Myelocytic Series Flashcards

1
Q

Myelocytic Series

A

Granulocytic Series

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2
Q

Myeloblast

A

-Cell size: 12-20 um
-N/C ratio 4:1
-Round-oval nucleus,
“rounded refrigerator corners” *
-Central or eccentric nucleus
-Light red-purple fine meshwork chromatin with no aggregation of material
-1-5 nucleoli*
-Scanty basophilic cytoplasm
-No granules
-May contain Auer rods

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3
Q

Identify

A

Myeloblast

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4
Q

Identify

A

Myeloblast

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5
Q

Promyelocyte

A

-Cell size: 15-23 um
-N/C ratio 3:1
-Round-oval nucleus,
-Central or eccentric nucleus
-Light red-purple fine meshwork c-chromatin, possibly slight aggregation at nuclear membrane
-1-3 nucleoli
-Basophilic cytoplasm (may be slightly increased over blast)
-Coarse azurophilic nonspecific (primary) granules*

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6
Q

Identify

A

Promyelocyte

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7
Q

Identify

A
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8
Q

Myelocyte

A

-Cell size: 10-18 um
-N/C ratio 2:1 or 1:1
-More round-oval nucleus*
-Central or eccentric nucleus
-Red-purple fine chromatin with slightly aggregated pattern*
-May or may not have nucleoli
-Moderate bluish - pink
cytoplasm
-nonspecific (primary) and
specific (secondary) granules*

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9
Q

Identify

A

Myelocyte

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10
Q

Identify

A

Myelocyte

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11
Q

Metamyelocyte

A

-Cell size: 10-18 um
-N/C ratio 1:1
-Indented (kidney shaped) nucleus*
-Central or eccentric nucleus
-Light blue-purple with chromatin c-clumps easily distinguishable
-No nucleoli
-Moderate bluish - pink cytoplasm
(occasionally clear pink)
-Specific (secondary) granules
(few non-specific)

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12
Q

Identify

A

Metamyelocyte

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13
Q

Identify

A

Metamyelocyte and PMN

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14
Q

Band Neutrophil

A

-Cell size: 10-16 um
-N/C ratio 1:1
-Elongated narrow band shape of uniform thickness, singular lobe*
-Central or eccentric nucleus
-Deep blue-purple coarsely
granular nuclear chromatin
(distinct parachromatin)
-No nucleoli
-Abundant pink cytoplasm
-Fine violet-pink specific granules

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15
Q

Identify

A

Band Neutrophil

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16
Q

Polymorphonuclear Segmented Neutrophil

A

Cell size: 10-16 um
N/C ratio 1:1
2-5 distinct nuclear lobes
(filament connecting lobes) *
Central or eccentric nucleus
Deep blue-purple coarsely
granular nuclear chromatin
(distinct parachromatin)
No nucleoli
Abundant pink cytoplasm
Fine violet-pink specific granules

17
Q

Identify

A

Polymorphonuclear Segmented neutrophil

18
Q

Eosinophil

A

Red Granulated Cell

19
Q

Basophil

A
20
Q

Basophil

A
21
Q

Leukomoid Reaction

A

-Transient, reactive condition characterized by moderate to severe increased WBC and a
Shift to the Left
(increased immature granulocytes in blood)
*Infection
*Physiological leukocytosis

22
Q

WBC Malignancies

A

Malignant (cancerous) condition often characterized by moderate to severe increased WBC

These general malignant conditions may have a
* Shift to the Left (immature granulocytes in the peripheral blood) depending on the specific disease process…
*Leukemias
*Myelodysplastic Syndromes