module 12 other cell wall-acting agents Flashcards Preview

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Flashcards in module 12 other cell wall-acting agents Deck (12)
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1
Q

monobactam Rx

A

aztreonam

2
Q

aztreonam MOA

A

inhibit cell wall synthesis

- binds to PBP-3 in gram - bacteria

3
Q

aztreonam spectrum of activity

A

gram - including: pseudomonas aeruginosa

4
Q

aztreonam uses

A

good substitute for pt with penicillin allergy or inc. risk of aminoglycoside toxicity

5
Q

glycopeptides MOA

A

inhibit cell wall synthesis

  • binds to D-alanyl-D-alanine precursor in gram + bacteria
  • > no peptidoglycan cross linking
6
Q

vancomycin spectrum of activity

A

gram + only

  • MRSA
  • enterococcus
  • coagulase - neg. staph
  • oral: c. diff
7
Q

vancomycin precaution

A

dose adjust with renal insufficiency

8
Q

vancomycin AE

A

red mans syndrome: related to infusion

rare: nephrotoxicity, ototoxicity

9
Q

vancomycin monitoring

A

drug level: trough

10
Q

glycopeptide Rx

A

vancomycin
televancin
dalbavancin
oritavancin

11
Q

televancin, dalbavancin, oritavancin spectrum of activity

A

Gram + only

- staph, strep, enterococcus

12
Q

televancin, dalbavancin, oritavancin education

A

less monitoring than vanco

simplified dosing

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