MODULE 6 : AMINO ACID CATABOLISM

Question 0

List of glucogenic amino acids

Answer 0

PYRUVATE
KETOGLUTARATE
SUCCINYL COA
FUMARATE
OXALOACETATE

Question 1

First step in amino acid catabolism

Answer 1

REMOVAL OF AMINO NITROGEN

Except for PROLINE, HYDROXYPROLINE, LYSINE & THREONINE

Question 2

List of ketogenic amino acids

Answer 2

ACETYL CoA

ACETOACETATE

Question 3

Amino acids when catabolized leads to pyruvate

Answer 3

CYS
SER
ALA
GLY
THR
TRP

Question 4

Amino acids when catabolized leads to oxaloacetate

Answer 4

ASP

ASN

Question 5

Amino acids when catabolized leads to ketoglutarate

Answer 5

ARG
GLU
GLN
HIS
PRO

Question 6

Amino acids when catabolized leads to fumarate

Answer 6

PHE
ASP
TYR

Question 7

Amino acids when catabolized leads to Succinyl CoA

Answer 7

VAL
ISO
MET

Question 8

Amino acids when catabolized leads to acety CoA / acetoacetate

Answer 8

ISO
LEU
THR
LYS
PHE
TYR
TRP

Question 9

Failure to catabolize oxalate leads to?

Answer 9

HYPEROXALURIA

Question 10

Alanine is catabolized to pyruvate by what process

Answer 10

TRANSAMINATION

Question 11

Asparagine is hydrolyzed to what amino acid before it is further catabolized to oxaloacetate

Answer 11

ASPARTIC ACID

Question 12

Amino acids used to determine folic acid deficiency

Answer 12

HISTIDINE + FIGLU (N-formiminoglutamate)

Question 13

Enumerate first three steps on the catabolism of branched chain amino acids

Answer 13

1. TRANSAMINATION
2. OXIDATIVE DECARBOXYLATION
3. DEHYDRATION

Question 14

Active form of methionine

Answer 14

SAM

S Adenosyl L Methionine

Question 15

Methionine is converted to ___________ which is then further converted to Succinyl Coa

A. A - ketobutyrate
B. Propionyl Coa
C. Methylmalonyl Coa

Answer 15

A. A - ketobutyrate

Question 16

Isoleucine is converted to ___________ which is then further converted to Succinyl Coa

A. A - ketobutyrate
B. Propionyl Coa
C. Methylmalonyl Coa

Answer 16

B. Propionyl Coa

Question 17

Valine is converted to ___________ which is then further converted to Succinyl Coa

A. A - ketobutyrate
B. Propionyl Coa
C. Methylmalonyl Coa

Answer 17

C. Methylmalonyl Coa

Question 18

____________ is converted to a - keyobutyrate which is then further converted to Succinyl Coa

A. Methionine
B. Isoleucine
C. Valine

Answer 18

A. Methionine

Question 19

____________ is converted to propionyl coa which is then further converted to Succinyl Coa

A. Methionine
B. Isoleucine
C. Valine

Answer 19

B. Isoleucine

Question 20

____________ is converted to methylmalonyl coa which is then further converted to Succinyl Coa

A. Methionine
B. Isoleucine
C. Valine

Answer 20

C. Valine

Question 21

What AA is degraded via the formation of Saccharopine?

Answer 21

Lysine

Question 22

Carbon atoms of side chain and aromatic ring of TRYPTOPHAN is completely degraded via what pathway?

Answer 22

Kynurenine-anthranilate pathway

Question 23

Kynurenine-anthranilate pathway is for degradation of what AA?

A. K
B. Y
C. W
D. S

Answer 23

C. W

Question 24

An iron porphyrin metalloprotein involved in the initial reaction in the degradation of tryptophan

Answer 24

Tryptophan Oxygenase

Question 25

Tryptophan oxygenase is inducible in the liver by?

Answer 25

Adrenal corticosteroid and Tryptophan

Question 26

The action of Tryptophan Oxygenase is inhibited by?

Answer 26

Nicotinic Acid Derivatives (NADPH)

Question 27

This AA is purely Ketogenic

Answer 27

Leucine

Question 28

What are the 3 branched Chain AA? A. KYL B. VIL C. QRE D. FES

Answer 28

B. V I L

Question 29

Aminoacidopathy: Tyrosine Catabolism is impaired

Answer 29

Alkaptonuria

Question 30

Aminoacidopathy: Alkaptonuria: what is the deficient enzyme?

Answer 30

Homogentisate oxidase

Question 31

Aminoacidopathy: Presence of homogentisate in the urine is a character of what condition?

Answer 31

Alkaptonuria

Question 32

Aminoacidopathy: Impaired conversion of F to Y

Answer 32

Phenylketonuria

Question 33

Classic PKU condition has a defect on what enzyme? A. Tetrahydrobiopterin Synthase B. Dihydrobiopterin Synthase C. Phenylalanine Hydroxylase

Answer 33

C. Phenylalanine Hydroxylase

Question 34

Aminoacidopathy: | Results from impaired intestinal and renal transport of neutral AA including W

Answer 34

Hartnup Disease

Question 35

Aminoacidopathy: | Results from the absence of branched chain A - ketoacid dehydrogenase complex

Answer 35

MSUD