module 2 Flashcards
(51 cards)
7 aspects of bradford hill criteria
temporality
strength of association,
consistency of association,
biological gradient,
biological plausibility of association, specificity of association,
reversibility
what is temporality
first cause then disease - establish a causal relationship
what is strength of association
stronger an association - more likely to be causal in absence of known bias
reversibility
under controlled conditions the change in exposure = change in outcome
biological gradient
incremental change in disease rates in conjunction with corresponding changes in exposure
biological plausibility of association
does the association make sense biologically
consistency with association
replicate findings by different investigators at different times in different places with different methods so multiple studies show similar results
specificity of association
cause leads to single effect and effect has single cause
what is a causal pie for
showing multicausality
what is sufficient cause
min set of conditions for a disease to occur - one of these missing = disease does not occur
component cause
each slice is a factor that contributes to disease causation but doesnt cause it on its own but through interactions with other components
necessary cause
must be present for disease
blocking/removal of any component cause
result in prevention in some cases
nearly every causal mechanism has
one environmental cause
problems with causal pie model
assumes that all causes are deterministic so A causes B - fails to capture dose-response as a continuum
probabilistic concept of causation
cause increases chance that its effect will occur - does not include the necessary, component and sufficient causes
sufficient cause raises probability to
1
necessary cause raises probability
from 0
each component cause contributes towards probability from
0 to 1
counterfactual
a makes difference to b
deterministic
a causes b
probabilistic
a increased chances of b occurring
social gradient
step wise increase - people in less deprived areas do better than people in more deprived
level 1 of dalhgren and whitehead
individual non mod and lifestyle