MS and other demyelinating disease

Question 1

destruction of the myelin sheaths of the nerve fibers with relatively sparing of the other elements of nervous tissue

Answer 1

demyelinating disease of CNS

Question 2

infiltration of inflammatory cells, particularly in a perivenous distribution

Answer 2

demyelinating disease of CNS

Question 3

lesions of demyelinating disease of CNS are primarily in the GRAY MATTER. True or False?

Answer 3

False

esions of demyelinating disease of CNS are primarily in the WHITE MATTER

Question 4

the most common and important inflammatory demyelinating disease

Answer 4

Multiple Sclerosis (MS)

Question 5

MS is a chronic condition, typically characterized by episodes (attacks) of focal disorders of what 3 structures?

Answer 5

MS is a chronic condition, typically characterized by episodes (attacks) of focal disorders of:

Optic nerve
Brain
Spinal Cord

Question 6

Lesions of MS are disseminated in ______ and ______.

Answer 6

Lesions of MS are disseminated in TIME and LOCATION

Question 7

means that there should be at least 2 attacks

Answer 7

Dissemination in TIME

Question 8

means that there should be at least 2 lesions different locations or areas in the nervous system involved

Answer 8

Dissemination in LOCATION

Question 9

Which procedure has the capacity to identify clinically inevident lesions and lesions of different ages.

Answer 9

MRI

Question 10

This procedure helps to demonstrate lesions disseminated in time and location

Answer 10

MRI

Question 11

“Disease of young people”

Answer 11

Multiple Sclerosis

Age onset: 20-40 years old
Very rare: <10 years old and >60 years old

Question 12

Incidence of MS is 2-3x more common in females than in males. True or false?

Answer 12

TRUE

MS is 2-3x more common in FEMALES than in males

Question 13

Increasing or Decreasing?

Prevalence of MS increases with ______ distance from the Equator.

Answer 13

INCREASES

Prevalence of MS increases with INCREASING distance from the Equator with exemptions)

High risk: 40-45 to 60 degrees North and South

Question 14

Japan shares the same latitude as the Northern America. It has the same high incidence in MS. True or False?

Answer 14

FALSE

Japan shares the same latitude as the Northern America. However, it has a LOW incidence in MS

Question 15

Cause of MS

Answer 15

Unknown

Postulated combination of Genetic Susceptibility and Environment, w/ Initial trigger (usually viral infections)–> leads to autoimmune mechanism–> Demyelination

Question 16

On sagittal view of the MRI-T2 Flair images, plaques of MS seem to form _______ projections from the corpus callosum.

Answer 16

FILIFORM/ FINGER-LIKE PROJECTIONS

On sagittal view of the MRI-T2 Flair images, plaques of MS seem to form FILIFORM/ FINGER-LIKE PROJECTIONS from the corpus callosum. Hence, described as DAWSON’S FINGER