Module A Quiz Questions

Question 1

Which of these is not a cardinal sign of inflammation?
Pain
Coolness
Redness
Swelling

Answer 1

Coolness

Question 2

Who developed a vaccine for smallpox?
Koch
Jenner
Pasteur
Fleming

Answer 2

Jenner

Question 3

Which of these is not a secondary lymphoid tissue?
Spleen
Peyer’s patch
Thymus
Lymph node

Answer 3

Thymus

Question 4

Who discovered that silkworm disease can be caused by a fungus?
Semmelweis
Bassi
Koch
Jenner

Answer 4

Bassi

Question 5

Which of the following is an agranulocyte?
Mast cell
Lymphocyte
Basophil
Neutrophil

Answer 5

Lymphocyte

Question 6

Which of these is NOT true of the innate immune system?
It has no memory
It is non-specific
It involves granulocytes
It takes 7 to 10 days to begin a response

Answer 6

It takes 7 to 10 days to begin a response

Question 7

What does TLR-4 primarily recognize?
Lipopolysaccharide
Specific protein antigens
Bound antibodies
Viral nucleic acid

Answer 7

Lipopolysaccharide

Question 8

What type of action do most cytokines produce?
Endocrine
Paracrine
Mesocrine
Autocrine

Answer 8

Paracrine

Question 9

During the oxidative burst, what reactive oxygen species is produced by NADPH oxidase?
Bleach
Nitric oxide
Superoxide
Hydrogen peroxide

Answer 9

Superoxide

Question 10

What term refers to the process where neutrophils leave circulation and enter tissues?
Phototaxis
Viropexis
Apoptosis
Diapedesis

Answer 10

Diapedesis

Question 11

What is the main opsin in the complement cascade?
C5b
C5a
C3a
C3b

Answer 11

C3b

Question 12

What is the function of DAF?
Stabilize C5 convertase
Stabilize C3 convertasae
Degrade C3 convertase
Degrade C5 convertase

Answer 12

Degrade C3 convertase

Question 13

What is the main anaphylatoxin produced in the complement cascade?
C5b
C5a
C3a
C3b

Answer 13

C5a

Question 14

Which complement cascade involves the action of MASPs?
Classical
All of them
Alternative
Lectin-binding

Answer 14

Alternative

Question 15

Which of the complement cascades acts the fastest?
They all act at the same time
Classical
Lectin-binding
Alternative

Answer 15

Alternative

Question 16

Which of these is the C5 convertase of the classical cascade?
C3bBb
C2b4b
C3PO
C2b4b3b

Answer 16

C2b4b3b

Question 17

What is the function of properdin?
Degrade C3 convertase
Degrade C5 convertase
Stabilize C5 convertase
Stabilize C3 convertase

Answer 17

Stabilize C3 convertase

Question 18

Which complement protein forms the pore in the membrane attack complex?
C6
C8
C7
C9

Answer 18

C9

Question 19

Which of these is the C3 convertase of the alternative cascade?
C6789
R2D2
C3bBbP
C2b4B

Answer 19

C3bBbP

Question 20

Which of these is ONLY active in the classical complement cascade?
C1
C4
C2
C3

Answer 20

C1

Question 21

Which of these is involved in antigen presentation of extracellular pathogens?
MHC II and CD-4 T-cells
MHC II and CD-8 T-cells
MHC I and CD-4 T-cells
MHC I and CD-8 T-cells

Answer 21

MHC II and CD-4 T-cells

Question 22

What protein acts as the signalling domain for the B-cell receptor?
Notch
CD-3
TLR-4
Ig alpha and beta

Answer 22

Ig alpha and beta

Question 23

How many different kinds of protein chains make up an antibody structure?
Four
Three
Two
One

Answer 23

Two

Question 24

What isotype of antibody is most important in mucosal defenses?
IgE
IgM
IgD
IgA

Answer 24

IgA

Question 25

Which of the following is NOT a granulocyte? Basophil Eosinophil Mast cell Lymphocyte

Answer 25

Lymphocyte

Question 26

What happens to T-cells during developement if they bind too tightly to MHC antigens? Negative selection Death by neglect Positive selection Activation

Answer 26

Negative selection

Question 27

What cells do the final quality control checks on T-cells in the medulla? Dendritic cells AIRE cTEC Macrophage

Answer 27

AIRE

Question 28

Where do T-cells complete their development? Thallamus Thyroid Bone marrow Thymus

Answer 28

Thymus

Question 29

What is the progression of steps in T-cell development? DN –> DP –> SP DP –> DN –> SP DP –> SP –> DN DN –> SP –> DP

Answer 29

DN –> DP –> SP

Question 30

What enzyme is most important for somatic recombination of T-cell receptors? Notch AID RAG-1 TdT

Answer 30

RAG-1

Question 31

How many ways can a T-cell attempt to make a functional Beta chain? One Two Four Six

Answer 31

Four

Question 32

Elimination of self-reactive T-cell during development is an important part of ____. Allergic responses Peripheral tolerance The blood-brain barrier Central tolerance

Answer 32

Central tolerance

Question 33

What protein acts as the signalling domain for the T-cell receptor? CD-8 TLR-4 CD-4 CD-3

Answer 33

CD-3

Question 34

What happens to T-cells during development if they do not bind at all to MHC antigens? Death by neglect Activation Negative selection Positive selection

Answer 34

Death by neglect

Question 35

What is the most important transcription factor for T-cell development? NFkB Notch Hedgehog FOX-1

Answer 35

Notch

Question 36

Which of the following can arise from both the lymphoid and myeloid cell lines? B-cells Neutrophils T-cells Dendridic cells

Answer 36

Dendridic cells

Question 37

Which of these is true of our innate immunity? Is non-specific Has a memory of past infections Involves antibodies Takes 10 days to get started

Answer 37

Is non-specific

Question 38

What part of our immune defenses is involved in making antibodies? Complement Cellular immunity Humoral immunity Innate immunity

Answer 38

Humoral immunity

Question 39

What cells of the innate immune response eliminate virally infected host cells? Cytotoxic T-cells Helper T-cells NK cells Neutrophils

Answer 39

NK cells

Question 40

Which of these would represent an intracellular pathogen? Staphylococci Virus Amoeba Fungi

Answer 40

Virus

Question 41

RIG-1 is a cytosolic receptor that binds to what? Viral DNA Viral proteins Viral lipids Viral RNA

Answer 41

Viral RNA

Question 42

Which of these is the most important transciption factor for responding to LPS? NFkB Notch RAG-1 HIS-2

Answer 42

NFkB

Question 43

IL-1 is activated by the action of what protein? Caspase-1 Caspase-9 IL-1 TLR-4

Answer 43

Caspase-1

Question 44

Which of these cytokines is secreted in response to viral infection? IL-4 TNF IL-1 Interferon

Answer 44

Interferon

Question 45

What is our immune system’s first line of defense? Skin Neutrophils Complement Antibodies

Answer 45

Skin

Question 46

What process is responsible for most of the diversity in antibody structure? Somatic recombination N nucleotide addition Somatic hypermutation P nucleotide addition

Answer 46

Somatic recombination

Question 47

What chains make up MOST of our T-cell receptors? Alpha and Beta Gamma and Delta Alpha and Gamma Beta and Delta

Answer 47

Alpha and Beta

Question 48

What part of our immune defenses are B-cell associated with? Cell-mediated None of these Humoral Innate

Answer 48

Humoral

Question 49

Which of these is NOT a common function of antibodies? Direct killing of pathogens Opsonization Neutralization Agglutination

Answer 49

Direct killing of pathogens

Question 50

Which of these is involved in antigen presentation of intracellular pathogens? MHC I and CD-4 T-cells MHC II and CD-4 T-cells MHC I and CD-8 T-cells MHC II and CD-8 T-cells

Answer 50

MHC I and CD-8 T-cells