Nassa and MAOI

Question 1

what Do NaSSa’s do?

Answer 1

• block presynaptic alpha 2 adrenoceptors

- increasing noradrenergic and serotonergic neurotransmission

Question 2

what is an example of a NaSSa? (1)

what are the Side effects of NaSSas?

Answer 2

• mirtazapine
• weight gain, sedation (although this can be good)
• safer in overdose
• fewer SE/s than traditional antidepressants
• more sedating at lower doses

Question 3

What is the function of MAOIs?

Answer 3

• inhibit enzymatic breakdown of noradrenaline, serotonin, dopamine and tyramine

Question 4

what can you not do on MAOIs?

Answer 4

• eat foods rich in tyramine (marmite, pickled herring, red wine)
• causes hypertension
• these are last resort drugs, not often used