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Anesthesia Pharmacology > ND-NMBA Drugs > Flashcards

ND-NMBA Drugs Flashcards

1
Q

Rocuronium Class

A

Steroidal nondepolarizing muscle blocking agent

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2
Q

Rocuronium Use

A

Standard and rapid sequence induction

Maintenance of neuromuscular blockade

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3
Q

Rocuronium Dosing

A

Induction dosing: 0.6 – 1.2 mg/kg

RSI dose: 1.2 mg/kg

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4
Q

Rocuronium Onset and DOA

A

Onset: 3 minutes
DOA: 60 minutes

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5
Q

Rocuronium Metabolism

A

Hepatic and renal

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6
Q

Rocuronium Excretion

A

Eliminated by the liver (20%) and kidneys (80%)

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7
Q

Rocuronium Reversal

A

May reverse with sugammadex

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8
Q

Vecuronium Class

A

Steroidal nondepolarizing muscle blocking agent

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9
Q

Vecuronium Use

A

Standard induction and maintenance of neuromuscular blockade

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10
Q

Vecuronium Dosing

A

Induction dosing: 0.1 mg/kg

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11
Q

Vecuronium Onset and DOA

A

Onset: 4 minutes
DOA: 60 minutes

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12
Q

Vecuronium Metabolism

A

Hepatic and renal

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13
Q

Vecuronium Excretion

A

Eliminated by the liver (50%) and kidneys (50%)

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14
Q

Vecuronium Reversal and Considerations

A

May reverse with sugammadex

Must be reconstituted

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15
Q

Cisatracurium Class

A

Benzylisoquinolinium nondepolarizing muscle blocking agent

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16
Q

Cisatracurium Use

A

Standard induction and maintenance of neuromuscular blockade

17
Q

Cisatracurium Dose

A

Induction dosing: 0.1 mg/kg

18
Q

Cisatracurium Onset and DOA

A

Onset: 4 minutes
DOA: 60 minutes

19
Q

Cisatracurium Metabolism

A

Hofmann elimination (75%) and nonspecific esterase hydrolysis (25%)

20
Q

Cisatracurium Active Metabolite

A

Laudanosine metabolite, which is a CNS stimulant

20% less laudanosine is produced when compared to atracurium

21
Q

Cisatracurium Excretion

A

Eliminated by the kidneys

22
Q

Cisatracurium Special Considerations

A

Hofmann elimination is a temperature- and pH-dependent break- down of the drug molecule.

Anesthesia Pharmacology (23 decks)

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