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Concepts in Pathophysiology > Module 6 - Alterations To Haematological Function > Flashcards

Module 6 - Alterations To Haematological Function Flashcards

1
Q

What is anaemia?

A

Reduction in concentration of haemoglobin in blood

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2
Q

What is iron deficiency anaemia?

A

Inadequate iron intake/excessive iron loss

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3
Q

What is pernicious anaemia?

A

Absence of intrinsic factor

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4
Q

What is aplastic anaemia?

A

Failure of bone marrow to produce blood cells

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5
Q

What is renal anaemia?

A

Deficient production of erythrocytes

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6
Q

What is post-haemorrhagic anaemia?

A

Sudden blood loss occurring too quickly

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7
Q

What is thrombocytopenia?

A

Decrease in number of circulating platelets

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8
Q

What is haemophilia?

A

Genetic abnormalities linked to deficient production of clotting factor

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9
Q

What is impaired haemostasis?

A

Inability to promote coagulation and development of stable fibrin clot

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10
Q

What is thromboembolic disorder?

A

Thrombus may form as unwanted clotting factor

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11
Q

What is disseminated intravascular coagulation?

A

Widespread activation of coagulation resulting in formation of fibrin clots

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12
Q

What three factors contribute towards Virchow’s Triad?

A
  1. Injury to blood vessel endothelium
  2. Abnormalities of blood flow
  3. Hyper-coagulability of blood
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13
Q

What is leukaemia?

A

Clonal malignant disorder of blood and blood clotting organs

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14
Q

What is acute leukaemia?

A

Proliferation of undifferentiated/immature cells

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15
Q

What is chronic leukaemia?

A

Predominant cell is mature but does not function properly

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16
Q

What is lymphadenopathy?

A

Enlarged lymph nodes (increased size and number of germinal centres due to proliferation of lymphocytes/monocytes)

17
Q

What are malignant lymphomas?

A

Diverse group of neoplasms that develop from proliferation of malignant lymphocytes

18
Q

What is multiple myeloma?

A

B cell malignancy of bone marrow

19
Q

What are the three types of coagulation disorders?

A

Decreased production of clotting factor (haemophilia)
Inability to promote clotting formation (Vitamin K deficiency)
Thromboembolic disorders (thrombus, PE)

Concepts in Pathophysiology (9 decks)

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