Muskuloskeletal and Pain

Question 1

How long does it take to see the effect of Allopurinol?

Answer 1

2 to 3 days

Question 2

How long does it take to see the effect of Febuxostat?

Answer 2

2 weeks

Question 3

What are Febuxostat, Allopurinol and Colchicine used to treat?

Answer 3

Gout

Question 4

Can probenecid and sulfinpyrazone be used for acute attacks of gout?

Answer 4

No

Question 5

How are gout drugs metabolized and excreted?

Answer 5

Metabolized in the liver, excreted in urine

Question 6

Can anti-gout drugs be prescribed to patients with renal impairment?

Answer 6

Yes, but cautiously

Question 7

What pregnancy category are allopurinol, colchicine, and febuxostat?

Answer 7

Pregnancy category C

Question 8

What pregnancy category is Probenecid?

Answer 8

Pregnancy category B

Question 9

What pregnancy category is Sulfinpyrazone?

Answer 9

Pregnancy category D

Question 10

Which antigout drugs may cause hepatotoxicity?

Answer 10

Allopurinol and colchicine

Question 11

Which antigout drug can cause significant diarrhea?

Answer 11

Colchicine

Question 12

Which antigout drugs may cause problems to a patient with a sulfa allergy?

Answer 12

Probenecid and sulfinpyrazone

Question 13

Which antigout drug may cause a maculopapular skin rash, especially in renal patients?

Answer 13

Allopurinol

Question 14

Which antigout drug may cause a patient to develop weakness related to myopathy and neuropathy?

Answer 14

Colchicine

Question 15

Which antigout drug is associated with vitamin B12 malabsorption?

Answer 15

Colchicine

Question 16

Which antigout drug has few drug-drug interactions?

Answer 16

Colchicine

Question 17

Which antigout drugs have lots of drug-drug interactions?

Answer 17

Probenecid, allopurinol, and sulfinpyrazone

Question 18

Which antigout drug increases the plasma levels of most penicillins and cephalosporins?

Answer 18

Probenecid

Question 19

Which antigout drug is the first choice for acute gout attacks?

Answer 19

Colchicine

Question 20

Which antigout drug is the drug of choice for prevention or urinary calculi?

Answer 20

Allopurinol

Question 21

Which antigout drug does NOT require a renal dose adjustment?

Answer 21

Febuxostat

Question 22

Which antigout drug is used for patients with chronic gout and hyperuricemia?

Answer 22

Febuxostat

Question 23

What drugs are also given during the first six months of febuxostat therapy?

Answer 23

NSAIDs or colchicine

Question 24

When is probenecid therapy started?

Answer 24

After the acute gout attack has resolved

Question 25

Why would you wean a patient off of probenecid?

Answer 25

Either the patient has had no gout attacks for six months or the patient's uric acid levels have begun to rise

Question 26

What is the last resort antigout drug when both probenecid and allopurinol are not tolerated?

Answer 26

Sulfinpyrazone

Question 27

What should be closely monitored in all antigout drugs?

Answer 27

Serum uric acid levels

Question 28

What should be periodically monitored in patients taking probenecid and sulfinpyrazone and why?

Answer 28

CBC for blood dyscrasias

Question 29

What is the pregnancy category for corticosteroids?

Answer 29

Pregnancy category C

Question 30

Why are corticosteroids contraindicated in people with active untreated infections?

Answer 30

The drug may mask the signs and symptoms of the infection

Question 31

What is the best time of day to take corticosteroids?

Answer 31

In the morning before 9 am

Question 32

Why should a patient get an eye exam before beginning long-term corticosteroid treatment?

Answer 32

To check for cataracts and glaucoma

Question 33

Which NSAID or NSAID-like medication does not cause GI upset?

Answer 33

Acetominophen

Question 34

What is the pregnancy category of most NSAIDs?

Answer 34

Pregnancy category B or C

Question 35

At what point in the pregnancy should all NSAIDs be avoided?

Answer 35

the last trimester

Question 36

What pregnancy category is acetaminophen?

Answer 36

Pregnancy category B

Question 37

Which NSAID or NSAID-like medication irreversibly inhibits platelet aggregation?

Answer 37

Aspirin and salicylates

Question 38

How soon before surgery should a patient stop taking aspirin?

Answer 38

1 week before

Question 39

What is the pregnancy category of aspirin?

Answer 39

Pregnancy category D

Question 40

What drug therapies are recommended for acute visceral pain?

Answer 40

corticosteroids and NSAIDs

Question 41

Which NSAID or NSAID-like drug is SAFE for infants, pregnant patients and most elderly patients?

Answer 41

Acetaminophen

Question 42

What type of drug interactions should the NP be aware of when prescribing Celebrex or any other COX 2 inhibitors?

Answer 42

It is metabolized in the CYP portion of the liver

Question 43

What is the pregnancy category for opioid analgesics?

Answer 43

Pregnancy category C

Question 44

What are the names of the three opioid antagonists?

Answer 44

Narcan, Revia, and Revex

Question 45

What is the usual treatment for non-neuropathic pain?

Answer 45

NSAIDs

Question 46

What is the usual treatment for neuropathic pain?

Answer 46

Anti-epileptics such as Carbamazepine, Gabapentin, and Pregabalin

Question 47

Which antidepressants are often used to treat pain?

Answer 47

Tricyclic antidepressants such as amitryptiline

Question 48

How long does it take for pain to diminish when the patient is being treated with tricyclic antidepressants?

Answer 48

Several weeks