Module 5 Flashcards
(55 cards)
Inflammation “inflammare” means
“to set in fire”
a process in which an excess blood is brought to the irritated area and its constituents are poured out into tissues in an attempt to dilute the irritant, localized its effect, and destroy it completely
Inflammation
Cardinal Sign: due to delivery of warm blood to the area, by hyperemia and increased vascular dilatation
Heat
Cardinal Sign: due to stimulation of nerve endings by cytokines and inflammatory mediators and increased pressure due to stretching and distortion of tissues
Pain
Cardinal Sign: due to hyperemia or dilatation of small blood vessels in tissues
Redness
Cardinal Sign: due to edema/ accumulation of fluid in extravascular space due to increased capillary permeability
Swelling
Cardinal Sign: movement is inhibited especially by pain and severe swelling
Loss of Function
Calor means?
Heat
Dolor means?
Pain
Rubor means?
Redness
Tumor means?
Swelling
Who discovered the first 4 cardinal signs?
Cornelius Celsus
What are the major changes during inflammatory process?
Vascular
Exudative
Proliferative
Major changes during Inflammatory Process associated with hyperemia and increased permeability
Vascular
Major changes during Inflammatory Process escape of fluid, cells or cellular debris from blood vessels and deposition on tissues
Exudative
Major changes during Inflammatory Process associated with fibroplasia and angiogenesis
Proliferative
is the term used to describe any elevation in core body temperature above the accepted normal range for that species.
Hyperthermia
Explain how fever helps the body
- Fever increases the activity of white blood cells and the production of interferons, which help fight infection.
- Fever increases the body’s metabolic rate, which helps produce heat and fight infection.
- Fever causes vasoconstriction, which reduces heat loss.
- Fever can cause shivering, which increases heat production.
These are protein and polysaccharide substances that are released either frombacteria or viruses or from destroyed cells of the body.
Pyrogen
Two group classification of Pyrogens
Endotoxins and Non-endotoxins
Pyrogen Endotoxins are substances found in
Gram-negative bacteria
This group of pyrogens are other microbial substances, including those derived from Gram-positive bacteria or viruses and pyrogens originating from yeasts and fungi.
Non-endotoxin Pyrogens
area group of chemically diverse substances that cause fever and shock in severe cases.
Pyrogens
Type of Inflammation:
caused by predominating cells include neutrophil (with some eosinophil & mobile macrophages)
Acute Inflammation