SNRIs

Question 1

what do SNRIs do?

Answer 1

• inhibit serotonin, noradrenaline (and dopamine?) reuptake

Question 2

name two SNRIs?

Answer 2

• venlafaxine

- duloxetine

Question 3

what are the side effects of SNRIs?

Answer 3

• Raised BP (at higher doses)
• sexual dysfunction
• toxic in overdose
• non-sedating

Question 4

what is the problem with venlafaxine? (2)

Answer 4

• SSRI action only up to 150mg/day
• high risk of withdrawal
• may need to inform DVLA as it can affect performances of skilled tasks (e.g. driving)

Question 5

what is the withdrawal like in venlafaxine?

Answer 5

• GI disturbance
• headache
• anxiety, dizziness
• paraesthesia
• sleep disturbance
• tremor