Module 8 Flashcards
Which of the following effects may occur when dopamine is administered to patients? A. Increased urinary output. B. Decreased urinary output. C. Increased cardiac output. D. All answers are correct.
D. All answers are correct.
Which of the following drugs would have the highest affinity for its receptor?
A. A drug that has a high maximal efficacy.
B. A drug that is easily displaced from its receptor by another drug.
C. A drug that has a high potency.
D. A drug with minimal intrinsic activity.
C. A drug that has a high potency.
A new drug to treat pain is developed that has a higher intrinsic activity than any other pain relievers on the market. Which statement is correct?
A. The new drug has a higher potency than any of the other drugs.
B. The new drug has a higher maximal efficacy than any of the other drugs.
C. The new drug has a higher affinity than any of the other drugs.
D. The new drug has a lower potency than any of the other drugs.
B. The new drug has a higher maximal efficacy than any of the other drugs.
Which of the following is true of an agonist?
A. They have affinity but no intrinsic activity.
B. They have intrinsic activity but no affinity.
C. Binding of an agonist is unable to decrease a physiological response.
D. They have both affinity and intrinsic activity.
D. They have both affinity and intrinsic activity.
Which of the following would have the highest intrinsic activity? A. Competitive antagonist B. Irreversible antagonist C. Partial agonist D. Allosteric antagonist
C. Partial agonist
Which of the following best describes the simple occupancy theory?
A. The maximum response occurs when 50% of receptors are occupied.
B. The maximal response depends on the intrinsic activity of the drug.
C. The dose response curve is S-shaped with three distinct phases.
D. The number of receptors occupied by the drug determines the intensity of the response.
D. The number of receptors occupied by the drug determines the intensity of the response.
Which of the following is true regarding allosteric antagonists?
A. They cause a parallel rightward shift in the dose response curve.
B. They bind to a different site on the drug receptor than the agonist does.
C. The effect of an allosteric antagonist can be overcome by increasing the dose of agonist.
D. Prolonged exposure to allosteric antagonists may result in receptor desensitization.
B. They bind to a different site on the drug receptor than the agonist does.
Which of the following IS NOT a characteristic of the modified occupancy theory?
A. Two drugs that act at the same receptor will have the same maximal efficacy when all receptor sites are occupied.
B. The intensity of a drug’s response is proportional to the number of receptors occupied.
C. Two drugs occupying the same receptor site may have different binding strengths.
D. Two drugs occupying the same receptor can have a different ability to activate the receptor.
A. Two drugs that act at the same receptor will have the same maximal efficacy when all receptor sites are occupied.
Your patient experiences chronic pain and takes morphine for pain management. The morphine works very well to control the pain however, 6 months after starting on morphine the pain returns. Your patient swears that they are taking their doses as you recommended. What is the most likely explanation?
A. The patient has developed a polymorphism in the enzyme responsible for morphine metabolism.
B. Your patient is lying to you and has likely stopped taking their medication.
C. Your patient is now addicted to morphine so it no longer works to relieve pain.
D. Your patient’s opioid receptors are desensitized.
D. Your patient’s opioid receptors are desensitized.
Your patient is taking morphine to relieve pain following a traumatic accident. You notice that they start to display side effects of morphine including respiratory depression so you give them naloxone. The nalaxone increases respiratory rate but the patient begins to experience pain again. The pain goes away once you restart the morphine. Which of the following is true?
A. Naloxone is an irreversible antagonist and therefore reverses the effects of morphine.
B. Naloxone is a competitive antagonist that reverses the effects of morphine.
C. Naloxone is an allosteric antagonist that reverses the effects of morphine.
D. Naloxone is an agonist of a different receptor.
