Musc-Skel Pharmacology Flashcards Preview

Musculo-Skeletal > Musc-Skel Pharmacology > Flashcards

Flashcards in Musc-Skel Pharmacology Deck (23)
Loading flashcards...
1

This medication if administered in a pulsitile fashion may help in the treatment of osteoporosis (by stimulating osteoblasts). Continuous administration will actually erode bones. It is a synthetic analog of PTH hormone.

Teriperitide- a once daily injection that can only be used for 2 years, then switch over to bisphosphonate to keep the new bone formation.

2

This medication is a monoclonal antibody that is a RANKL inhibitor, thus inhibits osteoclast development and activity. What drug is at hand?

Denosumab

3

What is the metabolite in acetaminophen, and why is it toxic?

NAPQI - it depletes glutathione levels in the liver. Without glutathione, AST and ALT levels rise.

Rescue: N-acetylcyseine as it helps regenerate levels of glutathione in the liver.

4

What type of reaction can Cox-2 inhibitors cause?

Sulfa drug allergy

5

What is the long term treatment of Rheumatoid arthritis?

Disease Modifying Anti-Rheumatic Drugs (DMARDs):
-Methotrexate (low dose)
-Hydroxyquinolone
-Sulfasalazine
-TNF-alpha inhibitors (etanercept, infliximab, adalimumab, certolizumab, golimumab)

6

What are the three main functions of NSAIDs?

Treat: Reduction of inflammation, reduction of pain, and reduction of fever.
—> anti-inflammatory, analgesia, anti-pyrexia

7

What is the treatment of choice for acute painful gout?

#1: Indomethacin or an NSAID
#2: colchicine
#3: oral steroid

8

What is the treatment of choice for chronic painful gout?

-Allopurinol - inhibits xanthine oxidase (to make UA)
-Probenecid - inhibits reabsorption of uric acid in the PCT (also decr. excretion of penicillin).

-Feboxustat - inhibits xanthine oxidase as well.

9

What is the treatment for seronegative spondylar arthropathies?

NSAIDs
Steroids
DMARDs
TNF-alpha inhibitor drugs

10

What is the MOA of TNF-alpha drugs? What is a common side effect?

Bind to TNF-alpha, thus prevents it from activating the immune system.

SE: since they inhibit the immune system, they are at increased risk for infection, thus has the possibility of reactivating latent TB, so must check a PDD before administering.

11

This disease affects children (onset before age 10), persistent joint swelling (synovial thickening, accumulation of synovial fluid). There are 3 different subtypes. What is the disease, and the 3 subtypes?

Juvenile Idiopathic Arthritis
-Polyarticular JIA
-Pauciarticular JIA
-Systemic-onset JIA

12

This type of Juvenile Idiopathic Arthritis presents with severe symmetrical arthritis, dactylitis. Which subtype is at hand?

Polyarticular JIA

13

This type of Juvenile Idiopathic Arthritis typically involves large joints; 20-25% have uveitis. Which subtype is at hand?

Pauciarticular JIA

14

This type of Juvenile Idiopathic Arthritis begins with systemic symptoms (fever, rash, elevated WBC, anemia, hepatosplenomegaly, lymphadenopathy); arthritis later. Which subtype is at hand?

Systemic-onset JIA

15

What medications cause drug induced Lupus, and what antibody is associated with this pathology?

SHIPP:
Sulfonamides
Hydralazine
Isoniazid
Phenytoin
Procainamide

16

What is the treatment for Lupus? What is the treatment for advanced Lupus?!

Steroids
NSAIDs
Hydroxychloroquine

Advanced Lupus:
Cyclophosphamide

17

What are the medications that can cause Steven-Johnson Syndrome?

-Anti-convulsants: CLEPP
(Carbamazepine, lamotragine, ethosuximide, Phenytoin, phenobarbital)
-Sulfa drugs
-Penicillin
-Allopurinol

18

What are the medications that can cause Steven-Johnson Syndrome?

-Anti-convulsants: CLEPP
(Carbamazepine, lamotragine, ethosuximide, Phenytoin, phenobarbital)
-Sulfa drugs
-Penicillin
-Allopurinol

19

What is the max dose of acetaminophen (grams/day)?

4g/day

20

What is the treatment of osteoarthritis?

-Acetaminophen
-NSAIDs
-Steroids (intraarticular)
-Hyaluronic acid (intraarticular)
-Opioids
-Joint replacement

21

What are the 4 MC TNF-alpha drugs?

Etanercept, Infliximab, Adalimumab, Golimumab, Certolizumab

22

What drugs and diseases cause a decrease in Uric Acid excretion?

-Use of Thiazide or loop diuretic
-Lesch Nyhan Syndrome
-Treatment for leukemia or lymphoma (increasing cell turnover and tumor lysis causing increased UA)

23

How does N-acetylcysteine act as an antidote for acetaminophen overdose.

Regeneration of glutathione