Neonatal and newborn conditions Flashcards
(179 cards)
1
Q
Is neonatal jaundice common? Esp in who?
A
Yes mild is common esp in pre-term
2
Q
Which time scales of neonatal jaundice need investigation?
A
First 24hr or lasting beyond 2w
3
Q
What builds up in neonatal jaundice? What are the two types?
A
Bilirubin Unconjugated Conjugated
4
Q
What two mechanisms cause unconjugated hyperbilirubinaemia?
A
Excessive haemolysis or impaired conjugation
5
Q
What are the 8 causes of unconjugated hyperbilirubinaemia?
A
Prematurity (immature liver enzymes)
- Rh incompatible (haemolytic disease of the newborn (see notes at bottom). Coomb’s test positive.)
- ABO incompatible (usually milder than Rh)
- Infection (bacterial)
- Bruising (traumatic delivery)
- Hypothyroid (?pituitary disease)
- Breast milk jaundice
- Physiological
6
Q
What is physiological unconj hyperbil. due to? what might it need treatment with?
A
- low liver enzyme activity (liver immaturity, particularly in pre-term) or breakdown of foetal haemoglobin. Occasionally needs phototherapy.
7
Q
What is breast milk jaundice?
A
otherwise well baby who is breast-fed develops jaundice day 4-7 until week/month 3. Normal coloured stool and urine. Inhibition of liver conjugation enzymes by breast milk. Diagnosis of exclusion- measure split bilirubin to exclude conjugated hyperbilirubinaemia.
8
Q
What test would be positive in haemolytic disease of the newborn?
A
Coomb’s test (rhesus)
9
Q
Why does conjugated hyperbil. occur?
A
Obstruction of drainage of bile ducts
10
Q
What are the 4 reasons conj, hyperbil. occurs?
A
Hepatitis CF Choledocal cyst Biliary atresia
11
Q
What are the different types of hepatitis that could cause conj. hyperbil/?
A
A, B, C, CMV Inborn error of metabolism e.g. galactosaemia
12
Q
Is biliary atresia common?
A
No 1 in 10,000
13
Q
What is biliary atresia? What are the signs? What would an investigation show? What is the management and what happens if untreated?
A
o Persistent jaundice with rising conjugated fraction over weeks. (>20% after 2 weeks = refer, any jaundice persisting after 2 weeks should have both bilirubins checked.) o Pale, chalky stools o Due to absence of intra/extrahepatic bile ducts. o Undiagnosed- liver failure and may die without transplant. o Urgent referral to paediatric hepatologists for assessment, diagnostic isotope scan and surgical correction.
14
Q
What is the normal breakdown of bilirubin?
A
RBC breakdown (haem)→ biliverdin→ unconjugated (lipid soluble, can cross BBB) bilirubin → conjugation occurs in liver, conjugated bilirubin is water soluble → enters gut via bile → gut enzymes break it down into urobilinogen → 80% excreted in faeces as stercobilinogen, 2% in urine as urobilin and 18% enter enterohepatic circulation.
15
Q
Important things to ask in the history of neonatal jaundice?
A
• Age developed (within 24h investigate) • Risk factors for infection • Fhx e.g. CF, spherocytosis • How is baby? Active, alert, feeding well? Lethargic and must be woken for feeds (sig. jaundice) • Breast feeding?
16
Q
Examination findings of neonatal jaundice?
A
• Extent (spreads head down) • Features of congenital viral infection e.g. petechiae, anaemia, hepatosplenomegaly • Dehydrated? • Pale stool • Baby well in general?
17
Q
Investigations for neonatal jaundice? What is the justification for each?
A
• Bloods: o FBC (thrombocytopenia = viral infection or IUGR, anaemia = haemolytic disease, neutropenia or neutrophilia in infxn) o CRP (?) o Group and Coombs (ABO and Rh) o TFT o LFT (high ALT suggests hepatitis) o Coag o TORCH screen (for Hep B, CMV) • Urine metabolic screen (inborn errors of metabolism) • Liver USS • Liver isotope scan (r/o biliary atresia in persistent conjugated hyperbilirubinaemia) • ?Urine and CSF infection screen
18
Q
Management options for neonatal jaundice (5)
A
Identify cause and severity Phototherapy Exchange transfusions Refer to hepatology if biliary atresia Vitamin K supplement depending on coag screen results
19
Q
What does phototherapy do in neonatal jaundice?
A
Blue light 450nm wavelength converts unconjugated bilirubin to biliverdin (an isomer that can be excreted by the kidneys. In rhesus or ABO incompatibility, if bilirubin levels rise significantly despite phototherapy, may need exchange transfusion.)
20
Q
When are exchange transfusions needed in neonatal jaundice and why?
A
Severe neonatal jaundice to prevent kernicterus
21
Q
What is kernicterus?
A
When free bilirubin crosses BBB, deposited in basal ganglia- acute encephalopathy with irritability, high pitched cry or coma. Can lead to deafness and athetiod cerebral palsy.
22
Q
What is haemolytic disease of the newborn?
A
If ABO or Rh incompatible, Maternal IgG crosses placenta, reacts with foetal RBC antigens.
23
Q
What happens with haemolytic disease of the newborn in utero?
A
Foetal anaemia can = hydrops (severe oedema)
24
Q
What is the in-utero management of haemolytic disease of the newborn?
A
Could have intra-uterine blood transfusion if severe Should be delivered before severe haemolysis
25
In babies with haemolytic disease of the newborn, what happens after birth?
Anaemic and quickly become severely jaundiced
26
Treatment for haemolytic disease of the newborn after birth?
o ‘Wash out’ maternal antibodies and bilirubin with exchange transfusions and phototherapy. o Can give IV Ig to block antibody sites.
27
How long might haemolytic disease of the newborn persist?
Several weeks (might still have some Ig around for a bit)
28
Not obvious reasons a paediatrician should be present at a birth
Meconium stained liquor vacuum, mid/high forceps delivery prolonged ROM
29
The infants condition after birth is described using the ____ score
APGAR
30
what do the bits of apgar stand for?
appearance pulse grimace (reflex irritability- suction pharynx to test) activity (muscle tone) RR
31
What is max apgar score?
10
32
What is a normal APGAR at one minute
7-10
33
At one minute an apgar score of what indicates a moderately depressed baby
4-6
34
At one minute apgar of 0-3 indicates what?
Severely depressed baby
35
Babies who require active resuscitation can be divided into what two groups?
Primary apnoea and secondary apnoea
36
What is primary apnoea
Blue colour due to failure to establish spontaneous respiration, but cardio system intact with good circulation Apgar at 1min 4-6
37
What is secondary apnoea?
White colour at birth as failure of circulation as well as respiration. Will die without vigorous resus. Slow or absent HR. Apgar at 1min 0-3
38
What normally happens to amniotic fluid during delivery?
Expelled from lungs by contractions
39
How can you encourage breathing at birth?
Dry with warm towel Gently suck out oropharynx Give to mother to put on breast or cuddle
40
Apnoiec within the first _____ requires basic resus
Minute
41
Will blue or white babies start to gasp even if nothing is done?
Blue
42
Do blue babies require lung inflation, cardiac support or both?
Lung inflation
43
Do white babies require lung inflation, cardiac support or both?
Both
44
How does tissue hypoxia lead to tissue acidosis?
Lactic acid and CO2
45
What is the accepted clinical definition of asphyxia?
N/A doesn't exist
46
What are some used definitions of asphyxia?
Cord blood gas \<7.05 0-5 APGAR at 10mins \>10m to establish spont respiration Hypoxic-ischaemic encephalopathy
47
What is hypoxic ischaemic encephalopathy?
Abnormal neuro signs including convulsions lasting \>2 days
48
How do you manage birth asphyxia?
Rapid and effective resus at birth Avoid cerebral oedema and treat convulsions
49
Prognosis of asphyxiated infants?
25% severely asphyxiated full term infants die or are severely handicapped Therapeutic cooling can improve neuro outcomes in survivors
50
What are the 3 categories of HIE?
Mild, mod, severe
51
What is mild HIE like?
Increased muscle tone, brisk tendon reflexes, transient behavioural abnorms like poor feeding or excessive crying. Typically resolves in 24h
52
What is moderate HIE like?
Lethargic, hypotonia, diminished reflexes. Grasping/moro/sucking reflexes may be absent. Periods of apnoea. Seizures in first 24h after birth. Full recovery within 1-2w possible
53
What is severe HIE like?
Seizures delayed and severe, may be initially resistant to conventional treatment. Usually generalised, freq may increase in the first 24-48h after onset (reperfusion injury).
54
What is a cephalohaematoma
Haemorrhage of blood between skull and periosteum
55
Why does cephalohaematoma occur in neonate
rupture of blood vessels crossing the periosteum usually due to prolonged second stage of labour or forceps delivery (not ventous)
56
Does cephalohaematoma pose a risk to brain cells?
No, considered a minor injury
57
How does cephalohaematoma present?
soft, fluctuant swelling on head appearing soon after birth
58
Do cephalohaematomas extend beyond the edges of the bone or cross suture lines?
No
59
Severe cephalohaematoma can cause what 3 things?
Jaundice, anaemia, hypotension
60
What can complications of cephalohaematoma be?
It may indicate linear skull fracture, or be at risk of infection (osteomyelitis, meningitis)
61
How long does it take for cephalohaematoma to resolve
Weeks. It calcifies in that time and appears as a depressed fracture
62
cephalohaematoma should be distinguished from \_\_\_?
sugaleal haemorrhage- between scalp and skull bone (above periosteum)- this is more extensive and prone to complications (anaemia and bruising)
63
Management cephalohaematoma
Mainly observational IF NEURO Sx- Skull xray or CT IF JAUNDICE- phototherapy IF ANAEMIA- blood transfusion (rare) consider bleeding disorder (unlikely)
64
Do you need to take bloods for cephalohaematoma?
Not usually
65
Should you aspirate a cephalohaematoma?
No risk of infection and abscess formation
66
Prematurity is defined as what gestation?
\<37w
67
'extremely premature' is ? gestation
\<28w
68
From what premature age can babies survive
23w but mortality 60-70% and only 25% disability free
69
Prognosis is excellent beyond what premature gestation?
30-32w
70
Risk factors for prematurity?
Young maternal age Multiple pregnancy Infxn Maternal 'illness' (HTN, cervical incompetence, APN, smoking, alcohol, infection)
71
3 big risks of prematurity?
Hypothermia Hypoglycaemia Feeding difficulties
72
Where are premature babies cared for?
SCBU or NICU
73
What is the benefit of incubators?
Warmth and humidity
74
When does the suck-swallow pattern develop?
34w gestation
75
What respiratory conditions are associated with prematurity?
RDS Pneumothorax Pulmonary haemorrhage Bronchopulmonary dysplasia Apnoea Hypoxia-ischaemia
76
What is the most common cause of resp distress in a premature baby?
RDS
77
What is RDS?
Insufficient surfactant. Neonatal lungs non-compliant (stiff)- leads to hypoxia and acidosis
78
When does surfactant normally develop?
35-36w although stress of labour normally stimulates it so RDS can be self limiting to 5-7 days.
79
What can RDS lead to?
hypoxia and acidosis, if severe can cause PPHN (persistent pulmonary hypertension of the newborn)
80
What predisposes a baby to RDS?
Premature Hypoxia, shock, acidosis, asphyxia Second twin APH Diabetic mother
81
What protects a baby against RDS?
Prolonged IU stress as they have endogenous corticosteroid release e.g. in IUGR. Maternal steroids pre-labour
82
How does RDS present?
Resp distress from 6 hours Tachypnoea, recessions, cyanosis, grunting
83
What is the course of RDS?
worsens over 2-3 days then improves over 1-2 weeks
84
What does a CXR of RDS show?
Ground glass appearance Air bronchograms
85
Management of RDS?
Surfactant replacement via ETT (porcine) Ventilatory support (O2, CPAP/nasal prongs/PPV) ABx if susp infection Minimal handling
86
Complications RDS
Pneumothorax, IV haemorrhage, 20% develop bronchopulmonary dysplasia (late)
87
When should maternal steroids be given to prevent RDS?
48h before delivery (or ASAP if that time has passed already)
88
How does pneumothorax present in premature neonate and what is the cause?
Mostly asymptomatic, can be idiopathic or sometimes due to ventilation
89
Why does pulmonary haemorrhage happen in premature neonate?
elevated pulmonary capillary pressure from an acute LV failure or lung injury (e.g. RDS, pneumonia)
90
How does pulmonary haemorrhage present in premature neonate ?
Frothy pink sputum and acutely unwell
91
What is bronchopulmonary dysplasia?
Chronic lung damage due to disrupted development in premature neonate.
92
What radiological changes are seen in bronchopulmonary dysplasia?
Honeycomb lung (hyperexpanded and diffuse fibrosis)
93
bronchopulmonary dysplasia usually follows \_\_\_?
Severe RDS
94
bronchopulmonary dysplasia may require what treatment?
LTOT for months/years
95
How will bronchopulmonary dysplasia present?
Oxygen requirement on day 28 of life or 36w gestation
96
apnoea definition
not breathing for \>20s ± bradycardia and cyanosis
97
What are the causes of apnoea
Many chemoreceptor/resp centre immaturity (poorly developed in neonates) airway obs asipration infection hypoglycaemia PDA
98
How do you treat apnoea
Treat underlying cause if poss Stimulate Oropharyngeal suction Bag mask (neonatal resus essentially)
99
Is it ok to have fluctuating O2 levels in premature babies?
Not too much- can lead to retinopathy of prematurity
100
Hypoxia-ischaemia after birth can result from what three things? (prematurity)
Severe shock Inadequate breathing Severe aneamia
101
What is the effect of hypoxia ischaemia?(prematurity)
It can effect all organs e.g. NEC, tubular necrosis, HIE, heart failure, RDS, PPHN, metabolic acidosis, hypoglycaemia...
102
What is the most important factor/body system in long term prognosis of prem baby?
Neuro
103
What is intraventricular haemorrhage? (prematurity)
Haemorrhage on floor of lateral ventricle and ruptures into the ventricle. Can cause obstructive venous infarct of the surrounding white matter and risks hemiplegic cerebral palsy.
104
Is IVH always symptomatic? (prematurity)
No
105
How is IVH diagnosed? (prematurity)
USS
106
15% babies get what after IVH? How is this managed? (prematurity)
Post haemorrhagic hydrocephalus which may require a ventriculo peritoneal shunt
107
What is the commonest cause of cerebral palsy in surviving premature infants?
Periventricular leucomalacia
108
What is periventricular leucomalacia? (prematurity)
ischaemic damage to periventricular white matter
109
What is more common IVH or Periventricular leucomalacia? (prematurity)
IVH
110
Periventricular leucomalacia is more likely in which three cases? (prematurity)
chorioamnionitis, severe hypotension or monozygotic twins
111
What feature of periventricular leucomalacia makes it more likely to progress to cerebral palsy? (prematurity)
Cystic changes
112
what is meant by neurodevelopmental consequences of prematurity?
Even with normal USS, prem babies have an increased incidence of learning difficulties such as attention difficulties, or subtle problems in higher functioning e.g. maths which may not manifest until school
113
What is the one cardiac condition in prematurity?
PDA
114
What are 5 gastro conditions in prematurity?
NEC Osteopenia of prematurity GOR Inguinal hernias Nutrition problems
115
What is NEC
Bowel wall inflammation, ulceration and perforation, often secondary to ischaemic or hypoxic insult. Mucosal damage leads to bacterial invasion and GI gangrene and perforation.
116
Symptoms NEC
Apnoeas lethargy vomiting temp instability acidosis shock
117
Signs NEC
Shiny distended abdo Bile aspirates or bilious vomit rectal fresh blood collapse
118
What would AXR NEC show?
fixed loops of bowel, pneumatosis intestinalis, portal vein gas, pneumoperitoneum
119
What is the prognosis of NEC?
10% mortality (higher if perf) Complications of stricture and short bowel synd
120
What can help NEC?
Probiotics and breast milk
121
Why might breast milk help NEC?
Lactoferrin
122
Management NEC
Stop feeds Support circulation ABx Laparotomy if perf occurs
123
What are two risk factors for NEC
PDA and increasing milk feeds (esp formula) too rapidly
124
What is osteopenia of prematurity?
Mineral deficiency, esp phosphate. In premature infants and those of low birth weight compared to infants of the same gestation. Classically: immature infant that is solely breast fed.
125
What is the risk of inguinal hernias?
Strangulation
126
How should premature infants be fed?
NG until develop sucking reflex at 32-34 weeks May require parenteral nutrition
127
Can in-utero growth rates be achieved in premature babies?
Unlikely
128
How common is retinopathy of prematurity?
35%
129
Does retinopathy of prematurity require rx?
Most no.
130
retinopathy of prematurity prognosis
1% blind
131
Why does retinopathy of prematurity happen?
Proliferation of new blood vessels in an area of relative ischaemia in the developing retina. Can be due to oxygen toxicity (big fluctuations in supplemental o2 conc) May be genetic predisposition
132
What should happen to infants at risk of retinopathy of prematurity?
Screen by ophthalmologist
133
What happens if retinopathy of prematurity is detected?
laser ablation can prevent retinal detachment and blindness
134
Premature infnats are especially susceptible to which infections?
Group B strep and coliforms, pneumonia
135
Why do premature infants have poor thermoregulation
High SA:V ratio Immature skin poor at retaining heat and fluid Low SC fat
136
Two haem conditions prem babies can get
anaemia of prematurity neonatal jaundice
137
What should be included in a history of a premature baby
Maternal risk factors for prem Full obs hx Condition at birth-APGAR, resus? Birth weight Gestation Assoc problems e.g. twin, congenital abnorm, infection e.g. chorioamnionitis may have triggered labour Antenatal steroids given?
138
Survival rates at 24w, 27w and 32w
24w- 45% 27w- 80% 32w- excellent NB disabilities likely and more likely the smaller the gestation
139
What are 4 long term problems of prematurity?
Chronic lung disease (bronchopulmonary dysplasia) Neuro sequelae (cerebral palsy) Blindness due to RoP (getting rarer) Poor growth (esp if catch up growth not achieved)
140
Small baby is due to what 3 things?
1. prematurity 2. IUGR 3. both
141
What is VLBW?
very low birth weight \<1500g at birth, would be severely premature
142
What are different ways of calculating gestational age?
either from LMP, early dating USS or assessment of gestation after birth- Dubowitz score- physical criteria (skin development, nipple and genitalia appearance, ear form) and neuro criteria (posture, neck and limb tone, joint mobility)
143
What is a premature baby's tone and joint mobility likely to be like?
hypotonic with limbs in extension and increased joint mobility
144
IUGR defined as?
Babies SGA below 10th centile on growth chart
145
IUGR is either ___ or \_\_\_\_\_?
Symmetrical or asymmetrical
146
What is symmetrical growth restriction?
Wt, head circ and length are ALL below 10th centile in the same proportion. Could be a normal baby that happens to be small (remember 10% normal babies in this centile)
147
Symmetrical IUGR suggests the insult occurred early or late in preg?
Early
148
four causes of symmetrical IUGR?
Chromosomal abnorms Prenatal infection (TORCH) Maternal disease Maternal alcoholism
149
TORCH stands for?
Toxoplasmosis Other (syphilis) Rubella CMV (normally presents with hepatosplenomegaly, purpura (thrombocyt.), and conjugated hyperbil. Rarely causes disabling sequelae) Herpes
150
What are long term sequelae of TORCH?
Microcephaly Cerebral palsy mental retardation blindness deafness
151
What does asymmetrical growth restriction look like?
weight affected\>length\>head Infant looks long and thin, little SC fat. Skin dry, cracked, peeling days after birth
152
What is the cause of asymmetrical IUGR?
Something late in foetal development, often placental insufficiency Could also be: Toxaemia of pregnancy Multiple pregnancy Maternal smoking
153
Can asymmetrical IUGR be resolved?
Yes if adequate nutrition after birth post-natal catch up is often rapid
154
What is the main concern in IUGR?
hypoglycaemia- early and effective feeding important
155
How do you estimate expected weight had the IUGR not occurred?
Read the expected weight for whatever gestational age they are from growth chart
156
In IUGR do you feed according to expected or actual weight?
Expected
157
Small babies are prone to what five things?
Hypothermia Hypoglycaemia Feeding problems Infection Apnoea of prematurity
158
Hypoglycaemia is defined as what in a neonate?
\<2.6mmol/L
159
What is the problem with NG feeding ill premature babies?
Risk of NEC contraindicates gastric feed (because asphyxiation could impair blood flow to bowel)
160
How can you minimise risk of infection in small baby?
Avoid cross infection and use broad spec antibiotic if susp infection
161
What is apnoea of prematurity? How is it diagnosed and briefly how is it managed?
Periods of hyper and hypoventilation alternating, leading to brief apnoeic episodes. Diagnose by excluding other causes of apnoea in otherwise well premature infant. Give xanthine based drugs e.g. caffeine, theophylline.
162
Do IUGR babies have a higher risk of RDS?
No reduced due to endogenous steroid production
163
prognosis IUGR?
Very severe- can be a cause of short stature in children Severe (esp if brain growth restricted) can = intellectual impairment
164
What is talipes?
Neonatal club foot
165
Is talipes normally uni or bi lateral?
50/50
166
Cause of talipes?
Unknown, possibly genetic Can be due to being squashed in utero- corrects by 3m or some physio
167
Foot appearance in talipes?
Inverted Adduction of forefoot relative to hindfoot Equinus (plantar flexion deformity) Foot cannot be passively everted and dorsiflexed through the normal range.
168
What three things is talipes associated with
Myelomeningocele Arthrogryposis Prune belly syndrome
169
Treatment of talipes?
within a week or two of birth- ponseti method- foot manipulated and placed in long leg plaster cast on repeated occasions for about 5-8 weeks. Done gradually Normally need small op to loosen achilles after the last cast. Then wear special boots full-time first 3m, then overnight until 4/5yo If this does not work- surgery on soft tissues and/or bones from 2yo
170
Talipes prognosis
Nearly all treated with Ponseti method have pain-free, normal looking feet. Most learn to walk at normal age and can do sports when older. If unilateral may have one leg shorter than the other, smaller foot on one side. Occasionally recurs- repeat some steps of the treatment.
171
What does this picture show?
When does it normally appear?
Is it bad?
Pigmented naevus
Around 2yrs
Risk of malignancy v rare
172
What is this?
How would you describe it?
When is the onset?
What can it indicate?
Cafe au Lait spots
Uniformly pigmented, sharply demarcated macules.
Present at birth of develop during childhood
Neurofibromatosis if there are lots
173
What is this?
also known as?
Is it compressible?
What is the prognosis? Should it be treated?
Strawberry naevus/superficial haemangioma
compressible
Almost all resolve spontaneously but may get bigger first.
Don't treate unless interferes with e.g. vision
174
What is this?
AKA?
Where do they often occur?
What happens to them?
Naevus flammeus/salmon patch/stork mark
Small pink, flat lesions
Eyelids, neck, forehead
Usually fade and disappear entirely
175
What is this?
where does it often occur?
Which babies does it occur in?
What happens to it?
Mongolian blue spot
Sacral area
\>80% black and asian babies
Fades in first few years normally
176
What is this?
What is it made up of?
What if it was localised to the trigeminal area?
Port-wine stain
mature, dilated, dermal capillaries
Trigeminal= consider sturge-weber syndrome (underlying meninigeal haemangioma and intracranial calcification- assoc with fits)
177
178
If mother is colonised with group B strep, no abx prophylaxis and baby is healthy, what needs to be done to baby if anything?
Newborns with only one minor risk factor for early onset sepsis should remain in hospital for at least 24 hours with regular observations. Two or more minor risk factor or one red flag warrant empirical antibiotic therapy with Benzylpenicillin and Gentamicin and a full septic screen.
179
What are red flags for sepsis in neonate?
Suspected or confirmed infection in another baby in the case of a multiple pregnancy
Parenteral antibiotic treatment given to the woman for confirmed or suspected invasive bacterial infection (such as septicaemia) at any time during labour, or in the 24-hour periods before and after the birth [This does not refer to intrapartum antibiotic prophylaxis]
Respiratory distress starting more than 4 hours after birth
Seizures
Need for mechanical ventilation in a term baby
Signs of shock
