Mood Disorders Flashcards

1
Q

What are the 3 groupings of depression symptoms?

A
  • Core symptoms
  • Biological symptoms
  • Cognitive symptoms
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2
Q

What are the core symptoms of depression?

A
  • Continuous low mood for at least 2 weeks
  • Lack of energy
  • Anhedonia (lack of enjoyment or interest)
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3
Q

What are the common biological symptoms of depression?

A
  • Sleep changes (early morning wakening)
  • Appetite and weight changes
  • Diurnal variation of mood (feel worse in the morning)
  • Psychomotor retardation or agitation
  • Loss of libido
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4
Q

What are the common cognitive symptoms of depression?

A
  • Low self esteem
  • Guilt or self blame
  • Hopelessness
  • Hypochondrial thoughts
  • Poor concentration or attention (impacting on school or work, going as far as to present as pseudodementia)
  • Suicidal thoughts
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5
Q

How is severity of depression diagnosed?

A

Mild = 2 core + 2 others (must be able to function)

Moderate = 2 core + 3/4 others

Severe = 3 core + at least 4 others

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6
Q

What is Psychotic Depression?

A

Diagnosis of Depression + hallucinations (normally a critical voice auditory hallucinations) OR delusions (normally hypochondriacal, guilt, nihilistic, persecutory)

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7
Q

What are the symptoms of hypomania?

A
  • Mildly elevated, expansive or irritable mood
  • Increased energy or activity
  • Increased self esteem
  • Sociability, talkativeness, over familiarity
  • Increased sex drive
  • Reduced need for sleep
  • Difficulty in focussing on one task alone

A diagnosis of hypomania requires several of these with considerable interference of work/social activity for at least several days.

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8
Q

What are the symptoms of mania?

A
  • Elevated, expansive or irritable mood for at least 1 week (often can’t sleep, can’t focus)
  • Increased energy or activity (including agitation)
  • Grandiosity or increased self-esteem
  • Pressure of speech
  • Flight of ideas, racing thoughts
  • Distractible
  • Reduced need for sleep
  • Increased libido
  • Psychotic symptoms such as delusions
  • Spending or giving away money irrationally
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9
Q

Define Cyclothymia?

A
  • Mild periods of elation/depression
  • Early onset and with a chronic course (2+ years)
  • Common in relatives of people with BPD
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10
Q

Define Dysthymia?

A
  • Chronic low mood not fulfilling the diagnostic criteria for depression
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11
Q

What is a mixed affective state?

A

Either a mixture or a rapid alternation (usually within few hours) of hypomanic, manic and depressive symptoms.

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12
Q

How does DSM categorise the forms of BPD?

A

Bipolar 1 =

  • 1+ Manic episodes or mixed episodes
  • With or without depressive episodes

Bipolar 2 =

  • 1+ Depressive episodes AND
  • 1+ Hypomanic episodes
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13
Q

What are the ICD diagnostic criteria for BPD?

A

2+ episodes one of which must be a manic, hypomanic or mixed episode.

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14
Q

What are some differential diagnoses for mood disorders?

A
  • Normal fluctuations in mood
  • Adjustment disorders, bereavement, post-stress reaction
  • Dementia and other brain disorders
  • Personality disorders
  • Anxiety disorders
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15
Q

What physical conditions can cause or present as depression (things to consider for a differential)

A
  • Hypothyroidism

Bare in mind chronic physical conditions, cancer, cardiac issues.

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16
Q

What are the main biological treatments used for mood disorders?

A
  • Antidepressants, mood stabilisers, antipsychotics
  • ECT
  • rTMS (repetitive trans-magnetic stimulation)
  • tDCS (transcranial direct current stimulation
17
Q

What are the indications for ECT?

A
  • Severe depressive illness where other treatments have failed
  • Life threatening illness
  • Prolonged, severe manic episode
  • Catatonia
  • High suicide risk
  • Stupor
  • Severe psychomotor retardation
18
Q

What are the drugs of choice used in bipolar disorder?

A
  • Mood stabilisers e.g. Lithium, sodium valproate
  • Antipsychotics

DO NOT use antidepressants as poor evidence for efficacy and high risk of manic switch

19
Q

How long should patients with depression be treated for?

A

First episode = 6-12 months

Multiple episodes = as long as possible, potentially for life.

20
Q

What are the most important side effects of SSRIs?

A
  • GI upset
  • GI bleeding
  • Sexual dysfunction
  • Dry mouth
  • Anxiety
  • Dizziness