Naloxone (Narcan) Flashcards
Narcan - MOA (mechanism of action)
Competitive inhibition of narcotic receptor sites, reverse respiratory depression secondary to depressant drugs, completely inhibits the effects of morphine.
Narcan - Class
Narcan - Indications
Opiate overdose, coma; complete or partial reversal of CNS and respiratory depression induced by opiates; decreased level of consciousness; coma of unknown origin; narcotics agonist for the following: morphine, heroin, hydromorphone (dilaudid), methadone, meperidine (Demerol), paregoric, fentanyl (sublimaze), oxycodone (percodan), codeine, propoxyphene (Darvon); narcotic agonist and antagonist for the following; butorphanol (stadol), pantazocine (Talwin), nalbuphine (Nubain)
Narcan - contraindications
Use with caution in narcotic-dependent patients; use with caution in neonates of narcotic-addicted mothers.
Narcan - adverse reactions
Withdrawal symptoms in the addicted patients. Tachycardia, hypertension, arrhythmias, nausea, vomiting, diaphoresis.
Narcan - drug interactions
Incompatible with bisulfite and alkaline solutions.
Narcan - how supplied
0.4 mg/mL, 1 mg/mL
Narcan - route
Narcan - dosage and administration
Adult: 0.4-2.0 mg IV, minimum recommended dose, 2.0 mg; repeat at 5-minute intervals to a maximum dose of 10 mg (medical control may request higher amount).
Narcan - duration of action
Onset: within 2 minutes. peak effects: variable. Duration : 30-60 minutes.
Narcan - special considerations
Pregnancy safety: category B. Seizures without casual relationships have been reported. May not reverse hypotension. Use caution when administering narcotic addicts (potential violent behavior)