Flashcards in Molecular Medicine II Deck (14):
To be cured by gene therapy, what must the target gene be?
Somatic gene therapy targets what type of cells?
What was the first disease to be 'cured' by gene therapy? What caused this disease?
defective adenine deaminase
What does in vivo gene therapy aim to do?
aims at treating cells directly in the patient
ERBB2 encodes what?
What two facets contribute to a viral delivery system?
aggressive spread and integration
What does ADA breakdown?
How does indirect detection function?
follow a marker associated with a disease
What is a copy number variation (CNV)?
insertion or deletion of chromosomal region
How are CNVs detected?
comparative genome hybridization and FISH
How does comparative genome hybridization become evident?
uneven labeling of template DNA
What does warfarin inhibit?
vitamin K epoxide reductase
A polymorphism in what gene can affect warfarin dosaging?