Neoplasms Flashcards
(14 cards)
Telemerase
protect the ends of chromosomes and shortens w each cell division
nucleus
contains DNA which controls cells, enclosed by nuclear membrane
cytoplasm
contains all nutrients, proteins, and glucose.
Mutation
If DNA is altered in the parent cell, the mutation is passed onto the daughter cells.
What cells have rapid mitosis
epithelial cells, leukocytes
what cells do not go through mitosis
neurons, cardiac muscle
Benign suffix
OMA.
Malignant epithelial suffix
carcinoma
malignant connective
sarcoma
Benign tumour
Undifferentiated cells that usually reproduce at a higher than normal rate. Encapsulated, expands but does not spread.
Malignant tumors
Undifferentiated, nonfunctional cells that do not appear organized. Reproduce rapidly. Infiltrate and spread to surrounding tissue.
Pathophysiology of tumor
Normal organization, growth inhibition, contact controls, and cell–cell communication are absent. Cell membranes, including surface antigens, are altered. The expanding mass compresses nearby blood vessels, leading to necrosis and an area of inflammation around the tumor
Chemo drugs
Adriamycin (doxorubicin), an antitumor antibiotic that binds DNA and inhibits synthesis of nucleic acids, acting primarily on cells in the S phase (DNA synthesis) but with some activity in other stages (e.g., altering the cell
membrane)
* Bleomycin, also an antitumor antibiotic that inhibits DNA synthesis
* Vinblastine, a cell-cycle–specific antimitotic drug that acts on cells in the M stage
(mitosis)
* Dacarbazine, an alkylating agent nonspecific drug acting at several points in the
cycle