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Phlebotomy Lecture Finals > Module 3 > Flashcards

Module 3 Flashcards

1
Q

Factor I

A

Fibrinogen

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2
Q

Factor lll

A

Tissue Factor

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3
Q

Blood clot that forms in a large vein in the leg

A

Deep venous thrombosis

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4
Q

Pathological, widespread clotting and fibrinolysis at the same time, in which coagulation factors are consumed to such an extent that bleeding occurs

A

Disseminated intravascular coagulation (DIC)

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5
Q

Genetic disorder characterized by bleeding due to increased coagulation time

A

Hemophilia

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6
Q

Hemophilia A is also known as

A

Factor Vlll deficiency

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7
Q

Hemophilia B is also called as

A

Factor IX

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8
Q

Abnormal decrease in platelets

A

Thrombocytopenia

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9
Q

What are the tests for hemostatic process?

A

D-dimer
Factor Assays
Fibrin degradation products(FDP)
Platelet function assay (PFA)
Prothrombin time (PT)
Partial thromboplastin time(PTT / APTT)

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10
Q

What is the first coagulation disorder to be recognized during second century?

A

Hemophilia

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11
Q

A chronic, malignant disorder, common in males characterized by lymph node enlargement

A

Hodgkin disease

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12
Q

an infection of the lymphatic system caused by Epstein-Barr virus

A

Infectious mononucleosis

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13
Q

Infectious mononucleosis is caused by

A

Epstein-barr virus

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14
Q

Inflammation of the lymph vessels

A

Lymphangitis

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15
Q

Inflammation of one or more lymph nodes

A

Lymphadenitis

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16
Q

Disease of the lymph nodes, often associated with node enlargement such as seen in mononucleosis

A

Lymphadenopathy

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17
Q

Sometimes benign but usually malignant

A

Lymphoma

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18
Q

Term for lymphoid tumor

A

Lymphoma

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19
Q

Spleen enlargement

A

Splenomegaly

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20
Q

What are the tests for lymphatic system disorders?

A

Bone marrow biopsy
Complete blood count (CBC)
Lymph node buopsy
Mononucleosis (mono) test

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21
Q

Where is axillary lymph nodes located?

A

Nodes in the armpit

22
Q

The process by which fibrin is dissolved

A

Fibrinolysis

23
Q

What are the two activities of fibrinolysis?

A

Dissolves clots (thrombi) that form within intact vessels

Removes hemostatic clots from tissue as healing occurs

24
Q

What substance converts plasmin?

A

Plasminogen

25
An enzyme that breaks down fibrin into smaller fragments called the degradation products
Plasmin
26
What do fibrin splits?
Products and D-dimer
27
Bleeding is associated with
Increased fibrinolytic activity
28
Thrombosis is associated with
Decrease fibrinolytic activity
29
What does the liver synthesize/s in hemostasis?
Factor V Factor Vlll Prothrombin Fibrinogen
30
Who produce heparin naturally in the body?
Mast cells (tissue basophils) in the liver
31
What happens when liver is diseased?
Bleeding may result
32
Liver produces bile salts for
Absorption of Vitamin K
33
Vitamin K deficiency can result to
Elevated PT and APTT, and potential bleeding
34
Used for treating clotting disorders
Coumarins (coumadin and other warfarin trade names)
35
How does coumarin works?
By inhibiting the proper synthesis of the vitamin-K dependent factors
36
What are the three natural inhibitor?
Antithrombin (AT) Heparin cofactor ll (HCll) Proteins C and S
37
Developed to inactivate thrombin inside a clot and prevent clot propagation with clotting disorders, such as deep venous thrombosis
Drug fondaparinux sodium (Arixtra)
38
It is developed because antithrombin is too large to get into a clot
Findaparinux sodium (Arixtra)
39
They keep the coagulation process in check and limited to local sites by degrading and activated coagulation factors that escape the injury site and remain within the formed clot
Natural inhibitors
40
What is the flow of hemostatic process?
Vasoconstriction Primary Platelet Plug Secondary Platelet (Amplification - Propagation) Fibrinolysis
41
When does thrombin production ends?
With clot formation
42
Factor ll
Thrombin
43
What is the difference between hemostasis and coagulation?
Hemostasis is the overall stoppage of bleeding while coagulation is the process to achieve hemostasis
44
Acute blood loss in the vein
Hemorrhage
45
Responsible for production of platelets
Megakaryocyte
46
What is the lifespan of platelet
About 10 days
47
First line defense for inflammation
Monocyte
48
It release histamine and heparin that enhances inflammatory response
Basophils
49
What is RBC formation?
Erythropoiesis
50
The process of erythropoiesis is regulated by
Erythropoietin

Phlebotomy Lecture Finals (8 decks)

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