Naloxone (Narcan)

Question 1

NALOXONE (NARCAN)

Pharmacology & Actions

Answer 1

• Nalaxone is a narcotic antagonist which competitively binds to opioid receptors in the brain
• Displaces opioid molecules, reversing the effect of opioids on the brain

Question 2

NALOXONE (NARCAN)

Indications

Answer 2

• Reversal of acute opioid toxicity

Question 3

NALOXONE (NARCAN)

Absolute Contraindications

Answer 3

• Naloxone allergy

Question 4

NALOXONE (NARCAN)

Precautions & Side Effects

Answer 4

• May precipitate acute withdrawal symptoms in patients who chronically use opioids
• Agitation, tachycardia, pulmonary edema, nausea, vomiting, and seizures (in neonates)
• Be prepared to restrain the patient as they may become violent with reverse of the narcotic effect
• The duration of some narcotics is longer than Naloxone
• Repeated doses of Naloxone may be required for some opioid toxicities

Question 5

NALOXONE (NARCAN)

Administration

Answer 5

• IV
  
  • Onset: <2 min
  • Peak Effect: <2 min
  • Duration: 20-120 min
• IM/IN
  
  • Onset: 2-10 min
  • Peak Effect: 2-10 min
  • Duration: 20-120 min