nephritic syndrome Flashcards
(12 cards)
what is rapidly progressive glomerulonephritis
rapid loss of renal function associated with the formation of epithelial crescents in majority of glomeruli
causes of rapidly progressive glomerulonephritis
goodpasture’s syndrome
granulomatosis with polyangiitis
SLE, microscopic polyarteritis
features of rapidly progressive glomerulonephritis
nephritic: haematuria with red cell casts, proteinuria, hypertension, oliguria
features to specific underlying cause
classic presentation of IgA nephropathy
macroscopic haematuria in young people 1-2 days after URTI
associated conditions with IgA nephropathy
alcoholic cirrhosis
coeliac disease/dermatitis herpetiformis
HSP
pathophysiology of IgA nephropathy
mesangial depositions of IgA immune complexes
difference between post-strep and IgA nephropathy
post-strep is associated with low complement levels, and proteinuria
IgA is associated with haematuria
post-strep occurs 1-2 weeks post URTI
general management of nephritic syndromes
generally supportive
- control BP
- treat any fluid overload
treat specific underlying cause
treatment of proteinuria
ACEi or ARBS
what is alport’s syndrome
X-linked dominant inherited condition causing defect in type IV collagen resulting in abnormal glomerular-basement membrane
presentation of alport’s syndrome
usually presents in childhood
persistent haematuria
progressive renal failure
bilateral sensorineural deafness
lenticonus: eye problems
retinitis pigmentosa
renal biopsy results in alports
splitting of lamina densa
