Movement Disorder Drugs Flashcards by Zak Reneau

Q

What is the MOA and disease treated of Levodopa?

A

D2 agonist, PD

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Q

What is the MOA and disease treated of Bromocriptine?

A

D2 agonist, PD

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Q

What is the MOA and disease treated of Ropinirole?

A

D2 agonist, PD

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Q

What is the MOA and disease treated of Pramipexole?

A

D3 agonist, PD

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Q

What is the MOA and disease treated of Carbidopa?

A

DOPA decarboxylase inhibitor, PD

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Q

What are the D2 agonist drugs?

A

Levodopa, Bromocriptine, Ropinirole

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Q

What is the MOA and disease treated of Rasagiline?

A

MAO-B inhibitor, early PD

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Q

What is the MOA and disease treated of Selegiline?

A

MAO-B inhibitor, early PD

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Q

How are Rasagiline and Selegiline different?

A

Rasagiline is more potent

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Q

What is the MOA and disease treated of Entacepone?

A

COMT inhibitor, PD to increase Levodopa

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Q

What is the MOA and disease treated of Tolcapone?

A

COMT inhibitor, PD to increase Levodopa

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Q

What is the MOA and disease treated of Benztropine?

A

Anticholinergic, PD tremors and rigidity

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Q

What is the MOA and disease treated of Biperiden?

A

Anticholinergic, PD tremors and rigidity

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Q

What is the MOA and disease treated of Orphenadrine?

A

Anticholinergic, PD tremors and rigidity

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Q

What is the MOA and disease treated of Procyclidine?

A

Anticholinergic, PD tremors and rigidity

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Q

What is the MOA and disease treated of Trihexyphenidyl?

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A

Anticholinergic, PD tremors and rigidity

Q

What are the Anticholinergic drugs used to treat PD?

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A

Benztropine, Biperiden, Orphenadrine, Procyclidine, Trihexyphenidyl

Q

What is the MOA and disease treated of Reserpine?

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A

Inhibits monoamine transporter causing increased DOPA release, HD

Q

What is the MOA and disease treated of Tetrabenazine

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A

Inhibits monoamine transporter causing increased DOPA release, HD

Q

Which drugs are used to treat HD?

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A

Reserpine, Tetrabenazine

Q

What is the MOA and disease treated of Riluzole?

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A

Inhibits Glutamate release causing inhibition of NMDA receptors, ALS

Q

Which drug is used to treat ALS?

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A

Riluzole

Q

What is the MOA and disease treated of Penicillamine?

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A

Copper chelator, Wilsons

Q

What is the MOA and disease treated of Trientine?

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A

Copper chelator, Wilsons

What is the MOA and disease treated of Potassium Disulfide?

Inhibits GI absorption of Copper, Wilsons

What is the MOA and disease treated of Zince Acetate?

Inhibits GI absorption of Copper, Wilsons

What is the MOA and disease treated of Zinc Sulfate?

Inhibits GI absorption of Copper, Wilsons

What are the drugs that treat Wilsons disease?

Penicillamine, Trientine, Potassium disulfide, Zinc acetate, Zinc sulfate