Molecular Medicine II Flashcards Preview

Biochem V > Molecular Medicine II > Flashcards

Flashcards in Molecular Medicine II Deck (14):
1

To be cured by gene therapy, what must the target gene be?

recessive

2

Somatic gene therapy targets what type of cells?

somatic

3

What was the first disease to be 'cured' by gene therapy? What caused this disease?

SCID

defective adenine deaminase

4

What does in vivo gene therapy aim to do?

aims at treating cells directly in the patient

5

ERBB2 encodes what?

EGFR

6

What two facets contribute to a viral delivery system?

aggressive spread and integration

7

What does ADA breakdown?

deoxyadenosine

8

How does indirect detection function?

follow a marker associated with a disease

9

What is a copy number variation (CNV)?

insertion or deletion of chromosomal region

10

How are CNVs detected?

comparative genome hybridization and FISH

11

How does comparative genome hybridization become evident?

uneven labeling of template DNA

12

What does warfarin inhibit?

vitamin K epoxide reductase

13

A polymorphism in what gene can affect warfarin dosaging?

VKORC1

14

What cytochrome enzyme degrades warfarin?

CYP 2C9