working in cosmetic surgery required to screen for BDD * This is useful for filtering out those patients that will not benefit from your treatment
40
# treatment B) Medication, SSRIs
similar to OCD, SSRIs do help in BDD * 2 RCTs: 50-60% response (have a significant decrease in their symptoms) * Placebo controlled discontinuation: relapse 40% vs 18% (much higher in the placebo group) * Open label studies with fluvoxamin Good results
41
# treatment B) Medication, Tricyclic antidepressants that bind to serotonin
Clomipramine vs desipramine * 65% response vs 5% response
42
# treatment B) Medication, antipsychotic addition
* 1 RCT: pimozide addition: No response * Should be repeated, to see for which patients it worked Combining SSRIs with antipyshocitcs then it worked a little bit
43
# treatment B) Medication, psilocybine (tgt with psychotherapy)
* 12 weeks FU: 58% of responders * Could add to possibility of treatment
44
# treatment CBT: factors that contribute to development (3)
1. genetics/personality/psychological factors 2. environment: social media, cultural and familiar factors 3. Trauma and stressful events
45
# treatment 3) CBT: core feature of the CBT model
Main feature is the selective attention for appearance features: --> all kidns of negative thoughts and beliefs about their appearance --> leads to anxiety, shame, etc --> BDD rituals, avoidance Similar to OCD rituals
46
# treatment 3) CBT model, which added elements distinguish the model from CBT model for OCD (2)
* personality dimension * trauma therapy
47
# treatment 3) CBT, motivating patients to start: theory A, theory B
Hard to start, but once treatment is started patients report satisfaction Coming in contact with others with BDD can be very helpful as an experience 1. Theory A, Theory B Only when they are convinced to go for another theory , will they be able to start: - Theory A: the way they experience their symptoms now (e.g., cosmetic procedures and other rituals diminish other symptoms) - Theory B: tell patient that this way of thinking doesnt work --> go for a different theory, OUR theroy Inclusion of cognitive interventions to break rituals
48
# treatment 3) CBT, motivating patients to start: GOAL setting (3)
- Agree with patient on goals to achieve - They are unable to make small goals (e.g., overshoot "i want to not have any compulsions anymore) - Compulsions are easier to target but obsessions do not change --> patients become better in dealing with
49
# treatment 3) CBT motivating patients to start: inquire about pro's of the status quo
This is done in order for them to gain insight into their rituals and whether they are functional
50
# treatment 3) CBT, cognitive therapy and the reasoning process
in cognitive therapy the reasoning process of patients is what you try to uncover e.g., reasoning process 1. my nose looks ugly 2. other people see it 3. when others look at my nose they will have a negative judgement 4. the assumption that if others don't like one thing they will disapprove me completely
51
# treatment 3) CBT: thought challenging
1) What you see is that most of their self worth is built in their appearance - The point is to see if there are any other qualities in the patient that tcontribute to self worth - Usually always yes (e.g., being a family member etc.) 2) Challenge core beliefs: multidimensional evaluation - Go to core belief (most times its a belief of feeling completely worthless) - ask to imagine a person they know that is worthless and valuable - then ask patient to write down what kind of characteristics make someone a valuable person or a worthless person - Make dimensions of these different characteristics - Now they have to score themselves again on these dimensions They see that if they have different dimensions within worthlessness They see that they score much higher on specific dimensions than others (??)
52
# treatment 3) CBT: thought records
Automatic vs helpful thoughts - How can they change to helpful thoughts - Which situations trigger which thoughts
53
cognitive distortions
1. **all or nothing thinking** 2. catastrophizing 3. **mind reading** 4. mental filter 5. overgeneralization 6. emotional reasoning 7. should statements 8. ignoring the good 9. minimizing 10. blaming 11. personalization 12. **jumping to conclusions** 13. **measuring with double standards**
54
dysfunctional assumptions (4), how can you identify and find out about them?
* automatic thoughts my nose/hair/skin look ugly others are also convinved that this is the case * basal assumptions/core cognition I am worthless * conditional assumptions If i do not look perfect, i will be rejected by others When i am not attractive, my life wont mean anything * instrumental assumptions I have to look into the mirror because I need to know how I look Nobody is allowed to disapprove my appearanc because I cant tolerate it --> you can identify these using a functional analysis You address these differently in therapy
55
CBT: exposure to avoidance (4)
* Social situations * Public transport * (eye) contact with others * Showing yourself without cap, glasses, make-up
56
CBT: Response prevention focused on decreasing BDD rituals (5)
* Not allowed to do compulsive rituals * Mirror gazing, skin picking * Make-up or hair rituals * Confirmation behavior * Checking/comparing/social media
57
Effect of hyperfocusing on one specific area
Doing this increases BDD symptoms + other psychological symptoms --> in CBT essential to explain this to patients as well: Showing patients that hyperfocusing on a specific feature is detrimental
58
CBT: mirror retraining
Teaching to avoid mirrors FIRSTLY 1. Explain that a mirror is not your friend 2. Explain that don't look into it that often 3. At least one arms reach away from it Mirror retraining: - Positive mirroring or objetive describing - Gradual exposure: start mirroring a body part distant fom the BDD focus - Gradually increase this area of tolerance Can also use this technique w/ pics and movies - Desrcibing a picture in general
59
CBT + Medication vs CBT alone
1st part of treatment: offer medication as symptoms decrease more when medication used tgt with CBT - Compared to just CBT - Esp in the beginning this was used to ease the anxiety that patients experienced rgarding starting CBT but also anxiety that pre-existed
60
BDD and psychotherapy: what do studies show in general
* CBT: Up to 84% of patients responding, still like in OCD 15-25% no remission --> we look for other ways * Trauma treatment & BDD: - Imaginary rescripting: Positive results * Supportive PT (SPT): also improved holistic and emotionally accurate processing * Acceptance and compassion focused therapy
61
The unmet treatment need in BDD (4)
* Schulte (2020): 60,1% with BDD: no lifetime treatment, only 22% received medication or CBT * Only 13% of patients with CBT had received all components * Marques (2011): medication (SSRI or clomipramine): 40% * Individual-level treatment barriers: shame and stigma
62
neuromodulation, rTMS study
* 6 patients with BDD + severe depression * Same protocol as in OCD and depression (same target area) No sham control condition results: * 4 of 6 patients did improve and were really happy with results --> rtms study * 5 of 6 really improved in depressive symptoms
63
Summary | rTMS
rTMS in combination with medication: * 47% decrease in BDD symptoms * 62% decrease of depressive symptoms peak-effect after 10 sessions 2 non-responders: low insight, increased suicidality, no FU, not continuing with rTMS for long could lead to high relapse rates -> maybe DBS is better
64
DBS
* Positive results also with DBS * 1 patient treated, something to look for in the future
65
Name meental health conditions that are frequently comorbid with BDD (4)
1. major depression 2. social anxiety disorder 3. **obsessive-compulsive disorder (OCD),** 4. **eating disorders.**
66
Why is a thorough risk assessment important when evaluating an individual for BDD?
Risk assessment is important because BDD is associated with high rates of suicidality. Assessing for suicidal ideation and behavior is crucial for safety.
67
Explain the concept of Exposure and Response Prevention (ERP) in the context of BDD treatment.
exposing individuals to situations that trigger their appearance concerns or repetitive behaviors and preventing them from engaging in their usual avoidance or ritualistic responses. This helps to habituate them to the distress and experience distress habituation.
68
What is the purpose of mirror retraining in CBT for BDD?
help patients view themselves more objectively and globally, focusing on their whole body rather than obsessing over perceived flaws. It aims to reduce self-critical judgment.
69
similarities (3) /differences (2) between BDD and SUD
similarities: * compulsive checking behavior and compulsive drug use * biases in selective attention * memory deficits differences: * CBT for BDD focuses on body image and SSRIs * CBT for SUDs focuses on MI and medication assisted treatment