Role of prostaglandins in inflammation
PGI2, PGD2 and PGE2 are vasodilators
Role of prostaglandins in pain
PGI2 and PGE2 sensitize nerve endings to bradykinin, histamine and substance P
Role of prostaglandins in gastric mucose
Role of prostaglandings in protection of the gastic mucosa
Role of prostaglandins in maintenance of renal blood flow
Role of prostaglandins in platelet aggregation
PGI2 and PGD2 inhibit platelet aggregation
TXA2 stimulates platelet aggregation
___________ (prostaglandin) contracts uterus
__________ keeps ductus arteriosus open following birth.
Where is COX3 primarily found?
Heart and cerebral cortex
3 phases of inflammatory response
- Local vasodilation and increased capillary permeability
- Infiltration of leukocytes and phagocytic cells
- Tissue degeneration and fibrosis occur
Shared characteristics of all NSAIDs
Analgesic, antiinflammatory, and antipyretic
Acetylation of COX-2 retains the COX activity although the reaction produces a different product, _________.