Musculoskeletal V- Fractures, Pharmacology, Terminology Flashcards
(39 cards)
Nonopiod agents- Action
- nonopiod agents provide analgesia and pain relief, produce anti inflammatory effects, and initiate anti-pyretic (reduces fever) properties
- these drugs promote a reduction of prostaglandin formation that decreases the inflammatory process , decreases uterine contractions, lowers fever, and minimizes impulse formation of pain fibers
Nonopiod agents- Indications
- mild to moderate pain at various origins; fever, headache, muscle ache, inflammation (except acetaminophen), primary dysmenorrhea, reduction of risk of MI (aspirin only)
Nonopiod agents- Side effects
- nausea, vomting, vertigo, abdominal pain, GI distress or bleeding, ulcer formation, potential for Reye syndrome in children (aspiring only)
- Reye- A rare but serious condition that causes confusion, swelling in the brain, and liver damage.
Nonopiod agents- Implications for PT
- patients are at increased risk for masked pain that would allow for movement beyond limitation or false understanding of their level of mobility
- complaints of stomach pain should be taken seriously with subsequent referral to a physician
Nonopiod agents- Examples
- Tylenol (acetaminophen); Non steroidal anti inflammatories (NSAIDs); Aspirin (acetylsalicylic acid), Aleve (naproxen), Advil (ibuprofen), Celebrex (celecoxib)
Opioid agents (Narcotics)- Action
- opioid agents provide analgesia for acute severe pain management
- medication stimulates opioid receptors within the CNS to prevent pain impulses from reaching their destination
- certain drugs are also used to assist with dependency and withdrawal symptoms
Opioid agents (Narcotics)- Indications
- moderate to severe pain of various origins, induction of conscious sedation prior to a diagnostic procedure, management of opioid dependence, relief of severe and persistent cough (codeine)
Opioid agents (Narcotics)- Side effects
- mood swings, sedation, confusion, vertigo, dulled cognitive function, orthostatic hypotension, constipation, incoordination, physical dependence, tolerance
Opioid agents (Narcotics)- Implications for PT
- therapist must monitor the patient for potantial side effects, especially signs of respiratory depression
Opioid agents (Narcotics)- Examples
- Roxanol (Morphine), Demerol (Meperidine), OxyContin (oxycodone), Sublimaze (fetanyl), Paveral (Codeine)
Glucocorticoid agents (Corticosteroids)- Action
- provide hormonal, anti-inflammatory, and metabolic effects including suppresion of articular and systemic diseases
- these agents reduce inflammation in chronic conditions that can damage healthy tissue through a series of reactions
- vasoconstriction results from stabilizing lysosomal membranes and enhancing the effects of catecholamines
Glucocorticoid agents (Corticosteroids)– Indications
- replacement therapy for endocrine dysfunction, anti inflammatory and immunosuppresive effects; treatment of rheumatic, respiratory, and various other disorders
Glucocorticoid agents (Corticosteroids)- Side effects
- muscle strophy, GI distress, glaucoma, adrenocortical suppression, drug-induced Cushing syndrome, weakening with breakdown of supporting tissues (bone, tendon, ligament, skin), mood changes, hypertension
Glucocorticoid agents (Corticosteroids)- Implications for PT
- therapist must wear a mask when working with patients on glucocorticoid therapy since their immune system is weakened
- patients are at risk for opsteoporosis and muscle wasting
- treatment of an injected joint will require special care due to ligament and tendon laxity or weakening
Glucocorticoid agents (Corticosteroids)- Examples
- Dermacort (hydrocortisone or cortisol), Cordrol (prednisone), Pediapred (predisolone), Medrol (methylprednisolone), Decadrol (dexamethasone)
Disease-modifying anti-rheumatic agents- Action
- DMARDs slow or halt the progression of rheumatic disease
- used early during the disease process to slow the progression prior to widespread damage of the affected joints
- they act to reduce remission by modifying the pathology and inhibiting the immune response responsible for rheumatic disease
Disease-modifying antirheumatic agents- Indications
- rheumatic disease, preferably during early treatment
Disease-modifying anti-rheumatic agents- Side effects
- nausea, headache, joint pain swelling, toxicity, GI distress, sore throat, fever, liver dysfunction, hair loss, potential for sepsis, retinal damage
Disease-modifying anti-rheumatic agents- Implications for PT
- therapists should recognize that many of the agents have a high incidence of toxicity
Avulsion fracture
- portion of a bone becomes framented at the site of tendon attachment due to a traumatic and sudden stretch of the tendon

Closed fracture
- break in a bone where the skin over the site remains intact

Comminuted fracture
- bone that breaks into fragments at the site of injury

Compound fracture
- a break in a bone that protrudes through the skin

Greenstick fracture
- break on one side of a bone that does not damage the periosteum on the opposite side
- often seen in children
