MSK: ALLOPURINOL Flashcards Preview

Top 100 Drugs > MSK: ALLOPURINOL > Flashcards

Flashcards in MSK: ALLOPURINOL Deck (5)
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1
Q

ALLOPURINOL: INDICATIONS

A
  • Gout
  • Renal Stones
  • Hyperuricemia
  • Tumour Lysis Syndrome
2
Q

ALLOPURINOL: MOA

A
  • Xanthine Oxidase Inhibitor

- Lowers plasma uric acid concentrations and decreases precipitation of UA in joints/kidneys

3
Q

ALLOPURINOL: ADVERSE EFFECTS

A
  • Skin rash (can be mild or more serious HSRXN = Steven-Johnson Syndrome, Toxic Epidermal Necrolysis)
  • Drug hypersensitivity syndrome = can include fever, eosinophilia, lymphadenopathy and involvement of other organs, such as the liver and skin
  • A can also worsen GOUT attacks
4
Q

ALLOPURINOL: WARNINGS

A
  • Acute attacks of Gout
  • Recurrent skin rash
  • Severe HYPERSENSITIVITY
  • Severe renal/liver impairment
5
Q

ALLOPURINOL: INTERACTIONS

A
  • Mercaptopurine and its pro-drug azathioprine
  • Co-prescription of allopurinol with amoxicillin
  • ACE inhibitors or thiazides

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