Musc-Skel Pharmacology Flashcards
This medication if administered in a pulsitile fashion may help in the treatment of osteoporosis (by stimulating osteoblasts). Continuous administration will actually erode bones. It is a synthetic analog of PTH hormone.
Teriperitide- a once daily injection that can only be used for 2 years, then switch over to bisphosphonate to keep the new bone formation.
This medication is a monoclonal antibody that is a RANKL inhibitor, thus inhibits osteoclast development and activity. What drug is at hand?
What is the metabolite in acetaminophen, and why is it toxic?
NAPQI - it depletes glutathione levels in the liver. Without glutathione, AST and ALT levels rise.
Rescue: N-acetylcyseine as it helps regenerate levels of glutathione in the liver.
What type of reaction can Cox-2 inhibitors cause?
Sulfa drug allergy
What is the long term treatment of Rheumatoid arthritis?
Disease Modifying Anti-Rheumatic Drugs (DMARDs):
- Methotrexate (low dose)
- TNF-alpha inhibitors (etanercept, infliximab, adalimumab, certolizumab, golimumab)
What are the three main functions of NSAIDs?
Treat: Reduction of inflammation, reduction of pain, and reduction of fever.
—> anti-inflammatory, analgesia, anti-pyrexia
What is the treatment of choice for acute painful gout?
#1: Indomethacin or an NSAID #2: colchicine #3: oral steroid
What is the treatment of choice for chronic painful gout?
- Allopurinol - inhibits xanthine oxidase (to make UA)
- Probenecid - inhibits reabsorption of uric acid in the PCT (also decr. excretion of penicillin).
-Feboxustat - inhibits xanthine oxidase as well.
What is the treatment for seronegative spondylar arthropathies?
TNF-alpha inhibitor drugs
What is the MOA of TNF-alpha drugs? What is a common side effect?
Bind to TNF-alpha, thus prevents it from activating the immune system.
SE: since they inhibit the immune system, they are at increased risk for infection, thus has the possibility of reactivating latent TB, so must check a PDD before administering.
This disease affects children (onset before age 10), persistent joint swelling (synovial thickening, accumulation of synovial fluid). There are 3 different subtypes. What is the disease, and the 3 subtypes?
Juvenile Idiopathic Arthritis
- Polyarticular JIA
- Pauciarticular JIA
- Systemic-onset JIA
This type of Juvenile Idiopathic Arthritis presents with severe symmetrical arthritis, dactylitis. Which subtype is at hand?
This type of Juvenile Idiopathic Arthritis typically involves large joints; 20-25% have uveitis. Which subtype is at hand?
This type of Juvenile Idiopathic Arthritis begins with systemic symptoms (fever, rash, elevated WBC, anemia, hepatosplenomegaly, lymphadenopathy); arthritis later. Which subtype is at hand?
What medications cause drug induced Lupus, and what antibody is associated with this pathology?
SHIPP: Sulfonamides Hydralazine Isoniazid Phenytoin Procainamide