Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

HEMA 256 > Module 3: Mechanisms of Normal Hemostasis > Flashcards

Module 3: Mechanisms of Normal Hemostasis Flashcards

1
Q

Factor I common name

A

Fibrinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Factor II common name

A

Prothrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Factor IIa common name

A

Thrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Factor III common name

A

Tissue factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Factor V common name

A

Labile factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Factor VII common name

A

Stable factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Factor VIII common name

A

Antihemophilic factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Factor IX common name

A

Christmas factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Factor X common name

A

Stuart-Prower factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Factor XI common name

A

PTA (plasma thromboplastin antecedent)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Factor XII common name

A

Hageman factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Factor XIII common name

A

Fibrinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Fibrinogen roman numeral

A

I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Prothrombin roman numeral

A

II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Thrombin roman numeral

A

IIa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Tissue factor roman numeral

A

III

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Labile factor roman numeral

A

V

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Stable factor roman numeral

A

VII

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Antihemophilic factor roman numeral

A

VIII

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Christmas factor roman numeral

A

IX

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Stuart-Prower factor roman numeral

A

X

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

PTA (plasma thromboplastin antecedent) roman numeral

A

XI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Hageman factor roman numeral

A

XII

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Fibrinase roman numeral

A

XIII

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

5 major components of hemostasis

A 
Vascular
Platelet
Coagulation system
Fibrinolytic system
Natural anticoagulants and inhibitors
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Vascular endothelial cells are thromboresistant by secreting:

A

Heparin sulphate
Prostacyclin (prostaglandin)
Nitrous oxide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

How does heparin sulphate contribute to thromboresistance?

A

Inhibits coagulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

How does prostacyclin contribute to thromboresistance?

A

Inhibits platelet adhesion and aggregation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

How does nitrous oxide contribute to thromboresistance?

A

Relaxes smooth muscles in subendothelial area and prevents vasoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

2 types of vasoconstriction

A

Muscular

Humoral

31
Q

Tissue thromboplastin acts as a coenzyme with factor VII to activate:

A

Extrinsic coagulation

32
Q

Tissue plasminogen activator (tPA) activates:

A

The fibrinolytic system

33
Q

3 tests for vascular responses:

A

Bleeding time
Closure test
Capillary fragility test

34
Q

Endothelin is:

A

Secreted by endothelial cells

Induces smooth muscle contraction in surrounding subendothelial tissue

35
Q

Damaged vessels or injured cells release/expose:

A 
Tissue thromboplastin (factor III)
Tissue plasminogen activator (tPA)
36
Q

Thrombopoiesis differs from other blood cells by:

A

Megakaryocytes get larger as they mature

No cellular division; endomitosis (repeated nuclear divisions) within developing cells

37
Q

Platelet lifespan in the blood:

A

8-10 days

38
Q

Peripheral zone of platelet

A

Outer coating = glycocalyx (mostly glycoprotein)

Important in adhesion and aggregation

39
Q

Sol-gel zone of platelet

A

Cytoskeleton (contractile proteins - thrombosthenin and actinomysin)
Platelet retraction, shape change (viscous metamorphosis in secondary aggregation)

40
Q

Organelle zone of platelet

A

Canicular system
Dense bodies
Alpha (translucent) granules
Dense tubular system

41
Q

Canicular system

A

Carries granular contents to the surface

42
Q

Dense bodies

A

Rich in serotonin and other vasoactive catecholamines, ADP, ATP, calcium, pyrophosphate

43
Q

Alpha (translucent) granules

A

PF3, fibrinogen, thrombospondin, PF4

44
Q

Dense tubular system

A

Calcium

Important in platelet retraction and prostaglandin synthesis

45
Q

% of platelets in circulation

A

70%

46
Q

% of platelets sequestered in the spleen

A

17%

47
Q

% of platelets in liver, lungs, and bone marrow

A

13%

48
Q

PF1 is:

A

Absorbed coagulation factor V

49
Q

PF2 is:

A

Fibrinogen activating factor

50
Q

PF3 is:

A

Platelet phospholipid

51
Q

PF4 is:

A

Anti-heparin factor

52
Q

2 platelet function groups

A

Hemostatic

Thromboplastic

53
Q

Platelet adhesion requires:

A

Glycoprotein 1b complex (GP1b)

von Willebrand’s factor (VWF) - part of factor VIII complex

54
Q

2 platelet aggregation phases

A

Primary (reversible)

Secondary (irreversible)

55
Q

Primary aggregation requires:

A

ADP
Glycoprotein IIb/IIIa complex
Calcium
Fibrinogen (factor I)

56
Q

The contractile protein involved in platelet retraction is:

A

Thrombosthenin

57
Q

Cheating agents inhibit platelet aggregation by:

A

Removing calcium (essential for secondly aggregation)

58
Q

Heparin inhibits:

A

Thrombin

59
Q

Aspirin inhibits platelet aggregation by:

A

Inhibiting thromboxane A2 synthesis in platelets

60
Q

Factor V is a coenzyme for factor:

A

X

61
Q

Factor VIII is a coenzyme for factor:

A

IX

62
Q

HMWK is a coenzyme for factor:

A

XII

63
Q

Factor III is a coenzyme for factor:

A

VII

64
Q

Factor VIII is made up of which two components

A

Antihemophilic factor

von Willebrand’s factor

65
Q

Contact group:

A

HMWK, PK, XI (PTA), XII (Hageman factor)

His private parts hurt

66
Q

Prothrombin group

A

II, VII, IX, X
Prothrombin, stable, Christmas, Stuart-Prower
Presents save Christmas Santa

67
Q

Fibrinogen group

A

I, V, VIII, XIII
Fibrinogen, labile, antihemophilic, fibrinase
Fancy ladies acquire funds

68
Q

Intrinsic system factors

A

HMWK, PK, XII, XI, IX, VIII

69
Q

Extrinsic system factors

A

VII, III

70
Q

Common pathway factors

A

X, V, II, I, XIII, IV

71
Q

PT measures factors:

A

VII, X, V, II, I
Stable, Stuart-Prower, Labile, prothrombin, fibrinogen
Silly sluts love pillow fights

72
Q

APTT measures factors:

A

HMWK, I, PK, XII, IX, VIII, X, V, II, XI
HMWK, PK, Hageman, Christmas, Antihemophilic, Stuart-Prower, labile, fibrinogen, prothrombin, PTA
Horny prostitutes have coitus and spread legs for precious pennies

73
Q

Prothrombin is activated into thrombin by:

A

Xa, Va, PF3, Ca2+

74
Q

Thrombin’s major functions are

A

Converts fibrinogen into fibrin
Activates factor XIII
Enhances activity of factors V and VIII
Induces platelet aggregation

HEMA 256 (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions