naloxone [Narcan] Flashcards
Classification
Narcan
Narcotic antagonist
INDICATIONs
Narcan
[FR]
- reversal of resp. depression caused by suspected narcotic intoxication
CONTRAINDICATIONs
Narcan
- hypersensitivity
- neonates
Dosage - Adult
Narcan
[EMR]
~~~
1st dose: 0.4 mg IM/IV - q 3mins
2nd dose: 0.4 mg IM/IV
3rd dose: 0.8 mg IM/IV
4th dose : 2 mg IM/IV - (IV preferred)
~~~
cliniCALL - REQUIRED for further doses
Dosage - Pediatric
Narcan
[EMR]
0.1mg/kg - q 3mins
MAX dose 2mg
repeat x 4
Pharmacodynamics
Narcan
- competitively antagonizes opioids bound to receptor in the CNS
opiod receptors mu/kappa/gamma - strongest binding to mu receptor
Pharmacokintetics
Narcan
-IM/IV
onset - 1-3mins
peak - 5-15mins
half-life - 1-3 hrs
duration - 30-45mins
Warnings // Precautions
Narcan
- maybe heat sensitive - may lose potency post 4wks @40C and will require use of higher doses
ADVERSE EFFECTs
Narcan
- SUDDEN reversal => combativeness
- S&S of withdrawl
- Hypotension, hypertension
- Nausea, vomiting, sweating,
- Tachycardia
Types of Rx narcotics
Narcan
Demerol, Heroin, Codeine, oxymorphone (Numorphan), hypdromorphone (Dilaudid), diphenoxylate (Lomotil), propoxyphene (Darvon) and pentazocine (Talwin)