Population Genetics Flashcards Preview

Biochem V > Population Genetics > Flashcards

Flashcards in Population Genetics Deck (15):
1

What does polymorphic mean?

allelic variants present in more than one percent of the population

2

How do consanguineous matings change the gene pool?

increase in homozygote frequency

3

What does linkage disequilibrium mean?

non-random association of alleles at two or more loci

4

In X-linked recessive diseases, what is the allele frequency?

fraction of the males who are affected

5

CFTR heterozygotes carry a protection against?

typhoid

6

Sickle cell anemia carry a protection against?

malaria

7

beta-thalassemia carry a protection against?

malaria

8

Hemochromatosis carry a protection against?

Plague

9

What is assortative mating?

selection of partners based on specific genetic traits

10

Old Order Amish of Lancaster county are susceptible to?

ellis van Creveld disease

11

Ashkenazi jews are susceptible to?

tay sachs

12

French Canadians are susceptible to?

tyrosinemia

13

What does linkage mean?

meiotic recombination between two markers is somewhat unlikely

14

What is linkage disequilibrium?

recombination of two markers is found more frequently than predicted

15

Linkage disequilibrium between a disease allele and a nearby allele is only observed when?

the disease causing mutation was introduced into the population relatively recently