NB histology Flashcards

(40 cards)

1
Q

Where are nissl bodies found in a neuron cell body?

A

soma and dendrites

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2
Q

What is the function of nissl bodies?

A

Production of cytoskeletal proteins, proteins for transport and neurotransmitters

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3
Q

Where are golgi apparatus found in the neuron cell body?

A

Only in the cell body

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4
Q

Where is the mitochondria found and where is abundant?

A

Throughout the cell body but abundant in the axon terminal.

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5
Q

Where are centrioles found in the neuron?

A

neurons don’t have centroiles since they can’t divide

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6
Q

What is a neurons nuclei and cytoplasm like?

A

nuclei: large roumd with dispersed chromatin and prominent nucleoli reflecting a high level of protein synthesis
cytoplasm : Abundant basophilic (extensve ribosomal RNA)

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7
Q

what are the functions of microtubules?

A

Tracks along which material is transported to and from the cell body
function: Fast axonal transport

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8
Q

What are the functions of neurofilaments ?

A

intermediate filaments, structural support
function: tensile scaffold

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9
Q

What are the organelles in the synaptic knob?

A

excess of mitochondria, only smooth er, synaptic vesicle containing neurotransmitter

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10
Q

which cells in the PNS are myelinated?

A

large diameter fibers wrapped by concentric layers of the schwann cell plasma membrane

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11
Q

Which PNS cells are non meylinated?

A

small diameter axons those autonomic nervous sytem and small pain fibers enveloped by cytoplasm of schwann cells

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12
Q

How many axons cn one oligodemdrocyte myelinate?

A

50 axons

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13
Q

What is an automatic ganglion?

A

Cell bodies of autonomic nerves

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14
Q

What are dorsal root ganglia ?

A

Cell bodies of sensory (afferent) neurons

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15
Q

What are the type of neurons found in the posterior horn cells?

A

sensory neurons

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16
Q

what are the types of neurons found in the anterior horn cells?

A

motor neurons

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17
Q

what are the types of neurons found?

A

sensory, motor and interneurons

18
Q

What are the folds in the cerebullum called?

19
Q

What are the components of the grey matter?

A

Cell bodies, unmeylinated nerve fibers, neuroglia and blood vessels

20
Q

What are the components of the white matter?

A

Myelinated nerve fibers, neuroglia and blood vessels

21
Q

What is the central canal ?

A

Found of in the center of grey matter, lined by ependymal cells and contains csf

22
Q

What is neuropil?

A

Dense network formed by the processes of both neurons and glial cells, which fills all the spaces of CNS

23
Q

What is the difference between the dorsal and ventral horns under spinal cord H&E stain?

A

Dorsal horn: much less prominent and contain the cell bodies of small second order sensory neurones
Ventral horns: most promenint and containing celll bodies of the large lower moor neurones.

24
Q

what are the glial cells foind in the CNS?

A

Ependymal cells
Astrocytes
Microglial cells
oligondendrocytes

25
What are the layers of the nerve bundle from outside to inside?
(EPE pen) Epineurium Perineurim Endoneurium
26
What is are the layers of the cerebellar cortec inside out?
Inner granular layer purkinje cells Outter molecular layer
27
What is the structure of the blood brain barrier?
continuous endothelial cells with tight junctions Thick continuous basement membrane End feet of strocytes firmly applied on cappilaries
28
What is the function of the blood brain barrier?
Prevent harmful material from entering the nerve cells while allowing nutrients to pass by faciliated diffusiona and active transport
29
What are the six layersof the cerbral cortex?
1. molecular layer 2. external granular layer 3. external pyramidal cell layer 4. Internal granular layer 5. Ganflionic layer (internal pyramidal cells) 6. Multiform (polymorphic) cell layer
30
What gives the fried egged look of the oligondendrocytes?
Delayed fixation
31
What are the neurons found in the cerebral cortex?
1. pyramidal cell 2.Stellate(granule) cells 3. Fusiform cells 4.Horizontal cells of cajal 5.Cells of martinotti
32
what are the diffferent types of ganglion cells?
Alpha and beta (Alpha are wider and have more dendritic connections than beta)
33
What is GFAP?
Glial fibrillary acidic protein Used as a marker for astrocytic cell
34
What are the different type of synapses?
Axosomatic synapse Axodendritic synapse Axoaxonic synapse
35
What are special stains used to stain white matter and what color is given?
luxolfast blue: Myelin>blue Osmic acid: Myelin> Black
36
What are special IHC stains used to stain white matter?
Myelin basic protein: myelin> brown neurofilament: axon> brown
37
What IHC stain is ued to stain grey matter?
Synaptophysin: synapse>brown
38
What IHC stain is used to stain glial cells?
Glial fibrillary acid protein: brown
39
What special stain can be used to stain the whole neuron?
Golgi stain method: black
40
What special stain is used to stain grey matter?
NIssl stain method: cell body> blue