Neoplastic Skin Changes- Schaper Flashcards Preview

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Flashcards in Neoplastic Skin Changes- Schaper Deck (20):

Flat or slightly elevated, smooth, sharply circumscribed, uniform brown/black/tan

What is the most likely diagnosis?

Junction Nevi


Slightly elevated, dome-shaped, papule;

smooth or papillomatous surface; fleshy or brown

What is the most likely diagnosis?

Compound Nevi

The nevus cells are at the dermo-epidermal junction and upper dermis


Dome shaped, verrucoid (warty) pedunculated or sessile

brown, black, pink

What is the most likely diagnosis?

Dermal Nevi

nevus cells at dermis, sometimes among fat cells


where are the nevus cells located for a blue nevi and Nevus spilus?

Dermal layer


Characteristics of benign nevi


well defined border

uniform color

<6 mm


reddish pink, dome shaped, smooth papule 

usually on the face, scalp, or legs

Pre- adolescentWhat is the most likely diagnosis?



a spitz nevus can be a compound or dermal nevus

the vast majority of atypical spitz tumors are cured with local excision  


a 55 yo presents w

Red, Vascular papual on the trunk

normally 2-5 mm

What is the most likely diagnosis?


noncancerous overgrowth of blood vessels in the skin

no known cause and no treatment needed




a pregnant female presents with

red, vascular papule that bleeds easily


What is the most likely diagnosis?

what is the treatment

Pyogenic granuloma

usually occurs on the head, neck, upper trunk and fingers

Treatment: curettage and cauterization, cryotherapy



a child comes in with a red papule with a yellow-white hue on his face

What is the most likely diagnosis?

juvenile xanthogranuloma

usually disappears on its own and requires no treatment


Buzzwords for Melanoma

S-100 tumor marker

sun exposure

Breslow depth (associated with risk of metastasis)

mutation in BRAF kinase

treat with vemurafenib or excision with 2 mm margins


a 65 yo female presents with

a >6mm flat, asymmetric mass with varying colors

What is the most likely diagnosis?

Superficial Spreading Melanoma

the lesion can spread laterally for years prior to developing nodules


a pt comes in with a rapidly growing lesion on the right forearm.  

The lesion is raised, brown, and appeared suddenly.

What is the most likely diagnosis?

Nodular melanoma

equally common in females and males

can be found in any location but more often on the extremities

lesions are raised

may bleed 

evolove over moths and tend to extend vertically into skin


a pt presents with:

a flat, irregularly outlined, mottled, brown lesion on the cheack

a wood's light reveals irregular pigmentation around the lesion.

What is the most likely diagnosis?

Lentigo Maligna Melanoma


a 67 yo male comes in with a strip down the center of his big toe.

What is the most likely diagnosis?

Acral Melanoma

more common in older patients (don't think kids on this one)

usually located on the hands and feet including the nails of darker skinned people

Hutchinson's sign is a black or brown pigment from the nailbed 



Basal Cell Carcinoma

Most common form of skin cancer


local invasive

pink, pearly nodules with rolled borders

Palisading nuclei


a 30 yo comes in with multiple lesions that are oval, red, and scaling.  

What is the most likely diagnosis?

Superficial BCC

Thinnest and least aggressive

multiple lesions, appears earlier in life

the tumor spreads peripherally, sometimes for several centimeters

round to oval, red, scaling plaques



pt has been diagnosed with BCC on the face.

How do we treat it?

Moh's micrographic surgeryremove skin cancer one layer at at time and examine them under a microscope immediately


pt presents with yellowish scale that can be felt.  He said the lesion originally presented as redness with some spider-web looking red bv.

What is the most likely diagnosis?

How do we treat it?

Actinic keratosis

common keratotic lesion with malignant potential → SCC

Cryotherapy, topical 5 FU, topical Imiquod, photodynamic theraapy



Squamous cell Carinoma

sunlight, immunosuppression, arsenic exposure

lower lip, ears, hands

locally invasive and may spread to lymph nodes

ulcerative red lesions with frequent scale

chronic draining

kerating pearls

Actinic Keratosis


A pt presents with 

purple patches on the distal lwer extremitiy that have progressed proximally

the individual lesions darken and thicken before becoming brown and verrucous

What is the most likely diagnosis?

Kaposi's Sarcoma

a malignancy of lymphatic endothelial cells associated with a gamma herpes virus, HHV8


The most common AIDS-associated cancer