Module 5 (Immune System) Overview Flashcards

1
Q

Diseases Affected by the Immune System

A

Infectious diseases
Inflammatory diseases
Cancer

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2
Q

Immune System Composition

A

Organs
Cells
Molecules

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3
Q

Microbes

A

Virsues
Bacteria
Fungi
Protozoa

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4
Q

Organs of the immune system

A

Primary

  • Thymus
  • Bone Marrow

Secondary

  • Spleen
  • Lymph nodes
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5
Q

Layers of defence

A

Chemical and physical barriers (skin and mucous membranes)
Innate immunity
Adaptive immunity

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6
Q

Blood composition

A

55% Plasma

  • proteins
  • other solutes
  • water

45% Cells

  • Platelets
  • White Blood Cells
  • Red Blood Cells
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7
Q

Blood cell lineages

A

Erythroid
Myeloid
Lymphoid

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8
Q

Lymphoid Cells

A

T cells

B cells

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9
Q

Types of Myeloid Innate Cells

A

Granulocytes (Neutrophils and Mast cells)
Monocytes - Macrophages
Dendritic Cells
Platelets

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10
Q

Innate Recognition Tools

A

Toll-Like Receptors (TLR)

Pathogen Associated Molecular Pattern (PAMPS)

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11
Q

Common Virus Building Blocks

A

Nucleic acid
ssRNA
dsRNA

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12
Q

Common Bacterial Building Blocks

A

Cell wall
Flagella
Nucleic acid

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13
Q

Inflammation Process

A
  1. Chemical signals = Neutrophilia
  2. Neutrophils stick to capillary walls
  3. Blood vessels dilate and margination occurs
  4. Chemotaxis
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14
Q

Phagocytosis Process

A
  1. Phagocyte adheres to pathogen
  2. Pseaudopods = phagosome formed
  3. Lysosome + phagosome = phagolysosome
  4. Pathogen destroyed
  5. Exocytosis (sometimes)
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15
Q

Complement Activation Pathways

A

Classical
Alternative
Lectin

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16
Q

Complement Functions

A

Opsonise
Recruit
Destroy

17
Q

Soluble Molecules

A

Cytokines

Chemokines

18
Q

Antibody Isotypes

A
IgM
IgG
IgA
IgE
IgD
19
Q

Antibody Functions

A

Opsonisation
Neutralisation
Classical pathway activation

20
Q

Immune responses

A

Primary

Secondary

21
Q

Types of Vaccines

A

Live attenuated
Killed
mRNA subunit
Protein subunit

22
Q

Autoimmune diseases

A

Rhematoid Arthritis
Type 1 Diabetes
Graves