Molecular and Genetic Basis of Tooth Development Flashcards Preview

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Flashcards in Molecular and Genetic Basis of Tooth Development Deck (65)
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1

Neural Crest cells

Stem cells that migrate through defined paths to reach the branchial arches

2

Where are neural crest cells formed?

At the back of the neural tube

3

When doe neural crest cells migrate?

When the neural tube closes at week 4

4

What are the types of division that stem cells undergo?

Symmetric division
Asymmetric division

5

Symmetric division

Stem cells divide into 2 identical stem cells

6

Asymmetric division

Can divide into 1 differentiated cell, and 1 identical stem cell

7

What does it mean for Neural crest cells to be Multipotent stem cells? Why is it important?

Can interact with other cell layers
Embryonic development of the branchial arch structures relies on complicated but precise tissue-tissue interaction

8

NCC-ectoderm interaction

Regulates NCC cells during morphogenesis
Controls the position, size, and shape of organs

9

NCC-mesoderm interaction

Provides environment for NCC cells to populate

10

NCC-endoderm interaction

Develops pharyngeal pouch-generated organs
(thyroid, parathyroid, and thymus)

11

Rhombomeres

Segments of NCC on the neural crest

12

Where do r1-2 migrate?

Branchial arch I

13

Where does r4 migrate?

Branchial arch II

14

Where do r6-7 migrate?

Branchial arch III

15

What rhombomeres make up the Trigeminal nerve?

r1-3

16

What rhombomeres make up the facial nerve?

r4-5

17

What rhombomeres make up the glossopharyngeal nerve?

r6-7

18

What segments do nerves exit from to innervate peripheral target structures?

Even segments (but they collect from all segments)

19

Hox genes

A group of homeobox genes, which possess a unique homeobox (DNA sequence), which encodes a conservative homeodomain (protein segment)

20

What is the protein product if a Hox gene is expressed?

A transcription factor, which controls other gene expression

21

Which NCCs are Hox free?

The ones that migrate to the first branchial arch (r1 and 2)
Hox genes are carried, but just not expressed

22

Which NCCs express Hox?

Ones that migrate to teh second branchial arch and further

23

D1x gene

Family of homeobox genes that produce differences between the maxilla and the mandible

24

D1x1/2 combination

Required for the development of the proximal portion of the first branchial arch (maxillary process)

25

D1x5/6 combination

Required for the development of the distal portion of the first branchial arch (mandibular process

26

D1x1/2 double mutants

Causes a lack of all maxillary molars - mandible is unaffected

27

D1x5/6 double mutants

Lower jaw mirrors the upper jaw

28

What drives the entire process of tooth development?

Interaction between epithelium and mesenchyme

29

What does the epithelium become during tooth development?

Ameloblasts

30

What does the mesenchyme become during tooth development?

Odontoblasts