Neoplasia

Question 1

What makes lymphoma different from leukemias?

Answer 1

Lymphoma originates from solid organs while leukemia orginates from bone marrow.

Question 2

How many times more likely is a cat to get lymphoma that has FIV? FeLV and FIV?

Answer 2

FIV only = 6x

FIV and FeLV = 75x

Question 3

What dog breeds commonly get B-Cell lymphoma?

Answer 3

Cockers and bassets

Question 4

What dog breeds commonly get T-Cell lymphoma?

Answer 4

Boxers, Siberian huskies and shih tzus

Question 5

Lymphoma has a what type of age distribution? Why ini cats is this thought to be?

Answer 5

Bimodal

Young cat = FeLV

Old cat = just normal Lymphoma

Question 6

What are the four anatomic forms of lymphoma?

Answer 6

Multicentric - lymph nodes +/- spleen, liver, bone marrow

Mediastinal - Mediastinal lymph nodes +/- bone marrow

Alimentary - GI +/- intraabdominal lymphadenopathy

Extranodal - Renal, ocular, cutaneous

Question 7

What anatomic form is most common in a dog? Cat?

Answer 7

Dog - Multicentric - 80% of cases

Cat - Alimentary - 70% of cases

Question 8

Common first sign of lymphoma in dogs?

Answer 8

PU/PD - hypercalcemia. This is rare in cats

Question 9

Most common extranodal lymphomas in dogs? Cats?

Answer 9

Dogs - cutaneous and ocular

Cats - nasopharyngeal, ocular, renal, neural

Question 10

Donut shaped skin lesion consistent with?

Answer 10

Cutaneous lymphoma.

Question 11

Most cats with cutaneous lymphoma do NOT have this?

Answer 11

FeLV …weird.

Question 12

There is some reports of an association between what extranodal types of lymphoma in cats?

Answer 12

Neural and renal.

Question 13

What are the three forms of CNS lymphoma?

Answer 13

Solitary epidural lymphoma

Neuropil (intracranial or intraspinal) lymphoma— Called TRUE CNS lymphoma

Peripheral nerve lymphoma.

Question 14

Dogs with multicentric lymphoma commonly relapse into what?

Answer 14

CNS lymphoma.

Question 15

What is the only clinically relevant paraneoplastic syndrom with lymphoma?

Answer 15

Hypercalcemia in dogs.

Question 16

What paraneoplastic disease in dogs with lymphoma is rare in cats?

Answer 16

Hypercalcemia.

Question 17

What does TNM mean?

Answer 17

Tumor, node, metastasis.. staging system

Question 18

What are the stages of lymphoma (5)?

Answer 18

1. Solitary lymph node involvement
2. More than one lymph node on one side of the diaphragm
3. Generalized lymph node involvement
4. Stage 3 plus hepatomegaly or splenomegaly
5. Bone marrow or extranodal involvement
   
   1. A = Asymptomatic
   2. B = Sick

Question 19

What is the only prognostic indicator in the lymphoma staging scale in dogs?

Answer 19

Sick or not sick

Question 20

What breed of dog commonly has T-Cell lymphoma?

Answer 20

Boxers

Question 21

Hemangiosarcomas in dogs have a predilection for older dogs of what sex and breed (2)?

Answer 21

Males

German Shepherd

Goldens

Question 22

Greyhounds commonly get HSA where?

Answer 22

Hind leg musle

Question 23

What types of HSA are not aggressive?

Answer 23

Dermal and conjunctival.

Question 24

Spindle cells are a sign of what type of neoplasia?

Answer 24

Sarcoma.

Question 25

What is the probability of diagnosing HSA on cytology from effusion?

Answer 25

\<25%

Question 26

What is the big difference between cats and dogs with primary bone tumors?

Answer 26

Cats can be cured with wide surgical excision.

Question 27

Canine OSA causes what in racing greyhounds vs show greyhounds?

Answer 27

Racing greyhounds: 25% of death Show greyhounds: OSA is extremely rare.

Question 28

Unique places for osteosarcoma in Great danes, Rotties and Greyhounds?

Answer 28

Great danes - distal radius Rotties and Grey hounds - proximal femur

Question 29

What is a negative prognostic indicator with OSA?

Answer 29

Lung mets

Question 30

What breed is at high risk for MCT?

Answer 30

Brachiocephalic Goldens

Question 31

10-15% of MCT are indistinguishable from?

Answer 31

lipomas

Question 32

What are the three categories of MCT?

Answer 32

Well differentiated - 1 Moderately differentiated - 2 Differentiated - 3

Question 33

What type of metastasis is common with MCT?

Answer 33

Skip metastasis - every lymph node in the region should be aspirated.

Question 34

What percentage of dogs with advanced MCT have gastroduodenal ulceration?

Answer 34

80%

Question 35

What type of MCTs are seen in cats?

Answer 35

Visceral and cutaneous.

Question 36

Multiple intestinal masses in cats are most commonly associated with?

Answer 36

Lymphoma and MCT (can coexist)

Question 37

What is the biologic behavior of cutaneous mast cell in cats?

Answer 37

Benign

Question 38

What type of tumor is injection site sarcomas normally?

Answer 38

Fibrosarcoma

Question 39

What is the 3,2,1 rule for injection site tumor in cats?

Answer 39

3. mass persists for more than 3 months 2. mass is larger than 2cm 1. mass grows 1 month after injection

Question 40

How do injection site sarcomas (FSA) differ from regular FSA?

Answer 40

Injection site sarcomas (FSA) are much more aggressive.