Myocarditis and Pericarditis Flashcards

(72 cards)

1
Q

What are the types of cardiomyopathy?

A

Hypertrophic
Dilated
Restrictive
Obliterative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is hypertrophic cardiomyopathy?

A

Inappropriate ventricular hypertrophy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the distribution of hypertrophic cardiomyopathy?

A

Asymmetric septal hypertrophy
Apical hypertrophy
Generalised hypertrophy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the genetic features of hypertrophic cardiomyopathy?

A

Usually autosomal dominant, familial condition
Sporadic cases
Genetic heterogeneity - over 30 different genetic variants described
Phenotypic heterogeneity - expression varies even within families who have the same genes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What do genes affected by hypertrophic cardiomyopathy control?

A

Contractile porteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What interaction is abnormal in beta myosin heavy chains in hypertrophic cardiomyopathy?

A

Abnormal interaction between actin and myosin filaments

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

When does hypertrophic cardiomyopathy usually manifest?

A

Early to mid teenage years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the effect of hypertrophic cardiomyopathy on ventricular contraction?

A

Normal or increased in the majority of patients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the effect of hypertrophic cardiomyopathy on systole and diastole?

A

Systole - LVOT obstruction

Diastole - reduced compliance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is a common effect on relaxation in hypertrophic cardiomyopathy?

A

Impaired relaxation is a common feature

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the effect of hypertrophic cardiomyopathy on systolic function?

A

Usually adequate with some functional abnormality

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

In what percentage of people with hypertrophic cardiomyopathy is the cause genetic?

A

90%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the effect of hypertrophic cardiomyopathy on diastolic function?

A

Impaired with poor capacity to fill and reduced cardiac compliance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the pathology of hypertrophic cardiomyopathy?

A

Myocyte hypertrophy and disarray
Can be generalised or segmented with wall thickness
Coronary arteries are also affected with small vessel narrowing and consequent ischaemia and fibrosis
Arrhythmias common

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is dilated cardiomyopathy?

A

Effectively a structural and functional description, ventricular function is impaired - usually affects the left ventricle but all 4 chambers can be dilated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the features of dilated cardiomyopathy?

A

Cardiac enlargement
Reduced contraction of one or both ventricles
Progressive and irreversible condition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is the mortality of dilated cardiomyopathy?

A

25% 1 year mortality

50% 5 year mortality

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is the aetiology of dilated cardiomyopathy?

A

Common expression of myocardial damage, probably due to a number of different disease processes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What are the features of restrictive and infiltrative cardiomyopathy?

A

Less common
Systolic function may or may not be impaired
About 50% related to specific clinical disorders
Non-compliant heart so fills poorly regardless of systolic function which has a profound effect on haemodynamics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What are the non-infiltrative causes of cardiomyopathy?

A

Familial
Scleroderma
Diabetes
Pseudoxanthoma elastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What are the infiltrative causes of cardiomyopathy?

A

Amyloid

Sarcoid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What are the storage diseases which cause cardiomyopathy?

A

Haemochromatosis

Fabry disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What are the endomyocardial causes of cardiomyopathy?

A

Fibrosis
Carcinosis
Radiation
Drug effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What is the pathology of dilated cardiomyopathy?

A

Inability to fill a ventricle which has a reduced compliance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
When is alcohol heart disease potentially reversible?
In early stages with immediate and complete abstinence
26
What is myocarditis?
Involvement of the heart in an inflammatory process, usually caused by an infective agent
27
What infective agents cause myocarditis?
``` Toxins Drugs Allergic reactions Vasculitic disorders Viral Ricketsia Bacteria Fungi Protozoa Metazoan Spirochaetes ```
28
What is the clinical course of myocarditis?
Usually a self-limiting sub-clinical condition during the course of a viral infection Can develop into acute and fulminating heart failure
29
What are the common pericardial diseases?
Acute pericarditis Pericardial effusion Constrictive pericarditis
30
What is acute pericarditis?
Acute inflammation of the pericardium
31
What are the causes of acute pericarditis?
``` MI Infective Neoplastic Myxoedema Autoimmune Radiation Viral Bacterial - tuberculosis Rheumatoid arthritis Systemic lupus Scleroderma Dressler's syndrome ```
32
What are the types of neoplastic pericarditis?
Direct infiltration - lung, breast, Hodgkin's disease | Radiation pericarditis - delayed onset, 4 months to 20 years
33
What are the features of acute pericarditis?
Chest pain - eased by leaning forward | Friction rub
34
What are the potential complications of acute pericarditis?
Chronic relapsing pericarditis Pericardial effusion Pericardial tamponade Pericardial constriction
35
What is pericardial effusion?
Collection of fluid in the cavity which lies between the two layers of pericardium
36
What are the features of pericardial effusion?
Muffled heart sounds Abnormal JVP Well tolerated if small
37
What is the management of pericardial effusion dependent on?
Cause
38
What is pericardial tamponade?
Large pericardial effusion
39
What are the features of pericardial tamponade?
``` Cardiac compression, especially of the right ventricle Reduction in cardiac output Medical emergency Tachycardia Hypotension Oliguria Elevated JVP Pulsus paradoxus Kussmaul sign ```
40
What is the management of pericardial tamponade?
Demands urgent drainage - pericardiocentesis, percutaneous balloon pericardiotomy, pericardial resection
41
What is constrictive pericarditis?
Heavy fibrosis and calcification of the pericardium - becomes a rigid, non-compliant casing for the heart
42
What are the features of constrictive pericarditis?
``` Early filling of heart is normal Later filling is abruptly halted when the heart comes up against the rigid pericardium Venous congestion Oedema Ascites Liver congestion Kussmaul sign JVP rises on inspiration ```
43
What might constrictive pericarditis be confused with on investigation?
Restrictive cardiomyopathy
44
What is the treatment of constrictive pericarditis?
Pericardial resection
45
What is the presentation of hypertrophic cardiomyopathy?
``` Most are asymptomatic Syncope and sudden death Dyspnoea Angina Palpitations ```
46
What is sudden death in patients with hypertrophic cardiomyopathy normally precipitated by?
Competitive sport, usually due to ventricular fibrillation
47
What might be seen on examination of a patient with hypertrophic cardiomyopathy?
May be no findings Notched pulse pattern Irregular pulse pattern if in AF or ectopy Double pulse over apex Thrills and murmurs LVOT murmur will increase with Valsalva manoeuvre and decrease with squatting
48
What are the investigations for hypertrophic cardiomyopathy?
``` ECG Echo CMRI Sudden cardiac death risk assessment ETT FH ```
49
What is the presentation of dilated cardiomyopathy?
``` Progressive, slow onset Fatigue Dyspnoea Orthopnoea Ankle swelling Weight gain due to fluid overload Cough Cardiac failure ```
50
What might be seen on examination of a patient with dilated cardiomyopathy?
``` Poor superficial perfusion Thread pulse Dyspnoea at rest JVP elevated Displaced apex Pulmonary oedema Pleural effusions Ascites Hepatomegaly ```
51
What are the investigations for dilated cardiomyopathy?
``` Repeated ECG CXR for oedema/effusions Brain natriuretic peptide FBC U&Es Echo CMRI Coronary angiogram Biopsy ```
52
What are the investigations for the basic evaluation of restrictive and infiltrative cardiomyopathy?
``` Repeated ECG CXR FBC U&Es Autoantibodies for sclerotic disease Plasma alpha galactosidase A activity for Fabry disease ```
53
What is the presentation of myocarditis?
``` Mild symptoms Chest pain Fever Sweats Chills Dyspnoea ``` Adults may present with heart failure years after an initial index event of myocarditis
54
What is the presentation of viral myocarditis?
History of recent (within 1-2 weeks) flu-like syndrome of fevers, arthralgia and malaise or History of pharyngitis, tonsillitis or upper respiratory tract infection
55
What symptoms of myocarditis might develop due to underlying ventricular arrhythmias or atrioventricular block?
Palpitations Syncope Sudden cardiac death
56
What is the investigation for myocarditis?
``` ECG - usually abnormal Biomarkers - often elevated Echo CMRI Viral DNA PCR Auto-antibodies Strep antibodies Lyme B Burgdorferi HIV ```
57
What is the presentation of pericarditis?
``` Usually 1-2 week duration Chest pain with pleuritic and postural features Relieved by sitting forwards and exacerbated by lying back Fever High temperature Pericardial rub JVP raised Hypotension ```
58
What are the investigations for pericarditis?
ECG Echo Troponin
59
What is the presentation of pericardial effusion?
``` Haemodynamic abnormalities Fatigue Dyspnoea Dizziness Chest pain Pulsus paradoxus JVP raised Pulmonary oedema (rare) ```
60
What are the investigations for pericardial effusion?
Echo | CXR
61
What is the management of hypertrophic cardiomyopathy?
Reduce risk of sudden death with screening Family history - syncope, ventricular tachycardia, exercise hypotension ICD for high risk cases Symptomatic treatments - drugs, surgical resection, septal ablation
62
What general measures can be taken in managing hypertrophic cardiomyopathy?
``` Avoid heavy exercise Avoid dehydration Explore FH and first degree relatives ECG/echo Consider genetic testing ```
63
What specific measures can be taken in managing hypertrophic cardiomyopathy?
Drugs to enhance relaxation - beta blockers, verapamil, disopyramide Anticoagulation if in atrial fibrillation Surgical septal ablation ICD if required/indicated
64
What is the management of dilated cardiomyopathy?
Cause is usually unknown so specific treatment is unavailable Medical treatment can be given for heart failure and arrhythmia if present Thrombi-Embolism prophylaxis Device management with implantable defibrillator or cardiac resynchronisation therapy
65
What general measures can be taken in managing dilated cardiomyopathy?
``` Correct any anaemia Remove any exacerbating drugs e.g. NSAIDs Correct endocrine disturbances Reduce salt and fluid intake Manage weight ```
66
What specific measures can be taken in managing dilated cardiomyopathy?
``` ACEIs ATII blockers Diuretics Beta-blockers Spironolactone Anticoagulants as required SCD risk assessment Cardiac transplant ```
67
What is the prognosis of dilated cardiomyopathy?
Generally poor and often influenced by the cause
68
What is the management of restrictive and infiltrative cardiomyopathy?
``` Limited diuretic use as low filling pressures will cause problems Beta-blockers Limited ACEI use Anticoagulants SCD risk assessment Transplant ```
69
What general measures can be taken in managing myocarditis?
Supportive treatment of heart failure and support for brady/tachy-cardia arrhythmias Immunotherapy if indicated by specific diagnosis Stop possible causative drugs or toxic agent exposure
70
What is the prognosis of myocarditis?
30% full recover 20% mortality at 1 year 56% mortality at 4 years
71
What general measures can be taken in managing pericarditis?
Viral - conservative management Idiopathic - colchicine and limited NSAID use Bacterial - drainage and antibiotics, high death rate, treat aggressively
72
What is the management of pericardial effusion?
Drainage Send for MCS, neoplastic cells, protein and LDH Surgical pericardial window if persistent effusion