module 5 Flashcards

1
Q

whats the six process of digestive system in order

A
ingestion
propulsion
mechanical breakdown
chemical digestion
absorption
defection
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2
Q

whats ingestion

A
  • Taking food and water into digestive tract

- Usually occurs via the mouth; involves the lips and tongue.

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3
Q

whats proplusion

A
  • Moving food through digestive tract
  • Starts when swallowing (initiated voluntarily)
  • Peristalsis
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4
Q

whats peristalsis

A

alternate wave of muscle contraction and relaxation (involuntary) around the food. Squeeze food along the pathway. powerful

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5
Q

whats mechanical breakdown

A
  • Physically breaking the food up into smaller fragments so it can be digested involves;
  • Mouth; chewing and mixing food with saliva
  • Stomach’ churning and mixing with gastric juice= liquid mixture
  • Small intestine’ segmentation= mixes food with digestive juices and acids in nutrient absorption. Increases efficiency of absorptions and ability of enzymes to act on food
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6
Q

whats chemical digestion

A
  • enzymes break down complex food molecules into their building blocks (monomers)
  • Occurs in the mouth, stomach and in the small intestine
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7
Q

whats absorption

A
  • Passage of end products (monomers) from the lumen of the digestive tract into te blood or lymph.
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8
Q

whats defection

A
  • Elimination of indigestible substances, in the form of faeces, from the body via the anus.
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9
Q

what the four layers/tunics of the walls of the digestive tracts

A
  1. mucosa
  2. submuscosa
  3. muscularis externa
  4. serosa
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10
Q

whats the mucosa

A

the innermost layer is a moist membrane that lines the lumen from mouth to anus. As the name suggest it secretes mucus, which eases the passage of food and protects the organs from itself being digested by enzymes. This layer also secretes digestive enzymes and hormones as well as absorb nutrients that have been digested.

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11
Q

whats the submucosa

A

external to the mucosa and contains elastic tissue to allow stretch and recoil after temporarily storing a meal.

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12
Q

whats the muscular external

A
  • surrounds the submucosa is composed of smooth muscle cells and responsible for peristalsis and segmentation. It forms a sphincter to ensure food travels in one direction.
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13
Q

whats the serosa

A

outermost layer that supports the digestive organs and anchors them to surrounding structures.

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14
Q

what do the walls of the digestive tract also have

A
  • Blood vessels to absorb the products of digestion
  • Parasympathetic and sympathetic nerves to alter motility of the digestive system
  • Lymphatic vessels from lipid transport
  • Lymphoid tissue for immune function
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15
Q

what does the mouth do

A
  • Modified muscoa: lined by stratified, squamous epithelium (continually replaced due to absorption)
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16
Q

whats the digestive functions of the mouth

A
  • Ingestion: food is voluntarily placed into the oral cavity
  • Mechanical breakdown by mastication (chewing), tongue mixes food with saliva
  • Chemical digestion of carbohydrates initiated by enzymes (amylase) found in saliva
  • Propulsion (peristalsis)- swallowing food
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17
Q

what does the salivary glands do

A
  • Produce saliva which contains mostly water, mucus, electrolytes, digestive enzymes and antimicrobial proteins.
  • Functions of saliva:
  • Mucus moistens and lubricates food
  • Dissolves food chemicals and facilitates tastes
  • Contains enzymes (amylase) that initiates chemical digestion of carbohydrates.
  • Primary controlled by parasympathetic nervous system
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18
Q

whats the pharynx and oesophagus do

A
  • Propulsion (peristalsis) of food to the stomach
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19
Q

whats special about the stomachs wall layers/tunic

A
  • Muscularis externia; circular and longitudinal- mix, churn and propel food
  • Modified contains an additional oblique muscle layer in muscularis externia= pummels the food and rams chime into the small intestine.
  • Modified muscoa: the surface of the mucosa is composed entirely of mucus producing cells (goblet cells). Muscoa indented into gastric pits= gastric glands.
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20
Q

what does gastric pits contain

A
  • Parietal cells; produce hydrochloric acid(HCI), activate pepsin, denature proteins and destroys most bacteria.
  • Chief cells; produce pepsinogen, the inactive form of pepsin
  • Goblet cells; mucus protect musoca from HCI
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21
Q

whats the functions of the stomach

A
  • Mechanical breakdown- mixing food with gastric juice
  • Chemical digestion of proteins initiated (pepsin)
  • Absorption (minor role) of fat soluble chemicals eg alcohol, and aspirin
  • Propulsion (peristalsis) to the small intestine
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22
Q

whast the three subdivisions of the small intestine

A
  • Duodenum: curls around the pancreas, receives bile and pancreatic juice for chemical digestion
  • Jejunum: major site of mechanical and chemical digestion and absorption
  • Ileum: ends at the large intestine
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23
Q

whats the three structural modifications of the small intestine for nutrient absorption

A
  • Circular folds; deep, permanmetn folds of the mucosa and submusoca. Slow the movement of chyme, thus increasing the time for nutrient absoprtion
  • Villi: finger like projections of the musoca. Absorptive epithelial cells= nutrient absorption. Core contains a capillary bed and a wide lymph capillary. Contain goblet cells to produce mucus. Enterocytes produce intestinal juice.
  • Microvilli: very small, densly packed on the surface of individual absorptive epthlieal cells= form the brush border. Plasma memebrane bears enzymes that complete carbohydrate, protein and nucleinx acid digestion (brush brer enzymes)
  • = surface area increases more than 600 times.
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24
Q

whats the functions of the small intestine

A
  • Propulsion: food moves along the tract
  • Mechanical breakdown: segmentation mixes the food with digestive jucies
  • Chemical digestion 4 classes; carbohydrates, proteins, fats and nucleic acids
  • Nutrient absorption: nutrients absorbed into the blood (fats move into the lymph
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25
Q

whats the functions of the large intestine

A
  • Absorption: water and electrolytes, vitamins produced by bacterial flora
  • Propulsion; haustral contractions and mass movements
  • Defaecation; parasympathetic reflex. Triggers by distension of the rectum to eliminate facese fmor the body.
  • Chemical digestion: remain foods are digested by enteric bacteria
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26
Q

what the arlge intestine modified about the tunic

A
  • Modified mucosa= simple epithelium; rich in goblet cells = ease the passage of faeces, protect the intestinal wall from bacterial acids and gases.
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27
Q

whats accessory organs of the digestive system include

A

liver
gall blader
pancreas

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28
Q

whats the function of the liver

A
  • Produce bile from hepatocyts= collect and drain bile into the bile duct of the portal traid.
  • Digestive function= production of bile
  • Hematologic function= synthesis of plasma proteins
  • Detoxification: alcohol
  • Drug and hormone metabolism; first pass metabolism
  • Metabolic functions: process of nutrients, removing and storing excess nutrients, use of amino acids to make protein or yield energy, break down fatty acids to yield energy, vitamin and mineral storage.
  • Correcting nutrient defiences; regulation circulating levels of glucose, triglycerides, fatty acids and cholesterol. (Blood exiting the liver has less nutrients then entering)
  • Bile breaks down fats
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29
Q

whats the basic anatomy of the liver

A
  • Largest gland
  • Gall bladder rests on the inferior surface of the liver
  • Dual blood supply; haptic artery= oxygenated blood hepatic portal veins= nutrient rich blood
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30
Q

whats the location of the gall bladder

A

inferior surface of liver

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31
Q

whats the function of the gall bladder

A
  • Stores and concentrates unused bile

- Bile is secreted into the duodenm directing from the liver or from that stored in the gall bladder

32
Q

whats the function of the pancreas

A
  • Contains endocrine tissue which scree hormone (insulin and glucagon) into the blood to regulate blood glucose levels
  • Contain cells that produces pancreatic juice= alkaline to neutralise chyme. Contain enzymes
  • Pancreatic jucie release stimulated by pancreases of chyme in the duodenum
33
Q

whats the enzymes and function in the pancreas

A
  • Amylase= breaks down carbohydrates
  • Protease- secreted in inactive form, activates within the duodenum= digest proteins
  • Lipase= digest lipids
  • Nuclease- digest nucleic acids
34
Q

what would happen without a pancreas

A

we would die

35
Q

the process of nutrient absorption for carbohydrates, fat and proteins

A
  • All nutrients other than lipids go to the liver to be processed or stored via the hepatic portal vein
  • Lipids taken via the lacteal to the lymph where it enters the general circulation
  • Small amount of absorption occurs in stomach and large intestine
  • Most absorption occurs in small intestine
  • Destination of nutrients depends on whether the nutrient is water or lipid soluble.
  • Water soluble nutrients (nucleic acids, amino acids) are transports by capillary and designation liver via hepatic portal vein
  • Lipid soluble nutrients (fatty acids, glycerol and bile salts) are transport by lacteal ad destination lymphatic circulation= bloodstream= liver via hepatic artery.
36
Q

define metabolism

A

the sum total of the chemical reaction occurring in an organism

37
Q

define anabolism

A

reactions that build larger molecules from smaller ones eg protein synthesis

38
Q

define catabolism

A

reactions that break down complex structures into simpler ones eg glycogen into glucose.

39
Q

whatsthe two metabolic states called

A

anabolic or avsopritve stae

catabolic or post absorptive state

40
Q

whats anabolic or absorptive state

A

when nutrients are in abundance (drung and for 4 hours after a meal)= anabolism exceeds catabolism and nutrients are used and excesses are stored.
- Allcells need energy to do work ie: active transport, muscle contraction and chemical reactions
- Adenosine triphosphate (ATP) is the molecule that holds the energy within its bonds
- The breakdown of ATP releases energy that the cell uses for work
- Glucose sparing: ATP used by neurons. Skeletal muscles use triglycerides
Cellular respiration process that lead to production of ATP
- Controlled by insulin
- Excess nutrients stored in glucose to glycogen, fatty acids to triglycerides, amino acids to triglycerides

41
Q

whats catabolic or post absoptive state

A

when no food is being digested and body reserves must be broken down to provide nutrients= catabolism exceeds.

  • Fasting state, more than 4 hours after eating
  • Glycogenolysis= breakdown of glycogen to glucse
  • Controlled by glucagon
42
Q

whats peristaltic waves

A

waves of muscular contractions that propel contents from one point to another

43
Q

whats hepatocytes

A

detoxify chemicals, process nutrients and store fat soluble vitamins

44
Q

whats goblet cells

A

secrete mucus

protects mucosa form HCI

45
Q

whats chief cells

A

produce pepsinogen

the inactive form of pepsin

46
Q

whats parietal cells

A

produce HCI, activity pepsin,dentature preen and destroys most bacteria

47
Q

whats carbohydrates broken down into

A

glucose, monosacahrides

48
Q

whats proteins broken into

A

amino acids

49
Q

whats triglycerides broken int

A

glycerol and fatty acids

50
Q

whats glycogenesis

A

making new glycogen (read. backwards)

51
Q

anabolic/absorbsive state
whats the immediate and any excess of glucose
process name

A

immidiate=energy course, ATP
excess= covert to glycogen or triglycerides (fat)
name= gllycogensis

52
Q

anabolic/ absorbive state
whats the intermediate and excess of amino acids
process name

A
intermediate= energy source, ATP
excess= convert to triglycerides (fat)
name= protein synthesis
53
Q

anabolic/absorbsive state
whats the intermediate and excess of glycerol and fatter acids
process name

A
intermediate= energy source and ATP
excess= convert to triglycerides (fat)
name = lipogenesis
54
Q

wheres proteins found

A

all tissues

55
Q

where triglycerides found

A

adipose tissue and liver

56
Q

wheres glycogen found

A

skeletal muscles and liver

57
Q

whats glycogenolysis

A

breaking down glycogen to glucose (lysis=breaking down)

58
Q

whats gluconeogensis

A

converting glucose from glycerol and amino acids

59
Q

what horse is released during the post absorptive state to maintain blood glucose levels

A

glucagon

60
Q

protein in absorptive state

A

All cells → protein synthesis or produce ATP Excess → converted to triglycerides and stored

61
Q

protein in post absobtice state

A

Post Absorptive state breakdown of tissue proteins to release amino acids if prolonged starvation Amino acids used to produce: → glucose and produce ATP if glycogen and fat stores depleted → protein synthesis

62
Q

carbohydrates in absorptive state

A

state All cells → produce ATP Excess → glycogen and stored in liver and skeletal muscle Excess → triglycerides and stored in adipose tissue

63
Q

carbohydrates in post absobitve state

A

Post Absorptive state Blood glucose levels maintained by: → glycogenolysis → gluconeogenesis

64
Q

triglycerides in absorptive state

A

Absorptive state produce ATP stored as fat

65
Q

triglyerciders in post absorptive state

A

state glycerol and fatty acids → glucose and used by cells to produce ATP

66
Q

classes enzymes involved in carbohydrate breakdown

A

mouth: salivary amylases
stomach: no enzyme activity
pancreas: pacreative amylase
small intestine: brush boarder enzymes

67
Q

classes enzymes involved in protein breakdown

A

mouth: no enzyme activity
stomach: pepsin
pancreas: pancreatic protease
small intestine: brush boarder enzymes

68
Q

classes enzymes involved in fat breakdown

A

mouth: no enzyme activity
stomach: no enzyme activity
pancreas: pancreatic lipase
small intestine: no brush board enzymes inovlved

69
Q

classes enzyme involved in nucleic acid breakdown

A

mouth: no enzyme activity
stomach: no enzyme activity
pancreas: pancreatic nuclease
small intestine: brush border enzymes

70
Q

what do the circular folds in the small intestine do

A

slows down the rate at which chyme moves through the small intestine

71
Q

microvilli in small intestine

A

contain brush boarder enzymes

complete digestion of nucleic acids and proteins

72
Q

villi in small intestine

A

absorb nutrients into blood or lymph

73
Q

post absobsive (catabolic state) what happens to proteins

A
proteolysis (process)
amino acids  
gluceongensis (proces)
glucose
energy source to nervous tisssue (result)
74
Q

post absorbive (catabolic state) what happens to glycogen

A

glycogenisis (prcoess)
glucose
energy source to nervous tissue (result)

75
Q

post absorbive state (catabolic state0 what happens to triglycerides

A
lipolysis( process)
1. glycerol 
glucogenisis (process)
glucose
energy source to nervous tissue
2.  fatty acids 
energy source for all other body cellls
76
Q

whats the post absorptive state driven by

A

glucagon

77
Q

when does the post absorptive state occur

A

after not eating fr 4 hours