MSK/Analgesic Rx

Question 1

Acetaminophen

Answer 1

(Tylenol) non-opioid, non-antiinflammatory analgesic/antipyretic

Question 2

Ibuprofen

Answer 2

(Advil, Motrin) NSAID, analgesic, anti-inflam, antipyretic
MOA: inhibition of prostaglandin synthesis (via cyclooxygenase); prevents formation of thromboxane A2 by platelet aggregation

Question 2

Aspirin

Answer 2

(Zorprin) NSAID, analgesic, anti-inflam, antipyretic
MOA: inhibits synthesis of prostaglandin and thromboxane (via inhibition of cyclooxygenase); inhibits platelet aggregation

Question 3

Naproxen

Answer 3

(Aleve, Naprosyn) NSAID
MOA: inhibition of prostaglandin synthesis (via cyclooxygenase); inhibition of platelet aggregation

Question 4

Celecoxib

Answer 4

(Celebrex) NSAID, analgesic
MOA: COX-2 inhibition that inhibits the conversion of arachidonic acid to prostaglandins but doesn’t effect formation of prostaglandins that mediate homeostasis in GI tract, kidneys and platelets catalyzed by COX-1

Question 5

Diclofenac gel

Answer 5

NSAID

Question 6

Indomethacin

Answer 6

NSAID

Question 7

Ketorolac

Answer 7

NSAID

Question 8

Meloxicam

Answer 8

NSAID

Question 9

Codeine

Answer 9

opioid analgesic, antitussive; opioid agonist
MOA: blocks pain by binding opiate receptors in CNS; antitussive by direct action of medulla

Question 10

Hydrocodone

Answer 10

(Zohydro ER) opioid analgesic, antitussive; opioid agonist

Question 11

Oxycodone

Answer 11

(Oxycontin) narcotic analgesic; opioid agonist

Question 12

Methadone

Answer 12

(Methadose) analgesic, opioid detoxification adjunct; opioid agonist

Question 13

Morphine

Answer 13

opioid analgesic; opioid agonist
MOA: narcotic agonist-analgesic of opiate receptors; inhibits ascending pain pathways; suppresses cough by acting on medulla

Question 14

Fentanyl

Answer 14

opioid

Question 15

Buprenorphine

Answer 15

opioid

Question 16

Tramadol

Answer 16

opioid

Question 17

Naloxone

Answer 17

(Narcan) opioid antagonist; antidote
Indications: Acute opioid overdose & reducing respiratory or mental depression due to opioids

Question 18

Naltrexone

Answer 18

(ReVia) opioid antagonist; antidote
MOA: competitive antagonist at opioid receptor sites (precipitates withdrawal sxs in opioid-dependent individuals)
Indications: Opioid dependence, adjunct to alcohol dependence

Question 19

Prednisone

Answer 19

(Deltasone) corticosteroid; adrenal glucocorticoid
MOA: decreases inflammation by suppression of migration of PMN luekocytes and reversal of increased capillary permeability; suppresses immune system by reducing activity and volume of lymphatic system; suppresses adrenal function at high doses

Question 20

Methylprednisone

Answer 20

(Medrol) corticosteroid; adrenal glucocorticoid
MOA: decreases inflammation by suppression of migration of PMN luekocytes and reversal of increased capillary permeability; suppresses immune system by reducing activity and volume of lymphatic system; suppresses adrenal function at high doses

Question 21

Hydrocortisone

Answer 21

(AHydrocort) intermediate corticosteroid;
MOA: decreases inflammation by suppression of migration of PMN luekocytes and reversal of increased capillary permeability; immunosuppressive effects

Question 22

Dexamethasone

Answer 22

corticosteroid

Question 23

Prednisolone

Answer 23

corticosteroid

Question 24

Alendronate

Answer 24

(Fosamax) bisphosphonate (bone-resorption inhibitor)
MOA: bisphosphonate bind to hydroxyapatite crystals in bone & inhibits bone resorption; decreases mineral release & collagen/matrix breakdown in bone
Indications: prevention & treatment of osteoporosis

Question 25

Raloxifene

Answer 25

(Evista) selective estrogen receptor modulator
MOA: agonist on bone (preventing bone loss); decrease cholesterol & LDL; antagonizes estrogen effects leading to development of breast and uterine cancer
Indications: prophylaxis of postmenopausal osteoporosis; reduce risk of breast cancer in postmenopausal women

Question 26

Denosumab

Answer 26

osteoporosis drug

Question 27

Calcitonin

Answer 27

osteoporosis drug

Question 28

Colchicine

Answer 28

(Colcrys) anti-gout drug; colchicum alkaloid

Question 29

Allopurinol

Answer 29

(Aloprim) anti-gout drug; xanthine oxidase inhibitor

Question 30

Tizanidine

Answer 30

Muscle Relaxant

Question 31

Baclofen

Answer 31

Muscle Relaxant

Question 32

Ketamine

Answer 32

skeletal muscle relaxant? (anesthetic adjunct)
NMDA receptor antagonist

Question 33

Cyclobenzaprine

Answer 33

(Flexiril) skeletal muscle relaxant; autonomic nervous system drug

Question 34

Methocarbamol

Answer 34

skeletal muscle relaxants

Question 35

Carisoprodol

Answer 35

(Soma) skeletal muscle relaxant; carbamate derivative