Module 1.2.1

Question 1

therapeutic strategies for inflammatory pain

Answer 1

NSAIDs
glucocorticoids
DMARDs

Question 2

MOA of NSAIDs

Answer 2

inhibition of prostaglandin synthesis, inhibit COX 1 and 2 to some degree. some NSAID’s have additional MOAs

Question 3

celecoxib MOA

Answer 3

reversibly inhibits COX 2 enzyme
10-20x more selective for cox2 than cox1

Question 4

celecoxib MOA

Answer 4

reversibly inhibits COX 2 enzyme
10-20x more selective for cox2 than cox1

Question 5

celebrex brand and dosing

Answer 5

celecoxib 100mg bid or 200 mg daily

Question 6

moloxicam brand and dosing

Answer 6

mobic
15mg dialy
cap: 5 mg up 10 mg daily
tab/odt/susp 7.5 mg daily up to 15 mg daily

Question 7

piroxicam brand and dosing

Answer 7

feldene 10-20mg daily

Question 8

ibuprofen brand and dosing

Answer 8

motrin, advil
200-400 po q4-6 hrs or 200-800mg 3-4 times daily max dose 3200/day

Question 9

naproxen brand and dosing

Answer 9

Aleve, Naprosyn
220mg pd bid (max (660)
500 mg po bid (max 1000 mg/day)