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Uworld NAPLEX > NAPLEX: Infectious Disease I (Bacterial) > Flashcards

NAPLEX: Infectious Disease I (Bacterial) Flashcards

(75 cards)

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1
Q

Gram positive cocci in clusters indicates _______ whereas pairs indicates ________ or _____________.

A

clusters: staph
Pairs: strep, enterococcus

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2
Q

SPACE bugs

A

Serratia
Pseudomonas
Acinetobacter
Citrobacter
Enterobacter

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3
Q

HNPEK bugs

A

Haemophilus, Neisseria, Proteus, E. coli, Klebsiella

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4
Q

Selection pressure definition

A

resistance occurs when ABX kill off susceptible bacteria and leave the resistance strains that multiply more

Ex. VRE

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5
Q

Zosyn covers what additional bugs on top of aminopenicillins with a b lactamase inhibitor

A

pseudomonas
SPACE bugs

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6
Q

Which abx has BBW for C. Diff?

A

Clindamycin

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7
Q

The addition of a beta-lactamase inhibitor adds activity for what?

A

Klebsiella (Aminopenicillins only cover HNPE- no K)
MSSA
B frag

(Aminopenicillins already cover strep, enterococci, mouth flora, and HNPE (no k)

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8
Q

Which is IV, PO, and IM
Penicillin VK
Bicillin L-A
Penicillin G Aqueous

A

PO: Penicillin VK
IM: Bicillin L-A
IV: Penicillin G Aqueous

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9
Q

Which abx class has risk for seizures with accumulation

A

(All beta lactams)
Penicillins
Cephalosporines
Carbapenems

Quinolones- DO NOT USE W SEIZURE DISORDER

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10
Q

Which abx class has a risk for hemolytic anemia

A

Penicillins
Cephalosporines
Bactrim
Nitrofurantoin

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11
Q

IV amp and unasyn have to be diluted in

A

NS

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12
Q

Which generation?
Cefazolin
Cefotetan
Cefepime
Cefuroxime

A

Cefazolin 1
Cefotetan 2
Cefepime 4
Cefuroxime 2

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13
Q

Which generation?
Cephalexin
Ceftaroline
ceftazidime

A

Cephalexin 1
Ceftaroline 5
ceftazidime 3

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14
Q

all cephalosporines cover HNPEK except for which generation

A

1

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15
Q

Which generation?
ceftriaxone
cefotaxime
cefdinir
cefoxitin

A

ceftriaxone 3
cefotaxime 3
cefdinir 3
cefoxitin 2

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16
Q

Which abx class should not be used in neonates due to risk of kernicterus

A

cephalosporines

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17
Q

Which TWO ABX can cause a disulfram reaction with alcohol

A

Cefotetan
Metronidazole

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18
Q

Ceftriaxone + ___________ in the same line can cause precipitation

A

calcium

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19
Q

Ertapenem doesn’t cover against _______ like the other carbapenems

A

PEA:

Pseudomonas
Enterococcus
Acinetobacter

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20
Q

Aztreonam indication

A

Pseudomonas or Gram -
Plus B lactam allergy

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21
Q

Goal trough for aminoglycosides (treatment)

A

<2

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22
Q

Traditional IV dosing for aminoglycosides (mg/kg)

A

1-2.5mg/kg/dose

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23
Q

Extended IV dosing interval for aminoglycosides (mg/kg)

A

7mg/kg/dose

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24
Q

When is a level drawn for extended dosing aminoglycosides

A

random level after the first dose (6-14 hours after)

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25
What does the Hartford diagram demonstrate
Used to plot the patient's level on the Ainoglycoside curve to determine interval
26
If the gent level falls on the line of the Hartford nomogram, use (higher/lower) interval
Higher (more spaced out)
27
Which ABX MOA? Inhibit DNA topoisomerase IV and DNA gyrase (topo ii)
Quinolones
28
Tendon rupture SE- which ABX
quinolones
28
Quinolones: Which is not a respiratory quinolone? Which 2 have activity against pseudomonas? Which is not for treatment of UTI?
Which is not a respiratory quinolone? Cipro Which 2 have activity against pseudomonas? Cipro, levo Which is not for treatment of UTI? Moxi
29
Peripheral neuropathy SE- Which ABX
Quinolones
30
ABX that cause glycemic changes
Quinolones
31
QT Prolonging ABX
Quinolones (highest with Moxi) Macrolides
32
ABX that cause psychiatric disturbances
Quinolones
33
ABX that have interactions with antacids
Quinolones Tetracyclines Cefuroxime, cefpodoxime
34
MOA: bind 50S ribosomal subunit and inh RNA dependent protein synthesis
Macrolides
35
Which ABX has a SE of Hepatotoxicity
Macrolides
36
MOA: Bind to the 30S ribosome. Which ABX?
tetracycline
37
Which abx have a risk for DILE
minocycline
38
Doxycycline IV to PO
1:1
39
Which ABX should not be used with a G6PD deficiency
Bactrim
39
MOA: inhibit the folic acid pathway
sulfonamides
40
Which Abx have a risk of SJS
Bactrim
41
Bactrim increases which electrolyte
K
42
Which abx has a risk of crystaluria
Bactrim
43
The SMX to TMP dosing ratio is ____:____ and dosed off the _____ component
5:1 TMP
43
Which ABX has a increased risk INR when used with Warfarin
Bactrim
44
At what crcl should vanco be dosed as q24h?
20-49
45
Which ABX cannot be administered concurrently with UFH Which ABX requires a washout of 5 days before using UFH
1. Televancin 2. Oritavancin
45
MOA: Bind D-ala-D-ala
Vanco AND Lipoglycopeptides (-vancin)
46
Which abx causes incr CPK
Daptomycin
47
Which drug requires caution with serotonin drugs
Linezolid
48
MOA Binds 50S subunit
Linezolid Clindamycin
49
Which abx has a BBW of death and is not used often
Tigecycline
50
Which abx are used for MDR gram negative pathogens and have a neprotoxicity risk
Polymixin V
51
Which drug cannot be used with a + D test? What is the appearance of the disks to indicate + D test?
Clinda Flattened zone in the middle
52
Metronidazole is CI in ____ trimester of pregnancy
1
53
At what crcl can Nitrofurantoin not be used?
<60
54
List the drugs that cover pseudomonas
(7) Zosyn Cefepime Ceftazidime Aztrenam Cirpo Levo TIC Tobramycin Imipenem + carbapenem
55
Which abx cover MRSA
(7) Vanco Dapto Linezolid Doxycycline Ceftaroline Bactrim Clindamycin
56
Which abx cover atypicals?
(3) Azithro Doxyxycline Quinolones
57
Which ABX cover HNPEK bugs
ABBCCQ Aminoglycosides Beta lactams Bactrim Cephalosporines (not first gen) Carbapenems Quinolones
58
First line CRE
Avycaz
58
Which abx cover SPACE bugs
(4) Zosyn Cefepime Carbapenems Aminoglycosides
59
Which Abx can you not refrigerate
Cefdinir Bactrim IV Metronidazole IV Moxiflox IV
59
Which 2 cephalosporines should be seperated from antacids
Cefuroxime Cefpodoxime
59
Which antibiotic leaves a metallic taste in your mouth
metronidazole
60
How long should you not drink alcohol after taking metronidazole 3 days
3 days
61
There is Bactrim and Bactrim DS- what are the dosages of each
Bactrim: S 400/ T 80 Bactrim DS (double strength): 800/160
62
Which covers MRSA? Ortavancin Tedizolid Polymixin
Ortavancin
63
Which quinolone covers MRSA?
Delafloxacin
64
Which are oral? Cefuroxime Cefpodoxime Cefotaxime Cefotetan
Cefuroxime Cefpodoxime Cefotaxime (ALSO IV)
64
Which of the following interfere with coagulation lab assays? Bactrim Daptomycin Linezolid Ortavancin Televancin
Daptomycin Ortavancin Televancin
65
Which are side effects of gentamycin? Cardiotoxicity Neurotoxicity Pulmonary toxicity Nephrotoxicity Ototoxicity
Neurotox Nephrotox Ototox
66
Which abx requires a negative pregnancy test before use
Televancin
67
Which antibiotic IV has to be kept at room temperature Clinda Metronidazole Ampicillin Cipro Vanco
Metronidazole

Uworld NAPLEX (13 decks)

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