More random past paper qs Flashcards

1
Q

Paediatric paracetamol dosing (under 6)

A

120 mg/5 mL

2-12 months - 2.5 mL
12-24 months - 5 mL
2-4 years - 7.5 mL
4-6 years - 10 mL

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2
Q

Paediatric paracetamol dosing (over 6)

A

250 mg/5 mL

6-8 years - 5 mL
8-10 years - 7.5 mL
10-12 years - 10 mL

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3
Q

Paediatric ibuprofen dosing (for general pain/fever)

A

100 mg/5 mL

3-6 months - 2.5 mL
7-12 months - 2.5 mL up to FOUR times a day
1-3 years - 5 mL
4-6 years - 7.5 mL 
6-9 years - 10 mL
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4
Q

Paediatric ibuprofen dosing (post-immunisation pyrexia)

A

For all children aged 3 and up:
2.5 mL of 100 mg/5 mL, followed by 2.5 mL 6 hours later if required

(If second dose doesn’t work, see GP)

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5
Q

Which administrative route should be avoided when using vinca alkaloids?

A

Intrathecal

should only be administered via IV

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6
Q

What can be given to treat cellulitis (first-line) if the infection is NOT on the face?

A

Flucloxacillin
Clarithromycin/doxycycline if pen allergic
Erythromycin if pregnant

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7
Q

What can be given to treat cellulitis (first-line) if the infection IS on the face (near eyes/nose)?

A

Co-amoxiclav

If unsuitable: clarithromycin with metronidazole

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8
Q

What cautionary label(s) are needed on lansoprazole?

A

Do not take indigestion remedies 2 hours before or after you take this medicine (2)
Take 30 to 60 minutes before food (22)
Swallow this medicine whole. Do not chew or crush (25) - for GR caps only

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9
Q

What is required on a dispensing label for it to be legal?

A
Patient name
Drug name
Instructions for administration
Name and address of dispensary
Date of dispensing
Warning labels
KOOSAROC
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10
Q

What drugs interact with emergency hormonal contraceptives?

A

CYP inducers can reduce their efficacy
Remember: BS CRAP GPS

Barbiturates
St John's Wort
Carbamazepine
Rifampicin
Alcohol (chronic)
Phenytoin
Griseofulvin
Protease inhibitors
Sulfonylureas/Smoking
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11
Q

Which beta-blockers are hydrophilic? What does this mean for their pharmacokinetics and side-effect profile?

A

Celiprolol
Atenolol
Nadolol
Sotalol

Renally excreted (doses should be adjusted in renal impairment)
Less likely to cross the BBB, and therefore less likely to cause nightmares
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12
Q

How many days after UPSI is levonorgestrel (Levonelle) most effective?

A

3 days

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13
Q

How many days after UPSI is ulipristal (EllaOne) effective?

A

5 days

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14
Q

What are some symptoms of hand, foot and mouth disease?

A

Sore throat
Not wanting to eat
Fever

Followed by mouth ulcers and blisters/rashes on palms and soles of feet

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15
Q

How is hand, foot and mouth disease treated?

A

Plenty fluids and OTC paracetamol/ibuprofen

Viral infection so NO antibiotics

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16
Q

What are the monitoring requirements for lithium?

A

Before initiation:
Renal, cardiac and thyroid function
BMI, U&Es, FBC
ECG if pt has CVD/risk factors

Every 6 months:
BMI, U&Es, eGFR, FBC
(more often if evidence of impairment)

Cardiac function - regular

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17
Q

How soon after a lithium dose should levels be taken? What is the target range?

A

12 hours,

0.4 - 1 mmol/L

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18
Q

What should people taking lithium be aware of?

A
Look out for:
Lithium toxicity
Hypothyroidism
Renal dysfunction
Benign intracranial hypertension

May impair skilled tasks

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19
Q

Why shouldn’t thiazide diuretics and lithium be used together?

A

Thiazides can
→ increase risk of HYPOkalaemia
→ increase the plasma conc. of lithium

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20
Q

Are faxed Rxs valid?

A

No - not indelible ink

Pharmacist can use their discretion to mitigate risks and supply, unless CD Sch 2 or 3 (illegal to supply)

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21
Q

What is Zika virus?

A

A disease spread by mosquitos lasting 2-7 days; mild and not harmful (unless pregnant)

NOT a notifiable disease

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22
Q

What electrolyte balances can loop diuretics cause?

A

HYPO everything (K, Na, Mg, Ca)

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23
Q

What electrolyte balances can thiazide diuretics cause?

A

HYPOkalaemia

At higher doses, it can also disrupt:
Na+, uric acid, glucose and lipids

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24
Q

What electrolyte balances can thiazide-like diuretics cause?

A

HYPERcalacaemia

HYPO K, Na and Mg

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25
What electrolyte imbalances can aldosterone antagonists cause?
HYPERkalaemia | HYPO Mg and Na
26
What are levels of renal function as determined by eGFR (mL/min/1.73 m²)?
``` >90 - high 60-89 - mild 45-59 - mild/moderate 30-44 - moderate/severe 15-29 - severe <15 - renal failure ```
27
Who can receive free NHS prescriptions?
``` Aged > 60 Aged < 16 Aged 17/18 and in full-time education On benefits/low income scheme Receiving war pension Medical exemption certificate Pre-paid certificate Pregnant (w/ a maternity exemption certificate) ```
28
Who can receive the flu jab for free?
``` Aged >50 High-risk due to comorbidities Pregnant Live with immunocompromised person(s) Care home residents Healthcare workers ```
29
What are some risk factors of osteoporosis?
``` Post-/ early menopause Long-term use of steroids Old age Low BMI Smoking/drinking Parental Hx of fractures Co-morbidities e.g. RA, diabetes ```
30
BMI ranges :/
<18.5 - underweight 18.5-24.6 - heathy 🤨 25-29.9 - overweight 30-39.9 - obese
31
What happens when naproxen is taken with sertraline?
Increased risk of bleeding | Increased likelihood of hypoNa
32
What happens when naproxen is taken with steroids?
Increased risk of GI bleeding - caution (avoid with [methyl]prednisolone)
33
When are bisphosphonates contraindicated?
Oesophageal abnormalities Hypocalcaemia Factors which delay emptying e.g. stricture ClCr < 35 mL/min
34
When should bisphosphonate use be reviewed?
Every 5 years (3 years with zoledronate)
35
What are the major side effects of amiodarone?
P BITCH 🤭 ``` Photosensitivity Breathing (pulmonary toxicity) Irregular HR (arrhythmia) Thyroid dysregulation Corneal microdeposits Hepatotoxicity ```
36
What interacts with amiodarone?
It's a CYP inhibitor! Warfarin - can increase INR so dose needs to be reduced by 1-2 thirds; monitor Digoxin - can cause toxicity so dose needs to be halved; monitor Also: drugs that cause hypoK/QT prolongation grapefruit juice simvastatin beta-blockers
37
Which statin does not need to be taken at night?
Atorvastatin, due to its longer half life
38
What is oxybutinin?
An antimuscarinic used for urinary frequency, urgency or incontinence
39
Which antidiabetics cause weight gain?
Remember: eating PISza makes you biggger Pioglitazone Insulin Sulfonylureas (gli-)
40
Which antidiabetics cause weight loss?
Remember: Gotta Lose Some Gravity ``` GLP-1s (-glutide) SGLT2 inhibitors (-flozin) ```
41
Which antidiabetics have a high[er] risk of hypoglycaemia?
Insulin | Sulfonylureas (higher in older people)
42
What are some symptoms of hypoglycaemia?
Remember: Plasma SHugar Drops SPLAT ``` Palpitations Sweating Hunger Dizziness Shaky/trembling Pale skin Lips - tingly Anxiety Tiredness ```
43
Why are beta-blockers cautioned in diabetes?
They can mask symptoms of hypoglycaemia
44
Which antipsychotics are more likely to cause weight gain and glucose intolerance?
``` 2nd generation (-pine, -one): quetiapine, clozapine, asenapine, olanzapine risperidone, paliperidone, aripiprazole ```
45
Which antipsychotics are more likely to cause EPSEs and hyperprolactinaemia?
``` 1st generation (-zine, -ol) chlorpromazine, levomepromazine, prochlorperazine haloperidol, flupentixol ``` NOT promethazine (an antihistamine)!
46
How long should a record of a veterinary POM supply be kept for? What needs to be recorded?
5 years ``` Name of medicine Date of receipt/supply Batch no. Name and address of receiver/supplier [Also, keep copy of Rx] ```
47
What is cabergoline?
A dopamine receptor agonist, used to treat hyperprolactinaemia
48
What is donepezil?
An acetylcholinesterase inhibitor used in treatment of dementia
49
A patient who was recently initiated on phenytoin develops a rash. What should you do?
Withdraw; encourage them to seek medical attention [Possible leucopenia - patients should be made aware of symptoms of blood/skin disorders (flu-like symptoms) and report ASAP]
50
Criteria for gradual withdrawal of steriods
> 40 mg OD for ≥ 1 week Repeat evening doses > 3 weeks of treatment Recently repeated courses Short course within 1 year of stopping long term Tx Other possible causes of adrenal suppression
51
Which antiemetic is suitable for use in Parkinson's?
Domperidone (doesn't cross BBB, less EPSEs)
52
What are some MOA inhibitors?
Remember: Mr PITSR ``` Moclobemide Phenelzine Tranylcypromine Selegiline Rasagiline ```
53
What antibiotics can be taken with/after food?
Remember: Molly's Nice Cheesy PIzza Metronidazole Nitrofurantoin Clarithromycin Pivmecillinam
54
What antibiotics should be taken on an empty stomach?
Remember: POFAT ``` Phenoxymethylpenicillin Oxytetracycline Flucloxacillin Azithromycin caps Tetracycline ```
55
What are some examples of aminoglycosides?
Remember: NTAGS ``` Neomycin Teicoplanin Amikacin Gentamicin Streptomycin ```
56
What is the target plasma concentrations for gentamicin and amikacin?
Peak: 5-10 mg/L (3-5 mg/L for endocarditis) Trough >2 mg/L (1 mg/L for endocarditis)
57
Which medicines are ototoxic?
Remember: My Great Cousin [is] Very Very Loud ``` Macrolides Gentamicin Cisplatin Vancomycin Vinca alkaloids Linezolid ```
58
What medicines can increase the concentration of lithium?
Remember: Lily And Stacey Need Managing ``` Loop diuretics ACEis Spironolactone NSAIDs Methotrexate ```
59
Which medicines can cause blood disorders?
Remember: Take Care, Sally-Mae Tacrolimus Co-trimoxazole Sulfasalazine Mesalazine
60
Which cephalosporins are 1st gen?
Remember: cefa- Cefalexin Cefadroxil Cefradine
61
Which cephalosporins are 2nd gen?
Remember: 2 FOXes FOR tea Cefuroxime Cefaclor
62
Which cephalosporins are 3rd gen?
Remember: contains T except cefixime Cetriaxone Cetfotaxime Ceftazidime Cefixime
63
How long should a patient wait before drinking alcohol after a course of metronidazole?
48 hours
64
What two drug classes can increase the risk of side effects of quinolones?
NSAIDs - increase the risk of seizures | Steroids - increase the risk of tendon damage
65
Outline antibiotic treatment for UTIs.
Men: nitrofurantoin OR trimethoprim, 7 days Pregnant women: nitrofurantoin, 7 days waiting for culture? - cefalexin, 7 days Non-pregnant women: nitrofurantoin OR trimethoprim, 3 days Avoid nitro if eGFR < 45
66
Can trimethoprim be taken in renal impairment?
Yes - dose needs to be halved after 3 days if eGFR = 15-30
67
Outline antibiotic treatment for human/animal bites.
1st line: co-amoxiclav PA/CI'd: metronidazole AND doxycycline 3 days for prophyx 5 days for Tx
68
Outline treatment for acute otitis media.
1st line: amoxicillin PA/CI'd: clarithromycin/erythromycin 2nd line: co-amox Tx should last 5-7 days
69
Outline treatment for otitis externa.
1st line: acetic acid 2%, 7 days OR topical neomycin, 7-14 days Cellulitis? - flucloxacillin, 7 days
70
What is the maximum length of time parenteral aminoglycosides can be used for?
7 days
71
Outline treatment for C. difficile infection.
1st line: vancomycin 2nd line: fidaxomicin 3rd line: vanc +/- metronidazole 10 days
72
Trimethoprim interactions
ACEis, ARBs, NSAIDs, diuretics, ciclosporin - increased risk of hyperK Aciclovir - nephrotoxicity SSRIs, NSAIDs, carbamazepine, amitriptyline - increased risk of hypoNa Methotrexate - risk of haematologic SEs e.g. bone marrow suppression