Molecular Biology: Genetics of Cardiovascular Disease Flashcards Preview

Cardio Week 6 > Molecular Biology: Genetics of Cardiovascular Disease > Flashcards

Flashcards in Molecular Biology: Genetics of Cardiovascular Disease Deck (9):
1

What is the threshold model assumption?

  • What type of heart disease can be attributed to this?

2

What is the criteria to define a multifactoral inheritance risk?

3

What is concordance?

  • What is concordant mean?
  • What does discordant mean?

4

CV Conditions

  • What are the 4 HTN genetic disorders and what mutation is each associated with?

5

What are the 2 genetic cardiomyopathies and what genes are associated with them?

6

What are the genes implicated in long QT syndrome?

7

Familial hyperchylomicronemia aka Burger Grutz

  • What inheritance does it display?
  • What molecule decreased?
  • What happens to TAGs?
  • What location has high incidence?
  • What are 2 conditions assoicated with it?

8

  • What are the 3 monogenic disorders of lipoprotein metabolism that ARE NOT recessive?
    • Which one has PCSK9 implicated?
    • Which one has incomplete dominance?

9

Monogenic Disorders of Lipoprotein Metabolism

  • What are the 3 recessive disprders?
  • Which one affects ApoEe4?
  • Which one affects chylomicron remnants?
  • Which one affects ABCA1 protein?
  • Which one has low HDL levels?
  • Which one affects MTTP?
  • Which one affects vitamin absorption?
  • Which one has star shaped RBCs?