NERVOUS SYSTEM

Question 1

Cerebrospinal Fluid not present in?

Answer 1

corpus collasum

Question 2

CSF fills ?

Answer 2

ventricles and the subarachnoid space.

Question 3

Bacterial Meningitis the CSF glucose levels?

Answer 3

glucose Decrease but WBC increase.

Question 4

Intrathecal medications are administered in ?

Answer 4

CSF.

Question 5

CSF produced by?

Answer 5

ependymal cells

Question 6

CSF produced in?

Answer 6

choroid plexuses

Question 7

Which choroid plexuses produces?

Answer 7

ventricles of the brain

Question 8

BBB is formed by?

Answer 8

capillary ENDOthelial cells

Question 9

WHICH TYPE OF drugs cross faster through BBB?

Answer 9

Lipids soluble drugs

Question 10

Drugs that cross BBB

Answer 10

Rifampin, Cefuroxime sodium, Cefotaxime, Carbapenem, Atropine, Physostigmine, diphenhydramine, levodopa, and ethanol.

Question 11

Blood brain barrier is present at?

Answer 11

Capillary endothelial cells.

Question 12

Major Peripheral nerve in Cervical plexus

Answer 12

Phrenic nerve —lungs

Question 13

4 Major Peripheral nerve in Brachial plexus

Answer 13

radiaL
ulnar nerve—adduction and abduction of fingers.
Auxillary
median

Question 14

radial nerve present in?

Answer 14

Forearm, Wrist to thumb

Question 15

ulnar nerve present in?

Answer 15

Shoulder, Elbow–wrist, Ring and small finger,

Question 16

Which nerve is present in tere minor muscle?

Answer 16

Auxillary nerve (circumflex)

Question 17

Which nerve is present in deltoid muscle?

Answer 17

Auxillary nerve (circumflex)

Question 18

Which nerve is present in shoulder joint?

Answer 18

Auxillary nerve (circumflex)

Question 19

Which nerve is present in skin on back of the arm?

Answer 19

Auxillary nerve (circumflex)

Question 20

Which nerve supplies to muscles of forearm?

Answer 20

Radial nerve

Question 21

Radial nerve damage cause?

Answer 21

Elbow/wrist drop

Question 22

Ulnar nerve damage cause?

Answer 22

Claw hand

Question 23

Loss of sensation over the lower half of the deltoid?

Answer 23

Axillary nerve damage

Question 24

Median nerve present in?

Answer 24

Thumb and index fingers.

Question 25

Which nerve is supplied to lungs

Answer 25

Phrenic nerve

Question 26

Major Peripheral nerve in Sacral Plexus

Answer 26

Sciatic nerve

Question 27

Sciatic nerve passes to?

Answer 27

Runs through buttock, thighs down to foot

Question 28

Which nerve is supplies to pelvic girdle and lower limbs?

Answer 28

Obturator, femoral, saphenous nerve--LUMBAR PLEXUS

Question 29

Which cranial nerve is responsible for chewing motions?

Answer 29

Trigeminal nerve

Question 30

Vagus nerve is?

Answer 30

parasympathetic nerve

Question 31

Multiple Sclerosis treatment

Answer 31

- -->Interferons beta (first line therapy), - -->glatiramer acetate (Immunomodulators similar to interferon beta), - -->mitoxantrone, - -->natalizumab, - -->Fingolimod (spingosine-1-phosphate receptor agonist), teriflunomide - -->laqinimod.

Question 32

Vertigo treatment

Answer 32

Antihistamine: diphenhydramine, scopolamine Benzodiazepines; Calcium ion channel blockers: flunarizine

Question 33

Meniere’s Disease

Answer 33

vertigo along with tinnitus, dizziness, nausea and progressive deafness

Question 34

Drug causing Malignant Hyperthermia

Answer 34

drugs that cause fever symptoms. E.g. Halothane, isoflurane and succinylcholine

Question 35

Tx of Malignant Hyperthermia

Answer 35

Dantrolene 2.5 mg/kg for Q5min

Question 36

Drug causing Neuroleptic Malignant Syndrome

Answer 36

antipsychotic drugs

Question 37

Tx of Neuroleptic Malignant Syndrome

Answer 37

Bromocriptine 2.5-20 mg TID

Question 38

Tx of Meniere’s Disease

Answer 38

Beta-histine

Question 39

>37.8 °C/100.04 °F

Answer 39

Fever

Question 40

High fever

Answer 40

>40.5 °C (104.9°F)

Question 41

<32 °C it can cause

Answer 41

ventricular arrhythmias

Question 42

Febrile seizure

Answer 42

41–42°C.

Question 43

Tx of Febrile seizure

Answer 43

Recommend Cool bath and Acetaminophen.

Question 44

What part of brain controls voluntary and involuntary movements

Answer 44

Cerebrum

Question 45

Single innervation Target organs (sympathetic nervous system only

Answer 45

``` Sweat glands Peripheral blood vessels Hair follicles Brown adipose tissue Adrenal medulla Kidney Tongue ```

Question 46

Dyskinesia is associated with?

Answer 46

Cerebrum

Question 47

largest of cranial nerve.

Answer 47

Trigeminal nerve

Question 48

WHich ring is present in serotonin

Answer 48

Indole ring (6 Carbon ring+5carbon ring with a NITROGEN)

Question 49

Precursor of Serotonin

Answer 49

Tryptophan

Question 50

Drug acting on NMDA

Answer 50

Memantine

Question 51

DRugs acting on GABA

Answer 51

Barbiturate, Benzodiazipine, Antiepileptic, Alcohol

Question 52

Dopamine is present in which pathwayS

Answer 52

Mesolimbic pathway | Mesocortical pathway

Question 53

Beta 2 agoinist basic structure?

Answer 53

Beta phenyl (ring) amino (NH2) substituent

Question 54

Ring in alpha 2 AGONIST ( clonidinine brimodinine

Answer 54

Imidazoline ring

Question 55

Propranolol is known for its .......?

Answer 55

Lipid solubility ( reason for CNS barrier crossing)

Question 56

All alpha blockers cause

Answer 56

First dose effect ( syncope/Orthostatic hypotension) :LOwer the first dose

Question 57

ALpha blocker used for scorpion sting

Answer 57

Prazosin

Question 58

Alpha Agonist ends in.......1. | Alpha blockers ends in .....2..

Answer 58

1. dine -agonist ( | 2. zine-antagonist ( First dose effect)

Question 59

Cardioselective B blocker

Answer 59

EMAABB (Esmolol, Metoprolol, Acebutalol, Atenolol, Besoprolol, betoxalol)

Question 60

WHich structure is essentilal for adrenergic activity?

Answer 60

Ethylamine chain

Question 61

Chemistry of Anticholinergic drugs: quaternary amines use

Answer 61

COPD medications: cannot cross BBB

Question 62

Chemistry of Anticholinergic drugs: Tertiary amines use

Answer 62

Urinary incontinence, Parkinson's disease,Motion sickness

Question 63

MUscarinic blocker structure

Answer 63

Piperidine + pyrolidine = QUASI RING

Question 64

Sure: 4 questions from these 4 section

Answer 64

AnTIHISTAMINE Serotonin Prostaglandin NSAID

Question 65

HIstamine chemically produced from which amino acid?

Answer 65

decarboxylation of histidine

Question 66

Opiod iV must be given carefully

Answer 66

They stimulate histamne and profound vasodilation and hypotension

Question 67

Structure of diphenhydramine

Answer 67

Have tertiary amine- cross BBB- sedation

Question 68

Trazadone contains which ring

Answer 68

m-phenyl piperidine

Question 69

In all 5HT3, which ring is present

Answer 69

Indole ring, drugs are ondasetrone, palonosetrone, granisetrone

Question 70

Cisaperide is withdrawn from the market, what is now available

Answer 70

Tagaseride

Question 71

WHat are Ecosanoides

Answer 71

are long chain fatty acids Derived from arach donic acid