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Flashcards in MSK pharm Deck (12):
1

Role of prostaglandins in inflammation

PGI2, PGD2 and PGE2 are vasodilators

  (edema, erythema)

2

Role of prostaglandins in pain

PGI2 and PGE2 sensitize nerve endings to bradykinin, histamine and substance P

3

Role of prostaglandins in gastric mucose

PGI2

4

Role of prostaglandings in protection of the gastic mucosa

PGI2

5

Role of prostaglandins in maintenance of renal blood flow

PGE2

6

Role of prostaglandins in platelet aggregation

PGI2 and PGD2 inhibit platelet aggregation

TXA2 stimulates platelet aggregation

 

7

___________ (prostaglandin) contracts uterus

PGD2

8

__________ keeps ductus arteriosus open following birth.

PGE2

9

Where is COX3 primarily found?

Heart and cerebral cortex

10

3 phases of inflammatory response

Acute transcient

  • Local vasodilation and increased capillary permeability

Delayed, subacute 

  • Infiltration of leukocytes and phagocytic cells

Chronic proliferative 

  • Tissue degeneration and fibrosis occur

11

Shared characteristics of all NSAIDs

Analgesic, antiinflammatory, and antipyretic

12

Acetylation of COX-2 retains the COX activity although the reaction produces a different product, _________.

15-R-HETE