Myelocytic Series

Question 1

Myelocytic Series

Answer 1

Granulocytic Series

Question 2

Myeloblast

Answer 2

-Cell size: 12-20 um
-N/C ratio 4:1
-Round-oval nucleus,
“rounded refrigerator corners” *
-Central or eccentric nucleus
-Light red-purple fine meshwork chromatin with no aggregation of material
-1-5 nucleoli*
-Scanty basophilic cytoplasm
-No granules
-May contain Auer rods

Question 3

Identify

Answer 3

Myeloblast

Question 4

Identify

Answer 4

Myeloblast

Question 5

Promyelocyte

Answer 5

-Cell size: 15-23 um
-N/C ratio 3:1
-Round-oval nucleus,
-Central or eccentric nucleus
-Light red-purple fine meshwork c-chromatin, possibly slight aggregation at nuclear membrane
-1-3 nucleoli
-Basophilic cytoplasm (may be slightly increased over blast)
-Coarse azurophilic nonspecific (primary) granules*

Question 6

Identify

Answer 6

Promyelocyte

Question 7

Identify

Answer 7

Question 8

Myelocyte

Answer 8

-Cell size: 10-18 um
-N/C ratio 2:1 or 1:1
-More round-oval nucleus*
-Central or eccentric nucleus
-Red-purple fine chromatin with slightly aggregated pattern*
-May or may not have nucleoli
-Moderate bluish - pink
cytoplasm
-nonspecific (primary) and
specific (secondary) granules*

Question 9

Identify

Answer 9

Myelocyte

Question 10

Identify

Answer 10

Myelocyte

Question 11

Metamyelocyte

Answer 11

-Cell size: 10-18 um
-N/C ratio 1:1
-Indented (kidney shaped) nucleus*
-Central or eccentric nucleus
-Light blue-purple with chromatin c-clumps easily distinguishable
-No nucleoli
-Moderate bluish - pink cytoplasm
(occasionally clear pink)
-Specific (secondary) granules
(few non-specific)

Question 12

Identify

Answer 12

Metamyelocyte

Question 13

Identify

Answer 13

Metamyelocyte and PMN

Question 14

Band Neutrophil

Answer 14

-Cell size: 10-16 um
-N/C ratio 1:1
-Elongated narrow band shape of uniform thickness, singular lobe*
-Central or eccentric nucleus
-Deep blue-purple coarsely
granular nuclear chromatin
(distinct parachromatin)
-No nucleoli
-Abundant pink cytoplasm
-Fine violet-pink specific granules

Question 15

Identify

Answer 15

Band Neutrophil

Question 16

Polymorphonuclear Segmented Neutrophil

Answer 16

Cell size: 10-16 um
N/C ratio 1:1
2-5 distinct nuclear lobes
(filament connecting lobes) *
Central or eccentric nucleus
Deep blue-purple coarsely
granular nuclear chromatin
(distinct parachromatin)
No nucleoli
Abundant pink cytoplasm
Fine violet-pink specific granules

Question 17

Identify

Answer 17

Polymorphonuclear Segmented neutrophil

Question 18

Eosinophil

Answer 18

Red Granulated Cell

Question 19

Basophil

Answer 19

Question 20

Basophil

Answer 20

Question 21

Leukomoid Reaction

Answer 21

-Transient, reactive condition characterized by moderate to severe increased WBC and a
Shift to the Left
(increased immature granulocytes in blood)
*Infection
*Physiological leukocytosis

Question 22

WBC Malignancies

Answer 22

Malignant (cancerous) condition often characterized by moderate to severe increased WBC

These general malignant conditions may have a
* Shift to the Left (immature granulocytes in the peripheral blood) depending on the specific disease process…
*Leukemias
*Myelodysplastic Syndromes