Neonatal Pharmacology Flashcards
(11 cards)
What is Pharmacogenetics (PGe)?
Individual gene differences in drug response
What does Pharmacogenomics (PGx) refer to?
Genome-wide approach to drug response
Which techniques are used for identifying genetic variations?
- SNPs
- haplotypes
- PCR
- restriction enzymes
Why do neonates show wide variability in drug response?
- Immature PK/PD
- Genetic polymorphisms (especially in CYP450 enzymes)
What is the status of FDA-approved drugs for neonatal use?
Few neonatal drugs are FDA-approved for neonatal use; most are off-label
What genetic variant affects caffeine metabolism in neonates?
CYP1A2: Delayed development
Which genetic variant is important for phenytoin metabolism?
CYP2C9: Very low at birth
What does CYP2C19 influence?
PPI metabolism (e.g., pantoprazole); genetically polymorphic
What transporters vary by age and genotype?
P-glycoprotein and others
Fill in the blank: Pharmacogenetics focuses on ______ differences in drug response.
[individual gene]
True or False: All neonatal drugs are FDA-approved for use.
False
