Neisseriacaea

Question 0

Are neisseriacaea oxidase negative or positive?

Answer 0

Oxidase positive

Question 1

Neisseriacaea mode for motility?

Answer 1

Imotile. Non flagellated

Question 2

Neisseriacaea response to oxygen?

Answer 2

Strict aerobes

Question 3

What is the main pathogen in Neisseriacaea?

Answer 3

Neisseria

Question 4

What is the morphology is neisseria?

Answer 4

Dipplococci

Question 5

What is pyogenic?

Answer 5

Pus forming

Question 6

Where to neisseria reside in the body?

Answer 6

In The WBC.

Resistant to phagocytosis

Question 7

What is the major virulence factor of neisseria gonorrhaea?

Answer 7

Pilli. Pilin adhesion to the epithelial cells allows uptake by endocytosis.

Non capsulated

Question 8

In gonorrhoea, what acts on the macrophages to release TNF?

Answer 8

Endotoxins (lipopolysaccharides) that are released by neisseria gonorrhaea

Question 9

What causes the cell damage in the urethra in gonorrhoea?

Answer 9

Inflammation caused by the inflammatory cytokine TNF which is released by macrophages.

Question 10

Why is it a common problem that N.G can go on to cause pelvic inflammatory disease in women?

Answer 10

Because it is often asymptomatic in women. So treatment is not seeked.

Question 11

What are some secondary diseases that can be caused if N.G becomes systemic?

Answer 11

PID, meningitis, endocarditis, arthritis, dermatitis

Question 12

Which three bacteria can cause meningitis?

Answer 12

Neisseria meningitidis

Meningococcal septicaemia

Meningococcal meningitis

Question 13

What causes the initial bacteremia in meningitis from N.meningitidis?

Answer 13

Invasion of the bloodstream from the nasopharynx where it is commensal in 10-20% of pop.

Question 14

What is the progression of meningitis caused by N.Meningitidis?

Answer 14

Commensal
Bacteremia
Septicaemia 
Cross BBB 
CNS infection > meningitis

Question 15

What is the key virulence factor of N.meningitidis?

Answer 15

LPS.

Shed as membrane blebs- stimulating cytokine release from host cells causing inflammation.

Question 16

What is ‘shock’?

Answer 16

Catastrophic drop in blood pressure due to internal bleeding.

Hard to reverse

Question 17

Which form of meningitis causes gangrene, organ failure and shock?

Answer 17

Meningococcal septicaemia

Question 18

What are the three meninges of the brain

Answer 18

Arachnoid, dura mater, Pia mater

Question 19

Why is meningitis difficult to diagnose in infants and adolescents?

Answer 19

Common symptoms

Headache, fever, photophobia, malaise

Question 20

What is the treTment for meningitis?

Answer 20

Intravenous benzyl penicillin. [best at passing BBB]

Treatment must be early to be effective.

Question 21

How is meningitis serotyped?

Answer 21

Classified by composition of capsular LPS.

A B C & Y

Question 22

What is the most common worldwide serotype of meningitis?

Answer 22

A

Question 23

Which meningitis serotyped are most common I’m Europe and USA?

Answer 23

B & C

Question 24

How does a conjugated vaccine work?

Answer 24

Stimulates T cells, therefore promotes a long term immunity.