NB (065) Practical of Neuropathology

Question 1

Answer 1

Question 2

Answer 2

Question 3

Which cell is responsible for repair of NS injury?

Answer 3

Question 4

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Question 5

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Question 6

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Question 7

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Question 8

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Question 9

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Question 10

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Question 11

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Question 12

Mention the two sets of monocyte / macrophage cells in CNS

Answer 12

• Parenchymal (resident) microglial cells

• Blood-borne monocytes

Question 13

Define Gliosis

Answer 13

• Gliosis: non specific reaction to any brain injury, e.g. e.g., ischemia, trauma, neurodegenerative diseases, demyelinating diseases, …)

Question 14

Define Microglia activation

Answer 14

• Microglia activation is non specific reaction to any brain injury, e.g. e.g., ischemia, trauma, neurodegenerative diseases, demyelinating diseases, …)

Question 15

MS affects the central nervous system (CNS) Which part of the CNS is affected?

A. Nerve cells (neurons)

B. Myelin

C. Plaques

D. Vertebrae

Answer 15

Question 16

Although the exact cause of MS is not yet known, which factor may play a role?

A. Environment

B. Viruses

C. Family history

D. All of the above

Answer 16

D. All of the above

Question 17

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Question 18

what do you see

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Question 19

What do you see

Answer 19

Question 20

identify the type of MS plaque and tell why

Answer 20

Question 21

identify the type of MS plaque and tell why

Answer 21

Question 22

identify the type of MS plaque and tell why

Answer 22

Question 23

identify the type of MS plaque, identify the stain and tell why

Answer 23

Question 24

Which of the following genetic phenomena are associated with Huntington’s disease?

A. Trinucleotide repeats

B. Autosomal Dominant Inheritance

C. CAG nucleotide expansion

D. All of the above

Answer 24

Question 25

Individuals with Huntington’s Disease are those who have how many CAG repeats on chromosome 4? A. 20-31 B. 5-20 C. 31-33 D. 36-120 E. 1-5

Answer 25

Question 26

What type of mutation is Huntington’s disease? A. Sex-linked dominant B. Autosomal dominant C. Autosomal recessive D. Sex-linked recessive

Answer 26

Question 27

Huntington’s disease results in the loss of ……. Function A. GABAergic B. Cholinergic C. Dopamine D. None of the above

Answer 27

Question 28

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Question 29

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Question 30

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Question 31

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Question 32

The peak age of onset for Parkinson’s disease is in the following decade A. Third B. Fourth C. Fifth D. Sixth

Answer 32

Question 33

The part of the brain most affected in Parkinson’s disease is A. Corpus striatum B. Putamen C. Substantia nigra D. Thalamus

Answer 33

Question 34

Parkinson disease is marked by a shortage of which chemical in the brain? A. Serotonin B. GABA C. Dopamine D. Norepinephrine

Answer 34

Question 35

Eosinophilic cytoplasmic inclusions seen in the brain cells of a patient with Parkinson’s disease are A. Golgi bodies B. Lewy bodies C. Paschen bodies D. All of the above

Answer 35

Question 36

What is the nature of Lewy bodies?

Answer 36

➢ Lewy body is an aggregate of ⍺ - synuclein

Question 37

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Question 38

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Question 39

True or false α- synuclein and Parkin genes are linked to Parkinson's disease

Answer 39

Question 40

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Question 41

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Question 42

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